查询词典 lethal dose

Serum containing SSTG was obtained at different time after perorally administrated with different dose of SSTG.The cardiomyocytes were deprived of oxygen and glucose to mimic hypoxia reoxygenation injury and were treated by serum containing SSTG when reoxygenation.LDH content in supernatant was detected after reoxygenation.LDH release suppression rate was used to study the time-effect and dose-effect of serum containing SSTG.

以中药有效组分配伍方剂双参通冠方不同灌胃剂量、药后不同取血时间所得的药物血清为受试药物；培养心肌细胞，进行缺氧复氧实验，复氧同时给予不同双参通冠方药物血清处理，实验结束后取培养上清检测LDH值，以LDH释放抑制率为指标，观察含药血清药理作用强度与体内给药的量效、时效关系。

Results showed that the seed germination rate,emerged seedling rate and survival seedling rate of Platanus aceriflia Willd.decreased with dose increase at the dose of 50～400Gy,as well as the plant height,fresh weight and length of root.

结果表明，在50~400Gy辐射范围内，随着剂量的增加，悬铃木种子的萌发率、出苗率、成苗率降低，株高、鲜重、根长也明显下降。

Patients with dental impaction received a presurgical dose 30 minutes before surgery and a postsurgical dose 3 hours later.

有牙科阻生的病人有手术前30分钟接受了一个手术前剂量，而在3小时后接受了一次手术后剂量。

Results:① large dose of piracetam(≧600mg/kg) significantly increased scores of praxiology(p.01)、decreased water content(p.05) and the expression of aquaporin( aqp4) in mcao.②all dose of piracetam decreased volume of ischemic (p.01) and remained relatively intact ultramicrostructure.

结果：吡拉西坦注射液剂量依赖性地降低侧大脑半球的含水量、改善其神经功能评分、下调水通道蛋白4(aop4)的表达、降低动物的脑梗死体积、改善缺血脑组织神经元细胞的超微结构。

In the preapproval clinical experience with a new medicinal product or its new usages, particularly as the therapeutic dose may not be established, all noxious and unintended responses to a medicinal product related to any dose should be considered adverse drug reactions.

指对于仍处于上市前临床研究的新医药产品或其新用法，尤其在其治疗剂量尚未建立以前，所有与药物任何剂量有关的有害或不期望的反应，均应认作为药品不良反应。

Methods The patients who had symptoms were treated with large-dose zinc sulfate (100-150mg,＜6yr;150-200mg,6-8yr;200-300mg,9-10yr;300mg,＞10yr; 3 times a day) in addition to low-dose penicillamine(8-10mg/kg/d) at the beginning of treatment. Zinc sulfate alone was given to the presymptomatic patients and it was used as maintenance therapy when clinical improvement was obtained.

有症状患儿初期用小剂量青霉胺(每天8～10mg/kg)，加大剂量硫酸锌(＜6岁100～150mg ，6～8岁150～200mg ，9～10岁200～300mg ，＞10岁300mg ，每天3次)联合治疗；病情好转后和症状前期患儿单用硫酸锌维持治疗。

RESULTS: HE stained cells were fusiform-shaped with pseudopodia, round or oval nucleus. The cytoplasm was blue after stained with the toluidine blue. The immunohistochemical test revealed that there existed positive expression of type Ⅰ collagen in the cells. In the presence of 10% calf serum, IGF-Ⅰ significantly improved cell proliferative activity in a dose-dependent manner within effective dose range.

结果：苏木精－伊红染色细胞多为梭形，有伪足伸出，细胞核为圆形或椭圆形；甲苯胺蓝染色，胞浆为深蓝色；免疫细胞学方法检测表明纤维环细胞有Ⅰ型胶原表达；在体积分数为0.1的血清条件下，胰岛素样生长因子Ⅰ能提高细胞的增殖活性，并且在有效浓度范围内呈剂量效应关系。

Results:①The amount of human colon carcinoma cell line SW480 treated by quercetin decreased. The morphology of partial SW480 cells was shrunk volume, integrated cell membrane, condensed cytoplasm, pyknotic chromatin, nuclear fragmentation. Apoptotic Corpuscles were found by electron microscope.②MTT colorimetric assay showed quercetin inhibited the growth of human colon carcinoma cell line SW480 in a time- and dose-dependent manner when the concentration of quercetin was 30、60、90μmol/L.③Flow cytometry analysis showed the cell cycle of SW480 cell was restricted in G1/S. G0/G1 phase rate increased and S phase rate decreased with increasing concentration of quercetin and time lasting.④ Zymogram analysis assay showed the secretion of matrix metalloproteinases in human colon carcinoma cell line SW480 treated by quercetin decreased. With increasing concentration of quercetin, the secretion of MMP-2 and MMP-9 decreased.⑤Immunohistochemistry method demonstrated the position expression of Cathepsin-D in SW480 cell was suppressed by quercetin in a time- and dose-dependent manner.

研究结果：经槲皮素处理的人结肠癌SW480细胞数量减少，部分细胞体积缩小，细胞膜完整，胞浆浓缩，核染色质固缩，细胞核碎裂，形成凋亡小体；MTT法检测显示当作用浓度为30μmol/L~90μmol/L时，槲皮素对人结肠癌SW480细胞的生长有抑制作用，其抑制作用随着作用浓度的增加和作用时间的延长而增强；流式细胞学发现槲皮素主要作用于人结肠癌SW480细胞周期的G1/S期，大部分细胞被阻断于S期，随药物浓度的升高和作用时间的延长，G0/G1期细胞比例逐渐增加，S期细胞比例逐渐减少；酶谱分析法检测显示不同浓度的槲皮素能够抑制人结肠癌SW480细胞分泌MMP-2及MMP-9，随浓度的升高，MMP-2及MMP-9的分泌量减少；免疫组织化学法显示不同浓度的槲皮素处理人结肠癌SW480细胞后，Cathepsin-D的表达随药物浓度的升高和作用时间的延长而降低。

The concentration of enantiomers was positively related to the maintenance dose of warfarin, but not to drug response. It is not applicable to adjustment of the dose by monitoring the concentration of racemic warfarin, or to its enantiomers.

异构物浓度与维持剂量间有显著的相关性存在，但与疗效间却没有直接的相关，故无法以监测浓度的方式来调整病患之剂量，仍需采用临床上使用的INR值来监测。

Rats in control group and model group received 0.9% sodium chloride solution 10 mL/kg. Rats in compound danshen dripping pills group received 0.75% compound danshen dripping pills 10 mL/kg. Rats in Xintongzhi drop pill high dose group and Xintongzhi drop pill low dose group received 3.6%, 1.8% Xintongzhi drop pill 10 mL/kg, respectively. After 7 days except control group, myocardial ischemia models were established by ranine vein of hypophysin in other four groups. The changes of lactate dehydrogenase,α-Hydroxybutyrate Dehydrogenase, creatine kinase, creatine kinase MB and ECG were recorded in each groups.

正常组和模型组予0.9%氯化钠注射液，复方丹参滴丸对照组予0.75%复方丹参滴丸水溶液，心痛治滴丸高剂量组、心痛治滴丸低剂量组分别给予3.6%、1.8%的心痛治滴丸水溶液，各组均10 mL/kg，每日1次灌胃。7日后除正常组外，其余4组均采用垂体后叶素0.5 U/kg舌下静脉注射制备大鼠急性心肌缺血模型，并检测各组乳酸脱氢酶、α-羟丁酸酶、磷酸肌酸激酶及磷酸肌酸激酶同工酶和心电图的改变。

Foods high in this vitamin include oily fish such as salmon, tuna and, and fish liver oils.

维生素D含量高的食物包括诸如大麻哈鱼、金枪鱼和鲭鱼之类的油鱼以及鱼肝油。

We need you to cosign our public letter demanding that press intimidation cease immediately, and that all charges be dropped.

我们需要您cosign我们的公共信，要求记者立即停止恐吓，并要求所有收费下降。