查询词典 lethal dose

On the other hand, the intensity of ultrasound stated, percutem transit dose of drug could be increased along with the time at the range of 10 min to 30 min. However, if it was given ultrasound over 40min, percutem transit dose of drug would be reduced significantly. Therefore, it was supposed that skin temperature was increased during a long time of ultrasound, and the skin would be damnified.

超声强度一定时，超声时间由10分钟加长到30分钟时，药物的累积经皮渗透量增加，当超声时间增加到40分钟时，药物的经皮渗透量却明显减小，可能是由于超声时间加长后，使皮肤温度显著升高，对皮肤造成损伤所导致的结果。

Internal dose ones and external dose ones are concluded.(2) Biomarker of effect. It indicates those indicaters inflecting the biochemical, biophysical, behavioral, or else changes. Three types of biomarkers, early biological effect, altered structure / functon and disease, are comprised.

生物标志物是包括反映生物系统与环境中化学、物理或生物因素之间相互作用的任何测定指标，可将其分为三类：(1)接触的生物标志物，即反映机体生物材料中外源性物质或其代谢物或外源性物质与某些靶细胞或靶分子相互作用产物的含量，包括反映内剂量和生物效应剂量两类标志物；(2)效应的生物标志物，指机体中可测出的生化、生理、行为或其他改变的指标，包括反映早期生物效应、结构和功能改变(altered structure/functon)及疾病3类标志物；(3)易感性的生物标志物，即反映机体先天具有或后天获得的对接触外源性物质产生反应能力的指标。

Methods: A total of 21 young swines were randomly divided into untreated group, low-dose salvianolate group and high-dose salvianolate group (7 in each group). AMI was induced by ligaturing left anterior descending coronary artery. After the operation, 400 or 200 mg salvianolate dissolved in 250 mL 5% glucose saline was administered by intravenous drip to swines in the HS group and the LS group respectively for 7 days. The swines in the untreated group were administered with 250 mL 5% glucose saline.

苏中幼猪21只，随机分为模型组和低、高剂量丹参多酚酸盐组。3组均经开胸结扎冠状动脉左前降支制作心肌梗死模型，造模成功后当日，高剂量丹参多酚酸盐组给予400mg丹参多酚酸盐加250mL 5%写葡萄糖生理盐水静脉滴注；低剂量丹参多酚酸盐组给予200mg丹参多酚酸盐加250mL 5%葡萄糖生理盐水静脉滴注；模型组给予等体积的5%葡萄糖生理盐水静脉滴注。1次／d，连续给药7d。

Through reforming original dose calculation models established for regular irradiation field, we present a set of more efficient and systematical solution to calculate dose distribution of regular irradiation field.

我们在对原有规则野剂量计算模型和算法中存在的各种缺陷进行改进和有机合成的基础上，提出了一整套规则野剂量计算的更优解决方案。

Our results indicated that (1)SO_2 derivatives could dose-dependently relax the isolated aorta rings with or without endothelium precontracted by NE, no difference was found for the rings with and without endothelium;(2)Levels of cAMP and 6-Keto(PGI_2) in isolated aortic rings were increased by SO_2 derivatives in a dose-dependent way, which were independent of endothelium;(3)SO_2 derivatives decreased cGMP levels in the rings, but not significantly; The decrease of cGMP levels was also independent of endothelium;(4)No changes of TXB_2 in rings with or without endothelium were observed;(5)Whether presence or absence of endothelium, cAMP/cGMP and 6-Keto/TXB_2 ratios were increased significantly.

结果：①SO_2衍生物对去甲肾上腺素预收缩的内皮完整和去除内皮的大鼠胸主动脉血管环均呈浓度依赖性舒张作用，且其张力变化在内皮完整与去内皮的血管环之间无显著性差异；②SO_2衍生物可引起血管组织中cAMP、6-Keto(即PGI_2)含量剂量依赖性增加，其增加程度与内皮无关；③SO_2衍生物对血管环cGMP含量呈降低趋势但在统计学上无显著意义，且对去除内皮血管无显著影响；④SO_2衍生物对去内皮或内皮完整血管环的TXB_2含量均无明显影响；⑤无论是否去除内皮，SO_2衍生物均可引起cAMP／cGMP和6-Keto／TXB_2比值显著升高。

Dose-response indicated that the adults were more attracted when the dose of mango pulps was increased.

剂量反应结果表明，随着测试剂量的增加，芒果果肉挥发物对桔小实蝇成虫的引诱作用增强。

It seems to be a safe and effective combination. After one month the low-dose aspirin can be reinstituted and after one week the standard dose clopidogrel (75 mg) can be used.

这看似一种安全有效的联合。1个月后则重新应用小剂量阿司匹林，以及1周后应用标准剂量的氯吡格雷（75 mg/d）。

Should this modest increase in dose not be sufficient to alleviate symptoms, we double the prednisone dose. The disease flare is allowed to subside and the taper is reinstituted at a slower rate or at smaller decrements (eg, one-half of the original decrement). There are, to our knowledge, no data supporting one method or another.

如果这种剂量适度增加不足以缓解症状，我们则把强的松剂量加倍，当疾病复发平息后，再重新开始缓慢减量（如每月1次）或减量少一些（如原来减少量的1/2），据我们的了解，尚无支持一种或另一种方法的资料。

The different doses of 7603 and8102(100,400 and 1000mg/kg,which are eqivalent to 10,40 and 100times of the prescribed human dose)were given to ICR mice on the 7—11days of gestation.In the number of resorbed fetuses,the number of livefetuses,fetal weight and congenital malformations there were no signifi-cant difference between the control mice and the mice recieved variousdoses of 7603,or 8102,except the dose of...

结果可见，从7603各剂量组和8102的100、400毫克/公斤剂量组未观察到药物对孕鼠体重增长、活胎率、吸收胎率、胎鼠体重和胎鼠畸形发生率的影响。8102 1000毫克/公斤组则由于药物的毒副作用产生活胎率下降，吸收胎率和骨骼畸形率增加，孕鼠体重增长缓慢。

Kg-1, excitation dose was 2 times of sensitizing dose. The reaction of each animal was observed after excitation.

kg-1，静脉注射激发量是致敏量的2倍，激发后详细观察记录每只动物的反应情况。

There are different types of personal loans available.

有许多不同类型的个人贷款优惠。

The above mentioned teaching model of spiral rising can be used to avoid rigidness in teaching.

上述螺旋式上升的教学模式，可以避免教学形成模式後的僵化现象。