查询词典 lethal dose

At the depigmentation assay, DH and EH show dose-dependently inhibitory activities against mushroom tyrosinase, and the IC50 is 5.697 and 5.256 mM, respectively, and show noncompetitively inhibitory modes in the present of tyrosine, but not DOPA. The control synthetic products, D and E, have no inhibitory effects on tyrosinase. Using tyrosinase activity staining in PAGE gels, both DH and EH show dose-dependently inhibitory pattern in the presence of tyrosine, while, EH also could suppress tyrosinase activity in the presence of DOPA.

而美白活性方面，以商品酪胺酸以商品酪胺酸酵素进行实验，当基质为酪胺酸时，发现DH与EH具浓度相关抑制效果，IC50分别为5.697与5.256 mM，且其相对於基质酪胺酸之抑制型态皆为非竞争型抑制，而其结构类似物之对照化合物D与E则不具此活性；但当基质为多巴时则皆不具此活性；利用原态PAGE电泳活性染色亦发现抑制酪胺酸酵素结果，但EH在基质为多巴时也能下降酪胺酸酵素活性。

The treatment was performed using 4 to 6 arcs delivering with noncoplanar isocenter beams. 13 patients treated with one target,47 patients treated with multi-targets.60 patients who were treaded with SRT received a mean dose of 54.7±6Gy with a 4～8Gy/f,3f/w,qod regimen,the dose were divided 6～12times.

单靶点X-SRT治疗13例，多靶点X-SRT治疗47例，每次分割剂量4～8Gy，照射6～12次，每周3次，隔日1次，1 中心参考剂量线定在90%，2个中心参考剂量线定在50%～80％，肿瘤剂量42～48Gy。

About 48%(90/194) were below 29 years of age. Ninety-nine of 194 cases had either radiotherapy alone or supplementary treatment with radiotherapy following surgery. We analyzed multiple prognostic factors. The factors of importance included postoperative radiotherapy; female in glioblastoma multiforme; the primary tumor dose above 5000 rads and/or whole brain irradiation in malignant astrocytoma and glioblastoma multiforme; the primary tumor dose above 4500 rads in ependymoma, medulloblastoma and oligodendroglioma; and spinal axis irradiation above 2000 rads in ependymoma and medulloblastoma that produced a better prognosis than in other groups.

男与女之比例为2.7比1，年龄分布自1至81岁，平均年龄33.3±19.3岁，中值年龄为34岁，29岁以下占48%(90/194)，其中99例单独或手术后辅以放射腺治疗，分析同种脑瘤的预后因素，其中多形神经胶母细胞瘤有手术后放射线治疗或女性，多形神经胶母细胞瘤合并星细胞瘤原发肿瘤剂量5000雷得以上或曾全颅腔照射，神经管胚细胞瘤，间胶质母细胞瘤，及室管膜瘤原发肿瘤剂量4500雷得以上，室管膜瘤及神经管胚细胞瘤有脊轴照射2000雷得以上预后均佳，且统计上有显著的差异。

The effect of genistein (0.8 mg/kg) was partially inhibited by L-NAME, or by sodium orthovanadate (50 μg/kg), a potent inhibitor of protein tyrosine phosphatase;(2) genistein also decreased the PP of renal vascular bed in a dose-dependent manner and the effect of genistein was completely inhibited by pretreatment with sodium orthovanadate, but unaffected by L-NAME; and (3) genistein decreased the PP of mesenteric vascular bed in a dose-dependent manner, an effect which was partially inhibited by sodium orthovanadate, but unaffected by L-NAME.

GST的这一效应可被L-硝基精氨酸甲酯部分阻断，预先注射蛋白酪氨酸磷酸酶抑制剂正钒酸钠(50 μg/kg)，可部分抑制GST (0.8 mg/kg)引起的效应；(2)向肾血管灌注环路中直接注射 GST 也可剂量依赖性地降低肾动脉的灌流压，预先注射正钒酸钠可完全抑制GST引起的效应，而L-NAME对此效应没有影响；(3)肠系膜血管灌流环路中注射GST可剂量依赖性地降低其灌流压，这一效应可被正钒酸钠部分抑制，而L-NAME对此无影响。

Mg/ kg way partially inhibited by L- NAME,or by sodium orthovanadate(50 ug/ kg),a potent inhibitor of protein tyrosine phosphatase;(2)genistein also decreased the PP of renal vascular bed in a dose-dependent manner and the effect of genistein was completely inhibiteby pretreatment with sodium orthovanadate,but unaffected by L- NAME;and(3 genistein decreased the PP of mesenteric vascula bed in a dose-dependent manner,an effect which was partially inhibited by sodium orthovanadate,but unaffected by L- NAME .

mg/ kg引起的效应；(2)向肾血管灌注环路中直接注射GST也可剂量依赖性地降低肾动脉的灌流压，预先注射正钒酸钠可完全抑制GST引起的效应，而L- NAME对此效应没有影响；(3)肠系膜血管灌流环路中注射GST可剂量依赖性地降低其灌流压，这一效应可被正钒酸钠部分抑制，而L- NAME对此无影响。

The effect of genistein (0.8 mg/kg) was partially inhibited by L-NAME, or by sodium orthovanadate (50 μg/kg), a potent inhibitor of protein tyrosine phosphatase;(2) Genistein also decreased the PP of renal vascular bed in a dose-dependent manner. The effect of genistein was completely inhibited by pretreatment with sodium orthovanadate, but unaffected by L-NAME;(3) Genistein decreased the PP of mesenteric vascular bed in a dose-dependent manner, an effect which was partially inhibited by sodium orthovanadate, but unaffected by L-NAME.

GST的这一效应可被L-硝基精氨酸甲酯部分阻断，预先注射蛋白酪氨酸磷酸酶抑制剂正钒酸钠(50 μg/kg)，可部分抑制GST (0.8 mg/kg)引起的效应；(2)向肾血管灌注环路中直接注射 GST 也可剂量依赖性地降低肾动脉的灌流压，预先注射正钒酸钠可完全抑制GST引起的效应，而L-NAME对此效应没有影响；(3)肠系膜血管灌流环路中注射GST可剂量依赖性地降低其灌流压，这一效应可被正钒酸钠部分抑制，而L-NAME对此无影响。

Methods Forty rats were randomized into normal control group and FS group. The normal control group was fed with conventional forage. FS group was fed with dry forage mixed with FS powder for 3 months, the preliminary dose of FS was 200 mgkg^(-1)d^(-1) and then increased progressively by l00 mgkg^(-1)d^(-1) to ensure over half of the rats having diarrhea, and the final dose was 2800 mgkg^(-1)d^(-1). The frequency and amplitude of colic slow wave were detected and the changes of myenteric plexus and ICC were observed by zinc iodide -osmic acid staining method.

方法］SD大鼠40只，随机分为2组：正常对照组、番泻叶组（饲以含番泻叶粉的乾饲料，起始剂量为200 mgkg^(-1)d^(-1)，以100 mgkg^(-1)d^(-1)剂量递增，保持对半数以上动物有泻下作用，连续3个月，终剂量为2800 mgkg^(-1)d^(-1)，检测大鼠结肠慢波的频率及振幅，采用碘化锌－锇酸法观察肌间神经丛及ICC变化。

A small dose of a hormone, for example, can cause a woman to ovulate, while a larger dose can make her infertile.

例如，小剂量激素可致女性排卵，而更大剂量激素却可导致她不孕。

The changes of muscle protein content and pH values were observed. Results Thymus and spleen coefficients in high and low dosage group were 9.1±2.3, 6.3±1.1, respectively, and those of in the controll were 6.5±1.6, 3.4±0.5.The contents of muscle protein (g/100 g) in high, medium, and low dose groups were 24.68±0.55, 22.48±0.54, 21.22±1.25, respectively, lower than that of the control (31.83±2.36, P.05). Paramorphia of lymphocyte in high dose ciprofloxacin treated group was observed.

结果 对照组胸腺和脾脏系数分别为(9.1±2.3)，(6.3±1.1)mg/g，高剂量组胸腺和脾脏系数分别为(6.5±1.6)，(3.4±0.5)mg/g，与对照组比较，差异均有统计学意义（P.05或P.01）；而中、低剂量组的脾脏指数与对照组比较，差异均有统计学意义(P.05)；环丙沙星各剂量组与对照组比较，肌肉pH值变化不明显；环丙沙星高、中、低剂量肌肉蛋白质含量分别为(24.68±0.55)，(22.48±0.54)，(21.22±1.25)g/100 g，与对照组(31.83±2.36)g/100 g比较明显下降(P.05)；与对照组比较，高剂量组脾淋巴细胞形态异常。

Methods Seventy-five SD rats were randomized into five groups: normal, model, iodine glycerin (20 g/L), high-dose SP (200 g/L) and low-dose SP (100 g/L). The experimental periodontitis rat models were established by ligating molars with steel wire combined with intramuscularly injection of prednisolone (1.25mg, 8 times). Except that the model and normal groups were treated by applying saline, the other groups were treated by applying the corresponding drugs 0.5 mL to the peridentium, tid for 10 days. After treatment, debris index, probe depth and bleeding rate during probing were investigated and the pathological changes of periodontal tissues were also observed.

方法］SD大鼠随机分为正常组，模型组，碘甘油组(20g/L)，舒口散高、低剂量组(200、100 g/L)；采用钢丝结扎牙齿加肌注波尼松龙（l.25 mg/次，共8次）的方法复制大鼠实验性牙周炎模型；药物采用口腔局部涂搽，每次0.5mL，每日3次，10 d为1疗程，模型组与正常组给予等容积生理盐水；检测各组软垢指数、探诊深度、探诊出血阳性例数，并取牙周组织进行病理学检查。

There are different types of personal loans available.

有许多不同类型的个人贷款优惠。

The above mentioned teaching model of spiral rising can be used to avoid rigidness in teaching.

上述螺旋式上升的教学模式，可以避免教学形成模式後的僵化现象。