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Terminalia catappa leave extract also inhibited the signal transduction protein expression of PI3K and phosphorylation of ERK1/2, JNK1/2 and Akt while the expression of nuclear protein NF-kB, c-Jun and c-Fos were inhibited as well.

而我们更进一步萃取其核蛋白，发现核蛋白中 NF-kB、c-Jun 和 c-Fos 的表现也受到抑制。

Results: Following treatment with siRNA 1221, the expression of exogenous CYP17 in HeLa cells was reduced by up to 50%. The CYP17 mRNA expression and androstenedione production of thecal cells were slightly, but not significantly, reduced compared to cell exposed to the non-specific siRNA.

结果：siRNA 1221处理后，HeLa细胞中外源性CYP17的表达显著降低，抑制率达50%，卵泡膜细胞中CYP17 mRNA水平和雄烯二酮产生降低，但与对照组比较，统计学上无显著差异。

There was a positive correlation between each of them and MVD. VEGF expression was positively correlated with lymph node metastasis and C-erbB-2, negatively with ER, PR, PS2 status, thereas no statistical correlation between VEGF expression and age, tumor size, clinical stage.

实验还发现有淋巴结转移组VEGF mRNA水平明显高于无淋巴结转移组，有统计学显著差异（P.01），VEGF mRNA表达水平与ER、PR、Ps2表达呈负相关关系，三种方法测得VEGF表达水平均与C-erbB-2表达呈正相关关系，但却与肿瘤临床分期，患者年龄，肿瘤大小无关。

Finally, Prdm16-deficient brown fat displays an abnormal morphology, reduced thermogenic gene expression and elevated expression of muscle-specific genes.

最后，我们发现PRDM16缺陷的棕色脂肪表现出一种异常的形态学特征，产热基因表达降低，肌特异性基因表达增加。

Finally, Prdm16-deficient brown fat displays an abnormal morphology, reduced thermogenic gene expression and elevated expression of muscle-specific genes.

PRDM16（一种锌指蛋白，已知能够刺激棕色脂肪选择性基因表达）可强有力地调控肌肉与棕色脂肪之间的双向细胞命运转换。

To investigate the expression of T lymphoma invasion and metastasis inducing factor 1 (Tiam 1) in tissues of thyroid carcinoma, and to analyze the relation between its expression and invasion and metastasis of thyroid carcinoma.

王化修，甲状腺癌中Tiam 1的表达及临床意义目的探讨T淋巴瘤侵袭转移诱导因子1的表达与甲状腺癌侵袭转移的关系。方法采用免疫组织化学S-P法检测Tiam1在89例甲状腺癌及其淋巴结转移癌的石蜡组织标本中的表达。

Objective To investigate the expression of T lymphoma invasion and metastasis inducing factor 1 (Tiam 1) in tissues of thyroid carcinoma and analyze correlation of the expression with invasion and metastasis of thyroid carcinoma.

目的 探讨T淋巴瘤侵袭转移诱导因子1（T lymphoma invasion and metastasis inducing factor 1，Tiam 1）表达与甲状腺癌侵袭转移的关系。

Objective: To evaluate the expression of Topo-Ⅱ in hepatocellular carcinomaan and to explore the relationship between the expression of Topo-Ⅱ and biological behavior of HCC.

目的：探讨在原发性肝细胞癌中Topo-Ⅱ的表达以及与原发性肝细胞癌生物学特征的相互关系。

Kangdai Ⅰ has protective function to the damaged neurons and astrocytes: Main results:(1) It has direct protective function to the damaged neurons. It can increase the activity and survival rate, decrease the mortality and the transudation rate of LDH in cultured medium and the strong positive cell count of NOS expression of injured neurons.(2) It has also directly protective function to the damaged astrocytes. It can increase the activity and survival rate and protein content in conditioned medium.(3) It can strengthen the ability of BDNF, GDNF, bFGF, HSP and IL-6expression in damaged astrocytes.(4) It can also strengthen obviously the expressions of NSE, bFGF-receptor and bc1-2, lower the expression of bax and caspase-3.(5) It can indirectly protect and restore the damaged neurons by astrocytes. Because the effect of ACMK (ACM interfered by Kangdai Ⅰ) is stronger than ACM+K (ACM associated with Kangdai Ⅰ).

抗呆Ⅰ号对受损的神经元和星形胶质细胞均具有保护作用：主要表现为：(1)对受损神经元具有直接的保护作用，可提高受损神经元的活性和存活率，降低细胞培养液LDH的漏出率、细胞死亡率和NOS染色强阳性细胞的表达量；(2)对受损的星形胶质细胞也有直接的保护作用，可提高其活性、存活率以及培养液蛋白质的含量；(3)能增强受损星形胶质细胞分泌BDNF、GDNF、bFGF、HSP和IL-6的能力；(4)可明显增强受损神经元对NSE、bFGF的受体和bc1-2的表达，降低受损神经元对bax和caspase-3的表达；(5)抗呆Ⅰ号可通过星形胶质细胞间接地保护和修复受损的神经元，因为在多数实验组中经抗呆Ⅰ号作用的ACM的作用远大于ACM与抗呆Ⅰ号联合应用的作用，统计学上具有显著性差异。

Analysis of these mutants revealed that the expression level of the neutral trehalase gene in RNAi mutant (Ma688 strain) was reduced to 42% of which found in wild-type strain and the over-expression mutant (Ma113 strain) showed approximatlely 2-fold higher levels of neutral trehalase mRNA than that found in wild-type control. Then the transformants Ma688 and Ma113 were chosen for closer examination, including trehalose content, storage longevity , thermotol

利用Northern blot 分析这几个突变菌株中性海藻糖酶基因mRNA 的含量，选择中性海藻糖酶基因超表达2 倍和中性海藻糖酶基因被抑制到42%的两个转化菌：Ma113 和Ma688，将其与出发菌株进行分生孢子内海藻糖含量的测定，孢子储藏

Chinese traditional virtue is humility and wariness,the compliment and praise to the others should be declination

中国人的传统美德是谦虚谨慎，对别人的恭维和夸奖应是推辞。如

We bought this house on the never-never.

我们以分期付款的方式买下这座房子。