药物

The results demonstrate that ACM-A is capable of intercalating between the base pairs of DNA double helix, the π-π electronic overlapping between π-electron of ACM-A and DNA stabilizes the ACM-DNA adduct, and through electrostatic interaction, the trisaccharide interacts with the minor groove of DNA owing to C(3') amino group.

实验结果表明，ACM-A主要以其蒽环平面嵌入DNA双螺旋碱基对之间，发生-等电子间相互共轭，同时药物糖基上C3'位的-N(CH3)2基团带正电荷，易与带负电荷的磷酸骨架产生静电吸引，从而发生沟槽作用，嵌入DNA的小沟区，这是二者之间的主要结合模式。并且，DNA与ACM-A药物原型的亲和力要强于还原后的药物代谢产物。

Results People discovered a kind of new antipsychotics,which is called unclassifiable antipsychotics,such as risperdal olanzapine quetiapine.They keep some basic advantages of clozapine;and they have became the first choice of clinical antipsychotics gradually.

结果 发现新型抗精神病药物，这类药物统称为不典型抗精神病药物，如利培酮、奥氮平、奎硫平等基本保留了氯氮平的一些优点，已逐渐成为精神科临床首选的抗精神病药。

24H treatment group compared with 24h model group: the density of light of HSP70 of the group increased and which of TGF-β〓, is not different with the model group; the density of the light the HSP70 of the Baicalin group increased and which of it the TGF-β〓, increased with the model group; the density of light of the Concha Margatitifera Usta is not different and which of TGF-β〓, increased with the model group; the density of light of the Cholic Acid group is not different and the density of light of it of TGF-β〓 increased with the model group; the density of light of the Hefang Group is not different and which of TGF-β〓 is not different than the model group.

合方治疗脑缺血12小时组缺血脑组织TGF-β1光密度值较缺血12小时模型组无显著性差异（p＞0.05）。本实验结果发现，与单纯缺血12小时、24小时大鼠相比，药物干预组缺血侧大脑皮层TGF-β1免疫反应明显增强，计算机辅助图像半定量分析两组间缺血侧大脑皮层TGF-β1免疫阳性细胞数差异非常显著。说明药物对局灶性脑缺血损伤可能有一定保护作用，其机制可能与诱导脑细胞TGF-β1合成增加有关。然而，药物调控TGF-β1表达，其促TGF-β1表达增强的机制可能是这样的：脑缺血时TGF-β1mRNA表达增加可能与缺氧诱导神经和胶质细胞刺激生长因子表达有关。

Results The relationship between permeability coefficient and oil/water partition coefficient of 17 alkaloidal drugs or drugs containing 2%Azone can be described as following equations.logkp=7.35×10-2-3.079×10-2logk-8.112;logkp(2%Azo)=8.32×10-2-2.68×10-2logk-5.272,respectively.

结果生物碱类药物的经皮渗透系数与药物油/水分配系数的关系式为：logkp=7.35×10-2-3.079×10-2logk-8.112；logkp(2%Azo)=8.32×10-2-2.68×10-2logk-5.272；结论 17种药物的油/水分配系数平均最佳值为2.83，含2%氮酮后的其平均最佳值为3.17。

Nowadays, the medicines using for the prevention and treatment of osteoporosis incluae:(1) medicines using for resisting bone absorption, such asestrogen, calcitoin, biphosphonates etc;(2) medicines using for promoting osteogenesis: fluoride;(3) calciferous medicine and vitamin D;(4) traditional chinese medicine and chinese drugs.

目前，用于预防和治疗骨质疏松症的药物主要有(1)抗骨吸收药物：包括雌激素、降钙素、二磷酸盐等；(2)促进骨形成药物：主要指氟化物；(3)钙制剂和维生素D；(4)中医中药。

The experimental results show:the mineral medicine and the animal medicine which having rigid texture,for example Fluoritum and Carapax Trionycis,should be broken into 60 mesh,added 10 doubl...

试验研究结果表明，质地坚硬的矿物类、角甲类药物，如紫石英、鳖甲在复方汤剂中的煎煮条件为粉碎过60目，加10倍量水，先煎1.5～2小时；毒性药物如附片则先煎30分钟即可达到安全限量；其他需要先煎的药物如麻黄，以先煎2次，每次15分钟为宜。

Based on the security,efficacy,cheapness and easy gain three disinfectant drugs(acids, degerming agents,surface active agents)were chosen to killing coccidial oocysts in chicken.

本试验按照安全、有效、经济、来源容易的原则，从对鸡球虫卵囊有一定抑杀作用的三类消毒药物(酸类、消毒剂类、表面活性剂类)中，筛选了 17组不同药物和浓度的搭配组合，设计了 3个试验：抑制鸡球虫新鲜卵囊孢子化试验；抑杀孢子化卵囊试验；新鲜卵囊和孢子化卵囊经药物处理后感染小鸡试验。

The drug design method based on the target structure is an important means to design lead drugs. Chemogenomics, the combination of combinatory library and high throughput screening accelerates the proceeding of drug research.

摘 要：基于靶标结构的药物设计方法是先导药物设计的重要手段，化学基因组学结合了组合化学和高通量筛选，加快了药物研发的进程。

The IR analyses proved that the polymerization effects really occurred. The BET adsorption test indicated that the adsorption amount of MIPMs to LMD was as three times as that of non-imprinted microspheres. The controlled release test indicated that the release ratio of LMD on NIPMs was linearly increased with increasing time, which suggests that the release process is completely controlled by diffusion. Meanwhile, the release ratio of LMD on MIPMs was curvedly increased with increasing time, which indicates that the release process is controlled by both diffusion and the imprinting effect.

药物扩散实验表明， LMD在非印迹微球上的释药率几乎与时间呈直线关系，说明其释药过程完全受扩散控制；而LMD在MIPMs上的释药率则呈曲线上升趋势，说明其释药过程除了受扩散控制外，还受到药物模板分子与MIPMs之间的印迹效应的协同作用的控制，从而达到了缓释药物分子的目的。

CYP and P-gp mediated PP-CD interactions and the research methods have been discussed in this review.

本文综述了药物代谢酶CYP及药物转运蛋白P-gp介导的植物制剂—化学药物的相互作用及常用的研究方法。

He and Nina moved to California and lived at 2005 Ivar Street, Apt.

他和Nina搬到加州，并在2005年伊瓦尔街，公寓生活。

Droperidol （ potently inhibits transfected HERGchannels and this is the probable mechanism for QT prolongation.

氟哌利多有效地抑制了转染的 HERG 钾通道，可能是 QT 间期延长的机制。