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The group disposed by Acetylspiramycin doesn"t show parallel results; The strip gray scale of exotoxin A decreased gradually with the increasing dosages of Azithromycin and Roxithromycin, which doesn"t show in group disposed by Acetylspiramycin and group PAO-JP2; The strip gray scale of lasR, detected by RT-PCR, decreased gradually with the increasing dosages of Azithromycin, which doesnt show in group PAO-JP2.Conclusions: There were obvious differences between PAO1 and PAO-JP2 in biology characteristics in vitro.

本研究发现大环内酯类药物在生物被膜培养过程中分别处理PAO1、PAO-JP2,结果提示大环内酯类药物(14、15元环)通过对QS系统的影响可有效抑制铜绿假单胞菌生物被膜的形成;通过QS系统有效抑制铜绿假单胞菌的毒力因子的产生,16元环的大环内酯类药物乙酰螺旋霉未见上述结论;lasR基因的反转录结果提示阿奇霉素可在转录水平抑制QS系统发挥其作用。

Prof. Chan is a Professor in the Department of Medicine and Therapeutics at the Chinese University of Hong Kong and a Consultant Physician and Clinical Pharmacologist in the Prince of Wales Hospital, Hong Kong.

陈教授是香港中文大学内科及药物治疗学系教授,香港威尔士王子医院顾问内科医师和临床药理学家,香港中文大学医学系食品与药物安全中心主任,香港中文大学药物研发中心和食品研究中心的重要成员。

In this paper, the micronization of phytosterol particles is researched by the RESS (rapid expansion of supercritical solutions) process.

通过药物颗粒的微细化,降低其粒度,增大比表面积,进而提高药物颗粒的溶解度,可以有效地改善难溶药物的生物利用度。

Treatment recommendations include simplifying the pain regimen, avoiding polypharmacy with its risk of drug interactions, and beginning drugs at lower dosages and titrating upward as needed.

推荐的治疗方法包括给以单一的止痛药物,避免给予多种混合药物以避免药物的互相影响,从低剂量开始给药并根据需要一点一点的增加用量。

It is a leading publication in psychopharmacology offering a wide range of articles reporting on clinical trials and studies,side effects,drug interactions,overdose management, pharmacogenetics,pharmacokinetics,and psychiatric effects of non-psychiatric drugs.

这是一份在精神药理学领域的领头刊物,它刊登文章的范围很广,包括临床试验和研究、副作用、药物相互作用、过量管理、遗传药理学、药物动力学以及非治疗精神病药物的精神病治疗效果等。

They list dofetilide, moxifloxacin, quinidine, sotalol, sparfloxacin and thioridazine, but point out that this list is not exhaustive. 4 A much longer list of QT-prolonging drugs is to be found in table 4.3 in the monograph 'Drugs that prolong the QT interval + Other drugs that prolong the QT interval'.

他们列出了多非利特,莫西沙星,奎尼丁,索他洛尔,司帕沙星和硫利哒嗪,但指出在此列出的并不详尽。4在专题论文的表4.3中有一份长得多的关于延长QT间期药物的列表"延长QT间期的药物+其他能延长QT间期的药物"

Tp the time required for one-half of the atoms in a group of radioactive atoms to decay.

放射性药物radiopharmaceuticals是指药物的本身含有放射性核素,用于人体疾病的诊断与治疗的特殊药物

"Many patients who had lost their response to the drug benefited from re-treatment at intervals shorter than every eight weeks," Hanauer says.

Hanauer说:「很多使用这种药物的患者,在使用这种药物不产生治疗效果后,通过一段少于8周的停药期,可以再次恢复对这种药物治疗的反应。

These are currently in preclinical testing and will rial Panacos' drug, should they both make it to approal.

如果这两家的药物都获得批注,Trimeris这些目前尚处在临床前测试阶段的药物将对罗氏公司的药物形成竞争。

According to senior author Howard Rockman, MD, also from Duke, the physical linkage of the receptors could allow physicians more flexibility in heart failure treatment. Because angiotensin blockers are better tolerated, they could be given alone to patients too sick to take beta-blockers. A single, potent drug targeting both receptors could reduce the need for multiple medications with increased potential for drug interactions and adverse events.

Howard Rockman指出,这些药物在治疗心脏衰竭的成效可以归因于它们并非以单一受体作为目标,这些研究结果也可以为心脏衰竭的患者订作药物疗法,不同受体的补体在不同患者及不同的疾病严重性之间有所差异,所以辨识患者单一性受体组成的血液试验,将可以让内科医生指定最适当药物治疗。

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