形成血管

(1) No blood vessels were found to differentiate and become the lymphatics in the mesentery of fistar rat, and this suggested that the lymphatic might develop from the mesenchymal cells in the tissue. Our results showed the mesenteric lymphatics developed """"""""centripetally"""""""".

结论(1)没有发现肠系膜血管分化形成淋巴管，淋巴管可能发生于血管以外的间充质细胞，即"向心"性发生。

Firstly, the establishment of model requires sophisticated neurointerventional techniques and costly interventional materials(sacculus, minikin circlip ring, endovascular electrocoagulation), it not only consumed time but also increased the resesrch expense ; Secondly, although the Massoud model is the first successful model that contain the nidus, but it is far from mimicking the high-flow fistulae frequently observed in a brain AVM; Thirdly, the rapid spontaneous thrombosis result in fistula occlusion in a short time;Fouthly, the model's natural course and the long–term patency of fistula are unclear;Currently the model is only used for the short-term research.

但Massoud模型目前存在以下主要缺点：第一，模型的建立需要复杂的神经介入技术和昂贵的介入材料(球囊、微弹簧圈、血管内电凝等)，操作费时，又大大增加了研究费用；第二，Massoud模型虽然首次具备了畸形血管团，但它远不是我们临床上常见的含有高流量动静脉瘘的脑AVM；第三，颈动静脉吻合口自发性血栓形成进而导致引流静脉闭塞的机率很高；第四，Massoud模型的长期自然过程和动静脉吻合口的长期通畅性尚不清楚，目前仅仅作为急性期模型。

There are inflammation cells infiltrate, especially around the small blood vessels to form cuffing, which was usually found in the spinal cord under the piamater.

HE染色可见发病小鼠软脊膜下脊髓组织炎性细胞浸润明显，以小血管周围为主的血管袖套形成。

To duplicate quail hyperlipidemia model by ectogenesis cholesterol and high fat forage, induce to atherosclerosis model, observe influence of sugarcane alkane alcohol to model animals' blood fat level, formation of atherosclerosis plaque, pathological changes of coronary vessels and vascular intimal.

用外源性胆固醇和高脂饲料复制鹌鹑高血脂模型，并诱发动物的动脉粥样硬化模型，观察甘蔗烷醇对造模动物血脂水平的影响，对造模动物动脉粥样斑块的形成、冠状血管及血管内膜病变的影响。

Domenstic and abroad academicians have disclosed the influence mechanism of these factors from different aspects, including the gene polymorphism and gene mutation in genetics, which are a susceptible factor for cardiovascular complication in type 2 diabetes patients; the dysfunction of endotheliocyte, the metabolic disorder of lipid, and dysfunction of vascular smooth muscle, which can lead to the formation of arteriosclerosis;the formation of immune complex,which can also accelerate the destruction of artery paries;the sctivation of protein kinase C and the dysfunction of platelet, which may ultimately result in the formation of thrombus and influence the function of cadiac muscle cells.

其中主要包括：遗传学方面的基因多态性和基因突变，二者均是2型糖尿病合并心血管疾病的一个易感因素，内皮细胞功能障碍、脂质代谢异常及血管平滑肌细胞功能异常均可导致动脉粥样硬化的形成；免疫复合物的形成可加速动脉壁的破坏；蛋白激酶C的激活及血小板功能受损最终导致血栓形成并影响心肌细胞的功能。

Results Stable venous thrombus were observed in all inferior caval vein in thrombosis model group, and the proximal part of venous thrombus was unobstructed and consistent with the pathological change of venous thrombosis during acute stage in human body.

结果 采用改良法制作模型后，大鼠下腔静脉内不仅均形成稳定的血栓，而且形成血栓的血管段的近心端保持通畅，符合人体静脉血栓形成急性期的病理演变。

Mallory trichrism staining exhibited light blue samples. Eight weeks following repair, CT showed round blunt defect edges in the coronal position, which had bony pustute connection with gel materials. Density at the defect region significantly increased. 3D reconstruction suggested that defects became small. After hematoxylin-eosin staining, abundant fibrous connective tissue appeared in defect regions, with bony tissues. Mallory trichrism staining revealed that maroon mature bone tissues were found, surrounded by light blue chondroid tissues. Twelve weeks following repair, coronal defect regions were filled with callus. 3D reconstruction showed that defects were repaired. Defect region and surrounding bony tissues had bony connection, with thick bone trabecula and mature Haversian system.

修复后8周，冠状位CT显示缺损边缘圆钝，与凝胶材料有骨性突起连接，缺损处密度增高明显，三维重建显示缺损范围较之前有所减小；标本苏木精－伊红染色后缺损部可见大量含血管成分的纤维结缔组织，有骨样组织结构形成，Mallory三色染色显示有褐红色成熟骨组织形成，其旁边有淡蓝色软骨样组织修复后12周，冠状位CT显示缺损区基本被骨痂填满，三维重建示缺损基本修复；缺损区域和周围骨组织形成骨性结合，骨小梁粗大，哈弗氏系统成熟。

New bone trabecula formation could be observed in experiment group, after 8~12 weeks. There were little blood vessel on periphery.

组织切片HE染色观察见对照组无新骨形成，有纤维包裹，实验组8、12周时有新骨小梁形成，周围有较多小血管形成。

The proliferation and migration of endothelial cells and development of new blood vessels from preexisting ones i...

血管生成是指内皮细胞从已经存在的血管处增殖和迁移并形成新的血管的过程。

Results The AVM animal model was successfully created in seven CEMPs, which was similar to human brain AVM in angio-architecture, angiographic-image, embolizing behavior and post embolization pathological findings. Thromboses were found inside the CJA vessels in 4 animals and in the rest 3 the CJA vessels were shrunk without thrombus.

结果在7只CEMPs中成功制作了AVM动物模型，该模型在血管结构、造影影像、栓塞表现和栓塞后病理改变上与人脑AVM的相似。4只动物颈动静脉吻合口血管腔内有血栓形成，其余3只吻合口血管塌陷皱缩，腔内无血栓。

He and Nina moved to California and lived at 2005 Ivar Street, Apt.

他和Nina搬到加州，并在2005年伊瓦尔街，公寓生活。

Droperidol （ potently inhibits transfected HERGchannels and this is the probable mechanism for QT prolongation.

氟哌利多有效地抑制了转染的 HERG 钾通道，可能是 QT 间期延长的机制。