形成血管

Objective:To make use of endothelial progenitor cell's positive role on the process of angiogenesis.

目的：利用EPCs在血管形成过程中的积极作用，研究其参与肺癌组织的血管形成。

The fine vessel braneh could be found on epineurium and periheurium in 3 days, the capillary network has been formed in the midportion of the nerve segment and spread toward two sides in 7 days, from 14 to 21 days, the capillary network spreaded through the whole grafts and conrected with the capillaries from the two ends.

术后3天，血管已在神经外膜和束膜上形成微小分支。7天移植神经的中段已形成毛细血第四军医大学硕士研究生毕业论文管网，并向两端扩展，而自两端长入的血管则较少。14天至刀天，血管网己分布在移植神经段的全段及各层，并与两端长入的毛细血管相吻合。

Objective:To make use of endothelial progenitor cell's positive role on the process of angiogenesis.

中文摘要：目的：利用EPCs在血管形成过程中的积极作用，研究其参与肺癌组织的血管形成。

Elastic fibers were well-distributed,and vascular endothelial cell did not immigrate.We suggested that expression of ectogenic VEGF triggered paracrine and autocrine of VEGF of chondrocyte and co-acted with VEGF receptor 2 to enhance permeability of chondrocyte and improve internal construct of engineering cartilage,and prevent vascularize proceed.

转VEGF基因软骨细胞作为组织工程的种子细胞与pluronic F-127复合后可于裸鼠体内形成转基因组织工程软骨，与对照组相比，转VEGF基因组织工程软骨具良好的生物学特性，结构均一且与正常软骨组织相似，软骨ECM的GAG、COLⅡ、COLⅩ增多，RunX2、Sox9表达增高，细胞处于增生期的肥大状态，初步分析其原因可能是转染后外源性的VEGF持续表达触发了软骨细胞VEGF自分泌，并通过VEGFR-2作用于软骨细胞，提高了软骨细胞活性，促进其存活与增殖，但未在软骨组织内引起血管内皮细胞的迁移及小血管形成。

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan （the average body weight was 25～30 kg）were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P＜001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P＜001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P＜001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P＜001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系，探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只，平均体重25～30 kg。随机分为3组：正常对照组10只，模型组10只（球囊内膜剥脱加高胆固醇饮食），治疗组10只（球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d）。结果兔髂动脉造影、血管病理图像分析检测结果：①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比，各组之间有显著性差异(P＜001)。②免疫组化分析：模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组（P＜001）；复方丹参滴丸组MMP2、MMP9的表达低于模型组，而TIMP1、TIMP2的表达高于模型组；TIMP1/MMP2、TIMP2/MMP9明显增加，差异有显著性（P＜001）。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896，P＜001)。结论 MMP和TIMP在再狭窄形成中起重要作用；复方丹参滴丸能够明显抑制血管损伤后的内膜增生，可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生，而减少内膜的增生。

People often occur in elderly vascular sclerosis, high blood pressure sustained more easily lead to cerebral arteriosclerosis, vessel wall hyalinization appears fat, thus weakening the strength of the vessel wall, together with the blood of the structure of the wall is relatively weak, the middle vascular myocytes less, the lack of external elastic layer developed arterial adventitia easily occurred in the brain artery wall limitations small expansion, the formation of micro-miliary aneurysm.

人到老年血管常会发生硬化，持续的高血压更容易导致脑动脉硬化，血管壁出现脂肪玻璃样变，从而削弱血管壁的强度，加上脑血管壁的结构比较薄弱，血管中层肌细胞少，缺乏外弹力层，动脉外膜不发达，容易造成脑内小动脉壁发生局限性扩张，形成粟粒性微动脉瘤。

EGFL7 protein is a factor specially secreted by the endothelial cell. It is necessary for formation of vascular lumen, the formation process would be blocked and functions of vascular is incompleted if it is missing.

论文摘要： EGFL7蛋白为一种内皮细胞特异性分泌因子，它是血管管腔形成所必需的因子，它的缺乏将导致管腔形成受阻，从而影响血管功能的完善。

Results Among 6 cases with PCTPV, 4 cases revealed occlusion of the main branch of portal vein at the hepatic hilum, 2 cases revealed occlusion of the common portal vein, and a masslike network of tortuous veins around the hepatic hilum and many small irregular veins radiating from the network to the liver were demonstrated.

结果：6例中4例清楚显示门脉主要分支近肝门处阻塞，2例门静脉主干阻塞，代之以肿块样纡曲血管并在其周围形成向肝性放射状侧支血管影像，以及离肝性侧支循环静脉。6例CT血管成像均能对与分流或断流手术有关的血管解剖提供准确信息。

Methods:By using transmission electron microscope and immunohistochemical technique,oncosis and TSP 1 expression in 57 cases of gastric adenocarcinoma were determined,and the interrelationship between them was studied.

血管形成在实体肿瘤的生长、浸润、转移中起着重要作用，凝血酶敏感蛋白1(thrombospondin1，TSP1)是一种有效的血管形成抑制因子，目前尚未见关于TSP1在胃腺癌中的作用报道。

Results Extensive and diffuse synovial hyperplasia can be seen in patients with RA;synovial pannus formation can be seen in 25 cases.

结果RA组病人均可见广泛、弥漫的滑膜增生，其中25例病人可见滑膜血管翳形成，而OA组仅7例病人可见轻度滑膜增厚，未见滑膜血管翳形成者(X2=55.78P.005)；RA组关节软骨及软骨下骨改变较严重且弥漫，而OA组软骨退变则较局限，且以关节摩擦大的部位受损为著，其软骨下骨改变较为局限，常常见于IV软骨退变；关节腔积液、半月板及韧带改变，在OA组与RA组之间无差异。

He and Nina moved to California and lived at 2005 Ivar Street, Apt.

他和Nina搬到加州，并在2005年伊瓦尔街，公寓生活。

Droperidol （ potently inhibits transfected HERGchannels and this is the probable mechanism for QT prolongation.

氟哌利多有效地抑制了转染的 HERG 钾通道，可能是 QT 间期延长的机制。