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Neutralizing potency of the patent recombinant anti-rabies virus McAbs, SO57 and SOJB,have been investigated broadly to different rabies virus strains in various animal models.100% Chinese Hamsters could be protected by 100IU/kg SO57 against China prevalent street rabies virus named SBD.We firstly established the mouse model to simulate human postexposure prophylaxis by rabies virus and found SO57 had the same function with HRIG against CVS or three China typical street rabies viruses.However,HRIG could not 100% protect the mice challenged with SBD street virus,rabies virus vaccine alone could not save life from rabies virus infection.The cocktail containing SOJB and SO57(1:1) did not do better than SO57 alone.

用不同的动物模型研究了具有专利的重组人抗狂犬病病毒单克隆抗体SO57、SOJB对不同狂犬病病毒株的中和作用,100IU/kg的SO57能100%保护被中国街毒株SBD攻击的中国仓鼠;首次用小鼠模型模拟人体被狂犬病病毒攻击后的治疗情况,在小鼠被CVS及中国街毒代表株攻击后,SO57与HRIG具有相近的对小鼠的暴露后保护作用;同时结果显示HRIG对SBD株攻击的保护率不能到达100%,仅使用疫苗是不能对感染病毒的小鼠百分之百的保护;SOJB与SO57 1:1联合使用未显示比SO57单独使用更好的保护效果。

Virus hasn't cell construction. A lot of simple virus is only made of nucleus acid and protein tegument, so we can regard it as nucleoprotein. A type of virus pill usual has a kind of nucleus acid. After virus infect sensitive host cell, the nucleus acid of virus will enter cell and produce its descendant and new protein by reproduction and expression. Then, the new synthetic virus is made up of descendant that release form cell by regular way. This specific way of reproduction of virus called reproduction.

病毒不具有细胞结构,一些简单的病毒又由核酸和蛋白质构成,故可把它们视为核酸蛋白分子,一种病毒的毒粒内通常只含有一种核酸,病毒感染敏感宿主细胞后,病毒核酸进入细胞,通过其复制与表达产生子代病毒基因组和新的蛋白质,然后由这些新合成的病毒组分装配成子代毒粒,并以一定的方式释放到细胞外,病毒的这种特殊繁殖方式称为复制。

According to the harm degree after virus erupts and consequence, the poison of 10 a serious illness 2007 is ordinal for: U dish virus of verminosis poison, ARP, net swims virus of great robber virus, MSN sexy album, ANI virus, machine dog virus, acting trojan virus, AV killer virus, Real script virus and virus of panda burn joss sticks.

根据病毒爆发后的危害程度和影响力,2007年的十大病毒依次为:U盘寄生虫病毒、ARP病毒、网游大盗病毒、MSN性感相册病毒、ANI病毒、机器狗病毒、代理木马病毒、AV杀手病毒、Real脚本病毒和熊猫烧香病毒。

Vaccinia virus belongs to the poxvirus family and has a double-stranded DNA genome of 192Kb in size. VV contains an envelope and replicates in cytoplasm of the infected cells. VV has a wide host range and infects various mammalian cell lines as well as animals.

牛痘病毒(Vaccinia virus, VV)属於痘病毒科中一拥有192kb双股DNA遗传物质的病毒,会在细胞质中繁殖出具有鞘膜的病毒,进而感染其他不同种的哺乳动物细胞和动物个体。

Objective: To investigate the relationship between herpes simplex virus infection and pregnancy in oviducts.

目的探讨输卵管妊娠与输卵管单纯疱疹病毒(Herpes Simplex Virus,HSV)感染的关系。

Abstract] objective for the purpose of scientific evaluation and improvement on unreasonable parameter of viral inactivation,the dynamics curve of time corresponding to effect by given viral inactivation factor treated to blood plasma product were analyzed.methods aimed at vesicular stomatitis virus, sindbis virus, human immunodeficiency virus, polioviruses, pseudorabies virus,encephalon-yocarditis virus; validate data of viral inactivated on pasteurization of albumin, human rabies immunoglobulin with ph 4, human immunoglobulin and human hepatitis b immunoglobulin for intravenous injection with ph 4/pasteurization,treatment on human fibrinogen and human coagulation factor ⅷ with solvent/detergent and vapor heating at 100 ℃30 min were systemic regularized respectively.the mean and standard deviation also coefficient of variation for virus survival titer in different time were stated, dynamics curve of virus inactivation were made and analyzed.results human albumin pasteurization inactivated vsv and sindbis virus,hrig low ph inactivated vsv and sindbis virus,hrig low ph inactivated hiv virus,ivig low ph/pasteurization inactivated hiv virus,ivig low ph inactivated hiv virus,hbig low ph/pasteurization inactivated vsv,sindbis and polio virus.conclusion suggestion about improvement on unreasonable parameter and standard of virus inactivation is made,cultivate target virus directly from final product by appropriate cell or method to monitoring viral safety of blood plasma product is advanced.

目的 分析血液制品特定灭活因子的时效动力学曲线,科学性地评价与改进不合理的病毒灭活参数。方法系统性整理针对水疱性口炎病毒、黄热病毒、脊髓灰质炎病毒、伪狂犬病毒、脑心肌炎病毒、人类免疫缺陷病毒,人血白蛋白采用巴氏消毒法,狂犬病人免疫球蛋白采用低ph常温孵放法,静注人免疫球蛋白、静注人乙肝免疫球蛋白采用低ph/巴氏消毒法;人纤维蛋白原、人凝血因子ⅷ采用有机溶剂/去污剂与干热法灭活病毒的验证资料,统计3批样品多个取样点的残余病毒滴度均值、标准差与变异系数,制作灭活病毒动力曲线图并进行分析。结果人血白蛋白巴氏灭活vsv与sindbis病毒,hrig低ph灭活vsv和sindbis病毒,hrig低ph灭活hiv病毒,ivig低ph/巴氏灭活hiv病毒,ivig低ph灭活hiv病毒,hbig低ph/巴氏灭活vsv、sindbis与polio病毒。结论建议改进病毒灭活验证标准与不合理的灭活参数;采用终产品样品通过合适细胞或方法直接培养目标病毒来有效监测血液制品的病毒安全性。

Hepatitis C virus is the major etiology of non-A, non-B hepatitis. At present, neither a vaccine nor any effective therapy is available.

丙型肝炎病毒(hepatitis C virus,HCV)是非甲非乙型肝炎的主要病原,目前还没有有效的预防和治疗手段。

This experiment try to investigate the expressions of Epstein-Barr virus latent membrane protein 1(LMP-1),nuclear factor κ gene bindingand the apoptotic index in nasal NK/T cell lymphoma,and probe into the correlation of LMP-1 with NF-κB,AI,analyze their roles in the occurrence and development of nasal NK/T cell lymphomaMethods:From 1999 to 2004 ,26 cases of nasal NK/T cell lymphoma and 10 cases of benign lymph follicle hyperplasia were selected from Department of Pathology in Hospital of Shangdong province .

目的:EB病毒Epstein-Barr virus在鼻NK/T细胞淋巴瘤(nasal NK/T cell lymphoma)的瘤细胞的检出率较高,但其在淋巴瘤发生发展中的确切作用尚不清楚,本研究通过检测鼻腔NK/T细胞淋巴瘤中EB病毒感染潜伏膜蛋白(latent membrane protein-1,LMP-1)与细胞因子κB(nuclear factor κ gene binding,NF-κB)的表达及其细胞凋亡指数(apoptotic index,AI),比较三者间相互关系,分析EB病毒在鼻NK/T细胞淋巴瘤发生发展中的致瘤机制。

In the early days, pathologists called any agent of infectious disease 'virus'.

在早期,植物病理学家把任何侵染性病害的因子,都叫做'virus'。

Objective To investigate the characteristic of Coxsackie virus B on primarily cultured myocardial cells and to expiate the pathogenesis of cardiomyocytes.

目的 观察B组柯萨奇病毒(Coxsackie virus B, CVB)原代心肌细胞中的感染特点,从而研究CVB对心肌细胞的致病机制。

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He and Nina moved to California and lived at 2005 Ivar Street, Apt.

他和Nina搬到加州,并在2005年伊瓦尔街,公寓生活。

Droperidol ( potently inhibits transfected HERGchannels and this is the probable mechanism for QT prolongation.

氟哌利多有效地抑制了转染的 HERG 钾通道,可能是 QT 间期延长的机制。

The Nazi's cruel treatment of the Jews during the Second World War is beneath contempt .

二战期间纳粹对犹太人的暴行极其可鄙。