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Methods: Rabbits whose allogenic thoracic aorta was cross-linked by dye-mediated photo-oxidation (DMP, n=6) were in the DMP group, rabbits whose allogenic thoracic aorta was cross-linked by glutaraldehyde (GA, n=6) were in the GA group, and rabbits whose homogenic abdominal aorta was orthotropically transplanted (OT, n=6) were in the OT group. Then the donor arteries were transplanted in the position of abdominal arteries of rabbits.

以经染料介导光氧化反应处理的家兔胸主动脉为研究对象,以戊二醛处理的家兔胸主动脉以及自体腹主动脉原位移植作为对照,建立家兔胸-腹主动脉移植模型;实验动物观察饲养1个月后,取出标本,通过原子吸收光谱法测定血管组织钙含量,扫描电镜观察血管壁钙化情况。

Methods Rabbits whose allogenic thoracic aorta was cross-linked by dye-mediated photo-oxidation (DMP, n=6) were in the DMP group, rabbits whose allogenic thoracic aorta was cross-linked by glutaraldehyde (GA, n=6) were in the GA group, and rabbits whose homogenic abdominal aorta was orthotropically transplanted (OT, n=6) were in the OT group. Then the donor arteries were transplanted into the position of the abdominal arteries of rabbits.

以经染料介导光氧化反应处理的家兔胸主动脉为研究对象,以戊二醛处理的家兔胸主动脉以及自体腹主动脉原位移植作为对照,建立家兔胸-腹主动脉移植模型;实验动物观察饲养1个月后,取出标本,通过原子吸收光谱法测定血管组织钙含量,扫描电镜观察血管壁钙化情况。

RS- like multinucleated giant cells were generated from Daudi but not from XG2 cells after CD40-mediated cell homotypic aggregation; XG2 cells underwent tight junction coupling.

进一步用透射电子显微镜观察到了这种大细胞,它们大多数有3~10个细胞核,细胞膜完整;而XG2细胞则发生了细胞间&紧密连接&。

One of the most significant applications of this is found in the evolution of the vertebrates, which was mediated by duplications of the hox gene complex.

在由Hox基因复合体复制介导的脊椎动物的进化中,发现了这一论点的一个最有意义的应用。

The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system, such as neurodegenerative diseases, The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

本发明的化合物还可用于预防和治疗TRX-介导的疾病,例如自身免疫性、变应性和炎性疾病,并且用于预防和/或治疗中枢神经系统疾病,例如神经变性性疾病。本发明还提供了包含所述异羟肟酸衍生物的药物组合物以及这些药物组合物的易于依从并且在体内产生治疗有效量的所述异羟肟酸衍生物的安全剂量方案。

These results suggest that the Rho-kinase-mediated pathway plays a crucial role in the ROS production through NADPH oxidase in hepatocytes during the hyperacute phase of reperfusion in vivo.

这些结果表明,在体内再灌注的超急性期,Rho-激酶介导途径通过肝细胞NADPH氧化酶,在ROS生成中发挥着决定性的作用。

The PGFs, for example, basic fibroblast growth factor and transforming growth factor-β〓, mediated the stromal-epithelial interaction through paracrine and autocrine, directly controled the growth, differentiation and apoptosis of prostatic cells and played an important role during the process of BPH. In the present study, the expression of bFGF and TGFβ〓 in normal and hyperplasic prostate were determined with immunohistochemistry and in situ hybridization.

多肽生长因子,如碱性成纤维细胞生长因子和转化生长因子(TGF-β1)以旁分泌和自分泌的方式介导间质-上皮相互作用,直接调控前列腺细胞的生长、分化和凋亡,在BPH发病过程中发挥着重要作用。

Although nitric oxide hyperproduction due to inducible NO synthase is observed in asthma and COPD, nitrotyrosine formation via the reaction between NO and O(2)- in addition to the myeloperoxidase-mediated pathway.

虽然哮喘和COPD患者均存在由诱导型一氧化氮合成酶催化的一氧化氮过度产生,但是,硝基酪氨酸主要通过除髓过氧化物酶介导途径之外的NO和超氧阴离子反应形成。

Isoflavone; imidazole; imidazolyl isoflavone derivatives; microwave-mediated synthesis; antioxidative activity

工程科技I,化学,有机化学异黄酮;咪唑;咪唑基异黄酮衍生物;微波合成;抗氧化活性

Cellular immunologic function mediated by TH1 cells may be associated with the occurrence and development of RA.

TH1细胞介导的细胞免疫可能与类风湿性关节炎的发生发展有关。

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