查询词典 mediated

Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases.

课程涵盖免疫系统的细胞和组织，淋巴球的发育过程，抗原受体的结构和功能，抗原反应过程的细胞生物学以及抗原的呈现，其中包括MHC分子的结构与组合，细胞激素的生物学，白血球和内皮组织的互动关系，以及免疫相关疾病的致病机转。

IL-18-PE38 recombinant immunotoxin expression vector will provide the basis for study on the targeted cytotoxic activity to Th1 cells and may have some potential value in the treatment of Th1 cell-mediated autoimmune diseases.

结论获得了IL-18-PE38融合基因在原核系统的表达，为进一步研究其对Th1细胞的靶向细胞毒性及临床应用奠定了基础。

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

The use of retrovirus-mediated insertional mutagenesis in zebrafish has led to the mutation and rapid identification of hundreds of genes required for embryonic development and cell growth.

运用反转录病毒介导的插入突变技术，在脊椎动物斑马鱼中已经获得了许多影响胚胎发育和细胞生长过程的突变体，并找到了对应的基因。

Agrobacterium tumefaciens-mediated transformation is a new technique for insertional mutagenesis of filamentous fungi, and it has many advantages such as high efficiency、 low cost、 easy operation and good repetition.

DNA插入突变是标记、分离功能基因的有效途径之一，ATMT是丝状真菌遗传转化的一个的新的技术，具有转化效率高、成本低，操作方便和重复性好多重优点。

As a result, PB-mediated insertional mutagenesis permits for the first time the efficient production of mouse mutants for systematical functional analysis of the mouse genome.

PB转座系统第一次提供了在哺乳动物基因组水平高效诱变基因的工具，有助于系统地研究基因功能。

Since interpreting is an interlingual and intercultural communication mediated by the interpreter, it is anchored in a more complicated context of its own.

口译是以口译员为媒介的跨语言跨文化交际，同一般的交际相比有着其自身更为复杂的语境因素。

Agrobacterium-mediated Transformation of an Economically Important Potato Cultivar Using Internodal Stem Explants 汤莉;汤晖;王素英;杨晓丽;Haeng-Soon Lee;Sang-Soo Kwak

g玻色子对100Pd核高自旋态能谱的影响赵行知；石筑一；石筑亚；倪绍勇；童红·以企业评价为基础建构股票投资决策支援系统刘文卿；黄加辉

The rat hindlimb representation of S1 area is likely to have at least 2 patterns of neural circuits on brain slices: one is the intracortical circuit formed by interlaminar connections from layers II-III, and the other is the thalamocortical circuit mediated by afferent connections from layer IV.

相反，在II-III层，同样的强直刺激并未能明显诱导LTP的发生。结论大鼠S1区的后肢代表区似乎存在两种不同类型的神经回路，一种是由层间联系介导的皮层内回路，另一种则是由丘脑皮层传入介导的丘脑皮层连接回路。

Objective To investigate the effects of intrathecal morphine on cell-mediated immunity.

目的观察镇痛剂量吗啡鞘内泵入对大鼠细胞免疫功能的影响。

Panorama Many people are dancing in a large sitting room.

在一个大客厅里，许多人在跳舞。

We fully understand how a microwave oven cooks food, it is first necessary to talk ...

我们充分理解一个微波炉煮的食物，这是首先要谈。。。