药物学

The invention relates to the isolation and preparation of an active fraction from plant Cuminum cyminum, its further purification and standardization as chemically defined entity with their intended use as drug bioavailability enhancer for the drugs belonging to therapeutic categories such as antimicrobial, antifungal, anti-viral, antitubercular, antileprosy, anti-inflammatory, antiarthritic, cardiovascular, antihistaminics, respiratory distress relieving drugs, immunosuppressants, anti-ulcerogenic, anti-cancer, CNS drugs, corticosteroids, nutraceuticals in compositions to be administered orally/parenterally, topically, inhalations, rectally, vaginally in human beings and/or veterinary conditions.

本发明涉及植物孜然芹中的一种活性级分的分离和制备，进一步的纯化以及它作为化学确定实体的标准化，和它作为治疗类药物的生物利用率增强剂的特定用途，这类药物包括如抗微生物剂、抗真菌剂、抗病毒剂、抗结核药、抗麻风病药、抗炎药、抗关节炎药、心血管类药、抗组胺药、呼吸窘迫缓解药、免疫抑制剂、抗溃疡药、抗癌药、CNS药、皮质甾类药、营养制品，它们以组合物的形式通过口服/肠胃外，局部，吸入直肠，阴道施用于人和/或兽医学病症中。

To date, the ealuation of pharmacokineticpharmacodynamic relationships for efficacy among patients with bacteremia has been limited.

迄今为止，利用药物代谢动力学和药效学的关系评价药物治疗菌血症功效的方法仍受到明显限制。

Drugs to combat shyness, forgetfulness, sleepiness and stress are now in or close to clinical trials, not to mention better versions of drugs that have already swept society—what Arthur Caplan, a bioethicist at the University of Pennsylvania, calls "super-Prozacs".

药物与羞怯，健忘，嗜睡，和压力作斗争，现在正进入或接近临床试验，不必体积更好的药物版本，那已经在社会上广泛流传-这是Arthur Caplan，一个宾夕法尼亚大学的生物伦理学家，称之为"超级- Prozacs"。

Plasma levels of atracurium and laudanosine were determined by high-performance liquid chromatography and the concentra- tion-time data were analized pharmacokinetically and pharma- codynamically with software package of MCPKP and Sheiner's principle respectively.

本文以高效液相色谱法测定血浆阿屈宁和Laudanosine浓度，分别以MCPKP软件和Sheiner氏药物效应学模型行药物代谢动力学和药物效应动力学分析。

Genetics can influence the pharmacokinetics and pharmacodynamics of drugs at different levels.

遗传能影响药物在体内不同水平上的药物动力学和药效学。

The drug design method based on the target structure is an important means to design lead drugs. Chemogenomics, the combination of combinatory library and high throughput screening accelerates the proceeding of drug research.

摘 要：基于靶标结构的药物设计方法是先导药物设计的重要手段，化学基因组学结合了组合化学和高通量筛选，加快了药物研发的进程。

Methods: forty nine patients with prostatic cancer, 14 patients at pathologic stage c, 35 stage d, were analyzed retrospectively. twenty one of them were treated by bilateral orchidectomy and castration of drug; twenty three of them were treated by consist castration of drug;five patients were treated by intermittent androgen suppression.

对49例中晚期前列腺癌患者的临床资料进行回顾性分析。49例分为a、b、c 3组，a组21例行双侧睾丸切除+药物去势，b组23例给予持续性药物雄激素阻断，c组5例行间歇性药物雄激素阻断，分析3组的症状缓解率、影像学评价有效率、前列腺特异抗原psa）反应率及1、2、3年的生存率。

He Toh study, conducted by researchers atthe Slone Epidemiology Center and the pharmacoepidemiology programat the Harvard School of Public Health and the Department ofPediatrics at the University of California, San Diego, was notdirectly funded by any organization or company.

oh的研究是由斯隆流行病学中心和哈佛公共健康学院和加利福尼亚大学儿科学部药物流行病学项目的研究人员进行的。San Diego并没有直接接受任何组织或公司的资金支持。

The results summarized as follows:(1)The main pharmacokinetic parameters Tmax was about 2h, Cmax was 8.365, 7.519, 1.871, 6.485, 4.060μg/mL in blood, gill, kidney, liver, and muscle respectively, after oral administration at a dose of 30 mg/kg; while t1/2 were 8.180~23.249h. These showed that the NFLX absorption was rapid after oral administration of NFLX in Scophthalmus maximus, but the residence time in the fish was long.(2) T1/2 were 74.88~200.45h after oral administration at dose of 30 mg/kg for five consecutive days, which showed that the attenuation of NFLX in the fish body was slow and the residue concentration in the kidney was the highest.

另外，本文测定了大菱鲆成鱼体内NFLX的药物浓度，用MCP-KP药动学程序对所得的药物浓度-时间数据进行分析，结果表明：1单次混饲口灌(30 mg/kg体重日)NFLX，药物在大菱鲆体内的达峰时间为2h，血液、腮、肾脏、肝脏、肌肉达峰浓度分别为：8.365、7.519、1.871、6.485、4.060μg/mL，消除半衰期为8.180～23.249h，说明NFLX在大菱鲆体内吸收较迅速，但滞留时间较长。2连续五天混饲口灌(30 mg/kg体重日)NFLX，消除半衰期为74.88～200.45h，说明混饲口灌NFLX在大菱鲆体内消除缓慢，其中以肾脏中残留最显著。

It publishes original research, reviews, opinions and correspondence in systematics and evolutionary and interactive biology. The topics include taxonomic works in zoology, application of systematics in biological control, agriculture, aquaculture, medical and veterinary zoology, cladistics, experimental taxonomy, parasitology, ecology, behavior and the interaction of organisms with their environment.

该杂志主要发表有关系统学、进化和交互生物学的原创性论文、综述、观点以及通讯等，其内容涵盖动物分类学，系统学在生物控制、农学、水产中的应用，药物和畜牧动物学，遗传分类学，实验分类学，寄生虫学，生态学，行为以及生物与环境的相互影响等。

Cynanchum Lingtai apricot production in the average weight 65 grams, the brightly-colored fruit, juicy rich, sweet-sour taste, sweet from the nucleolus, when the late Qing Dynasty famous Shaanxi, Gansu provinces, the Qing imperial court Tongzhi tribute for years.

灵台生产的牛心杏平均单果重65克，果实色泽鲜艳，汁多味浓，甜酸适口，离核仁甜，清末时就驰名陕、甘两省，清同治年间曾为朝廷贡品。

Chenopodium album,Solanum nigrum, and Amaranthus retroflexus were very susceptible to the herbicides. Polygonum persicaria and Abutilon theophrasti were relatively less susceptible to the herbicides, and Lycopersicon esculentum was not susceptible to it. The relationship between reduction rates of weed biomass and PPM values of weed leaves 2,4, and 6 days after treatment was established.

供试的6种杂草对该混剂的敏感性存在显著差异：红心藜Chenopodium album、龙葵Solanum nigrum和反枝苋Amaranthus retroflexus对该混剂最敏感，ED90值分别为47.65、71.67和29.17g/hm2；春蓼Polygonum persicaria和苘麻Abutilon theophrasti敏感，ED90值分别为96.91、114.20g/hm2；而番茄不敏感。