药物学

OBJECTIVE To design and develop a clinical pharmacokinetics and individual drug dosage regimens system CPKDP program for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS According to the principle of population pharmacokinetics and Bayes" formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient"s pharmacokinetic parameters were estimated based on population-average pharm-acokinetic parameters. CONCLUSION CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.

目的为利用临床常规监测的血药浓度数据估算病人的个体药动学参数，优化给药方案，设计、研制了临床药动学给药个体化系统CPKDP程序方法依据群体药动学原理及Bayes公式，CPKDP程序用FOXPRO 2.6和BORLAND C++ 3.1开发，在希望汉字系统UCDOS 5.0平台上运行结果CPKDP程序适用于具有不同药动学特征的多种药物，适用于不同给药途径的单剂量或多剂量给药在群体药动学参数的基础上，结合病人个体特征，以1，2个血药浓度作为反馈，即可拟合估算个体药动学参数，优化给药方案结论经初步应用，CPKDP程序是应用Bayes反馈法开展临床个体化给药工作非常实用的工具

RESULTS The blood biochemistry index of the huanghankang treated group is much lower than others; The RPE thickness of the three groups has no difference; Compare to the positive control group, the Bruch membrane thickness of the huanghankang treated group is thinner.

结果 黄斑康治疗组血脂、血液流变学、丙二醛（maleic dialdehyde，MDA）指标明显低于阳性药物对照组和阴性对照组；黄斑康治疗组与阴性对照组、阳性药物对照组比较，色素上皮（retinal pigment epithelium，RPE）厚度无明显差异；黄斑康治疗组与阳性药物对照组比较，玻璃膜厚度变薄；黄斑康治疗组与阴性对照组比较，玻璃膜厚度变薄。

However, the clinical use of DOX is limited by its severe, cumulative, dose-dependent cardiotoxicity.

功能基因组学技术在新药研发和药物安全性评价中的应用，为药物毒理学家预测药物的毒性和研究毒作用机制提供了崭新的理论和手段。

Both the medical field and the DOH misconceive the prevention and treatment issue; misunderstand the cost/benefit ratio of epidemiological studies on clinical trials, neglect the reminding of women掇 organization; bypass the study of gender analysis and women掇 health; lack the monitoring of the medical ethic, and neglect its basic duty.

本文以历史脉络厘清为何在2002年七月美国国家卫生研究院会停止原本预定十三年目前才进行到第八年的长期追踪研究，表示美国公共卫生与医学界对HRT药物实验的认真与用心，强调药物只适合用於短期治疗而非长期预防用，也看到民间妇女团体和女性主义学者在监督药物不使之滥用的贡献；以此反观国内反应，显示出我国医界或部分卫生署官员对公共卫生流行病学调查的不了解，对相对风险观念的不明白，以及对预防医学的误解，对健康促进的不重视，对妇女团体的排斥，对性别分析和妇女健康的忽视，更缺少药物伦理的监督，也轻忽卫生署应有的职责。

The pathological factors and mechanisms of CM resulting in insomnia are a lot of causes and varied, such as abnormal climatic changes, pestilence infection, seven-emotional-factors stimulation, dietary ignorance, overstrain and stress, functional disorders of yin and yang, qi and blood, and zang-fu organs.

中西医学治疗失眠最主要在於消除导致失眠的各种因素，但仍以药物疗法为主；西医学的失眠药物以安眠药或助眠或抗失眠药物为主，而中医学的失眠药物则以辨证论治的安神宁心为主，在治疗上应当以补正虚、去邪扰、以及调整阴阳、气血、脏腑功能平衡为原则。

Disclosed are compounds of Formula or pharmaceutically acceptable salts or solvates thereof.

本发明公开了式化合物或其药物学上可接受的盐或溶剂化物。

Thus, most pharmacologically active marine natural products can only be isolated in minute yields.

因此，最药物学地活跃海洋自然产品可能只被隔绝 minute出产量。

During the past few years, stem cell research has metamorphosed into distinct and specialized avenues of research.

ebook干细胞实验药物学的手册干细胞研究已经变形成清楚并且专业化的研究的方法。

The root mean square error was found to be 14 cm\+\{-1\} for urea. The assignment of the fundamentals for CO(NH\-2)\-2 and its deuterated isotopomer CO(ND\-2)\-2 were also performed according to the potential energy distributions.

尿素分子的振动光谱研究 [2～ 6] 对探讨该分子的振动电子耦合、激发态光谱和共振拉曼光谱及其在生物学、药物学和材料科学领域的应用有着重要的意义。

The School's graduates occupy positions of biologists, psychologists and research workers at centres specializing in biological, pharmaceutical, medical, veterinarian, agricultural and nutritional research, as well as at teacher-training colleges, higher educational institutions, technical and comprehensive schools, lyceums and gymnasiums.

生物学院的毕业生可成为生物学家，心理学家和生物学，药物学，医学，兽医学，农业和营养学研究中心或师范学校，高校，技工学校，学会和体育馆的科研工作者。

Cynanchum Lingtai apricot production in the average weight 65 grams, the brightly-colored fruit, juicy rich, sweet-sour taste, sweet from the nucleolus, when the late Qing Dynasty famous Shaanxi, Gansu provinces, the Qing imperial court Tongzhi tribute for years.

灵台生产的牛心杏平均单果重65克，果实色泽鲜艳，汁多味浓，甜酸适口，离核仁甜，清末时就驰名陕、甘两省，清同治年间曾为朝廷贡品。

Chenopodium album,Solanum nigrum, and Amaranthus retroflexus were very susceptible to the herbicides. Polygonum persicaria and Abutilon theophrasti were relatively less susceptible to the herbicides, and Lycopersicon esculentum was not susceptible to it. The relationship between reduction rates of weed biomass and PPM values of weed leaves 2,4, and 6 days after treatment was established.

供试的6种杂草对该混剂的敏感性存在显著差异：红心藜Chenopodium album、龙葵Solanum nigrum和反枝苋Amaranthus retroflexus对该混剂最敏感，ED90值分别为47.65、71.67和29.17g/hm2；春蓼Polygonum persicaria和苘麻Abutilon theophrasti敏感，ED90值分别为96.91、114.20g/hm2；而番茄不敏感。