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MethodsA subline of human pancreatic cancer cell line MIAPaCa2 (MIAPaCa23) with high liver metastasis potential was selected and injected through the tail vein to establish a pancreatic cancer model in nude mice with high liver metastasis. The capability of invasion in vitro was evaluated by a transwell chamber system.

方法筛选出高肝转移的胰腺癌细胞亚型MIAPaCa23,用Transwell小室模型观察PESV对MIAPaCa23细胞体外侵袭能力的影响;尾静脉注射MIAPaCa23细胞建立高肝转移率的裸鼠胰腺癌模型,对比PESV和化疗药物吉西他滨以及抗血管生成剂TNP470对裸鼠胰腺癌肝转移的抑制作用。

This process is the result of the imbalance between matrix metalloproteinases zymogen activations and interaction of the active forms with specific tissue inhibitors of metalloproteinases.

本实验以大鼠为模型旨在研究急性胰腺炎中基质金属蛋白酶-2(MMP-2)与基质金属蛋白酶特异组织抑制物-2(TIMP-2)在胰腺组织中的表达,探讨其与急性胰腺炎时器官损伤程度的相关性。

To investigate the relationship between severity of acute pancreatitis and apoptosis of acinar cells.

研究急性胰腺炎时,胰腺炎的严重程度与胰腺腺泡细胞凋亡的关系。

The apoptotic rate of pancreatic acinar is negatively correlated with the severity of disease.

SAP时存在着胰腺细胞凋亡,胰腺细胞凋亡和胰腺的病情变化呈负相关。

Methods:6 of 380 cases of cadaveric renal transplantation complicated with pancreatitis were treated by adopting conservative therapy.

采用保守治疗方法治疗肾移植术后急性及重症胰腺炎6例,其中4例为急性胰腺炎,2例为重症胰腺炎。

Methods The acute edematous pancreatitis and hemorrhagic necrotizing pancreatitis model of rats were induced by cerulein and dextran-110 and endothelin-1 was administered on AEP rats via intravenous injection. Serum amylase, plasma ET and 6-Keto-PGF1α, pancreas hostologic observation were determined.

应用蛙皮素及高分子右旋糖酐造成大鼠急性水肿性和出血坏死性胰腺炎模型,观察血浆内皮素水平及其它相关指标,同时观察外源性内皮素对水肿性胰腺炎大鼠血清淀粉酶、6-Keto-PGF1α及胰腺组织病理形态等的影响。

The application of clotting drug is one of the important factors for recovery of transplanted pancreatic function. Jejunostomy is an important therapeutic measure to prevent the reflux of intestinal juice to the transplanted pancreas in perioperative period. In the follow-up period cathartic drugs are recommended to prevent constipation and reduce the occurrence of acute pancreatitis caused by intestinal fluid reflux.

凝血药物的应用是移植胰腺功能恢复的重要因素之一,空肠造瘘是围手术期预防肠液向移植胰腺返流的重要治疗措施,且移植后随访期建议应用通便药物,预防便秘发生,减少肠液返流引起的急性胰腺炎的发生。

Nerve growth factor; pancreatic cancer; neurotropism; pain

胰腺癌患者的疼痛发生和胰腺癌的嗜神经性与胰腺癌细胞的NGF表达有关,而与肿瘤的分期、分级无关。

Methods: To establish a rat model of pancreaticoduodenal transplantation with venacava endocrine drainage and enteric eccrine drainage. The recipient rats were introperitoneally injected with 15 mg/kg of proline dithiocarbamate in experiment group and with equal amount of normal saline in control group 30 minutes before transplantation.

建立大鼠腔静脉内分泌引流、肠道外分泌引流的动物模型,脯氨酸二硫代氨基甲酸酯组供体胰腺保存在ProDTC的UW液中,受体鼠于移植前30min腹腔注射ProDTC(15mg/kg);对照组供体胰腺仅保存在UW液中,受体鼠腹腔注射等量生理盐水,分别于再灌注后第0、1、3、6、12、24h等时点,处死大鼠,取血后切取移植胰腺

This review briefed the relation between apoptosis and acute pancreatitis, investigated the influence of apoptosis on acute pancreatitic organ damage, and analyzed the relation between apoptosis and inflammatory cytokines, oxidative stress, endoplasmic reticulum stress, Notch factor, aiming at revealing the mechanism of apoptosis in acute pancreatitis.

本文简述细胞凋亡与急性胰腺炎之间的关系,探讨细胞凋亡对急性胰腺炎器官损伤的影响,分析细胞凋亡与炎症因子、氧化应激、内质网应激、Notch因子的关系,从而揭示急性胰腺炎细胞凋亡的发生机制。

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