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METHODS: The acute pancreatitis model was induced by retrograde injection of 50 g/L sodium taurocholate into the bili-pancreatic duct in SD rats. Forty-eight mas-culinity SD rats were randomly divided into 2 groups: the sodium taurocholate group and the operational control group. The serum amylase level and the histol-ogical pathologic changes of pancreas were measured at different time point in each group. The expression of pancreatic CINC protein and mRNA were determined by immunohistochemistry and semi-quantitative reve-rse transcriptase polymerase chain reaction, respectively.

采用向胆胰管逆行注射50 g/L牛磺胆酸钠建立大鼠SAP模型, 48只♂SD大鼠随机分为手术对照组和SAP组,分别检测各组不同时间点血清淀粉酶和胰腺组织病理学改变,用免疫组织化学法和半定量逆转录聚合酶链反应法检测胰腺组织中CINC蛋白和CINC mRNA表达的变化情况。

Objective: To study the clinical and CT characteristics of solid and cystic tumor of pancreas.

目的:探讨胰腺囊实性肿瘤的临床特征和CT表现,提高对胰腺囊实性肿瘤的认识。

Recent study showed that the devitalization of DPC4 gene was present in nearly 50% of pancreatic carcinoma, which interrupted the TGF-βsignal pathway, so inactivation of DPC4 gene maybe one of the most important cause of pancreatic carcinoma. The present study was carried out to clarify the effect of DPC4 gene on human pareatic carcinoma cell line JF305, which can help us understand the growth and proliferation mechanism of pancreatic carcinoma and provide us the practical guidance on gene therapy of pancreatic carcinoma.

最新研究资料表明近一半的胰腺癌存在DPC4(deleted in pancreatic carcinoma)失活,进而使TGF-β信号传导途径中断,失去其对肿瘤细胞的抑制作用,导致细胞过度生长和增殖,因此DPC4的改变可能是胰腺癌发生、发展的重要原因之一[2]。

Objective: To observe the effect of Danshen injection on soluble adhesion molecules in patients with acute edematous pancreatitis and to investigate its action mechanism.

目的:研究复方丹参注射液对急性水肿型胰腺炎患者外周血粘附分子水平的影响,探讨复方丹参注射液治疗急性胰腺炎的机制。

Methods: Acute edematous pancreatitis and acute necrotizing pancreatitis were induced on male Wistar rats.

使用雄性Wistar大鼠建立急性水肿性胰腺炎与急性坏死性胰腺炎动物模型。

Results According to CT findings,they were divided into edematous type (n=46) and necrotic type (n=42).Forteen cases were complicated with infection.Swelling in 75 cases,exudation in 68 cases,necrosis in 42 cases,splenomegaly in 62 cases.

结果 水肿型46例,坏死型42例,其中合并感染14例,均有较典型的CT表现,胰腺肿胀75例,胰周渗液68例,胰腺坏死42例,脾大62例。

Methods we examined the serum level of TNF and TNFR75 in 22 patients with acute edematous pancreatitis,and 10 patients with acute necrosis pancreatitis on the first,third,fifth and seventh day.

对急性充血水肿性胰腺炎组22例和急性出血坏死性胰腺炎组10例病人外周血液TNF及可溶性s-TNFR75浓度在起病第1、3、5、7天进行检测。

We studied the therapeutic effects on actue pancreatitis in the experimental model of acute edematous pancreatitis in rat aiming at the absence of similar report in our country.

针对国内缺乏这方面的研究报道,我们用急性水肿性胰腺炎大鼠模型对bFGF在急性胰腺炎发病的治疗作用上进行试验性的研究。

Chronic pancreatitis is characterized by progressie pancreatic damage that eentually results in significant impairment of exocrine as well as endocrine functions of the gland.

慢性胰腺炎以胰腺的进展性损伤为特征,最终导致腺体的内外分泌功能显著损害。

Recently, nerve control was thought to be very important in the control of pancreatic exocrine secretion, especially vagus and dorsal motor nucleus.

而在胰腺外分泌的神经调控中,迷走神经和迷走神经背核起到了重要的作用,因此本项研究主要就针对这二者进行胰腺外分泌的神经传递机制的研究。

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