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Results: Tyroserleutide can significantly increase the life span of H22 tumor-bearing mice by 50-70% in dosages of 20ug/kg/d-80ug/kg/d,specially the high dosage of 80ug/ml can significantly increase the life span by 69.24%; Tyroserleutide can inhibit the growth of transplanted hepatocellular tumor BEL-7402 in nude mice,the rate of tumor inhibition was25-50% in dosages of 40-320ug/ml ,the inhibition rate of 160ng/ml was 44.03%; Tyroserleutide could inhibit the growth of H22 and BEL-7402 tumor in a dose-dependent manner. Simultaneously, tumoricidal activity of tyroserleutide against BEL-7402 cell line in vitro was observed hinger when compared with the control group(P.05).The inhibition effect of 72hrs was higher than 24hrs,48hrs,96hrs.And specially the high dosage of 160ug/ml can significantly inhibit growth of tumor cell by 19.36%. Tyroserleutide can activated PEM and marked enhance cytotoxicity andphagocytosis functions in vitro and in vivo. The OD values of cytotoxicity were observed hinger when compared with the control group(P.05).The cytotoxicity of macrophages activated by tyroserleutide against BEL-7402 and B16-F10 was 35.58%,61.2% in vitro and21.39%,47.63% in vivo. The cytotoxicity rate of nude mice PEM was 32.86%,73.07% in vivo. Furthermore, tyroserleutide alone could stimulated the production of IL-1B TNF- a and NO by M . Tyroserleutide and LPS could synergistically activated M producing more cytotoxicity effectors. Conclusion: Tyroserleutide had inhibition functions against hepatoma carcinoma .Its possible mechanisms were related to the affect that Tyroserleutide could inhibit tumor cell directively and induce tumor cells apoptosis or death effectively.

结果:酪丝亮肽能显著延长腹水型肝癌H_(22)小鼠的生存时间,给药剂量为80μg/kg/d时疗效最显著,达到69.24%,在20μg/kg/d-80μg/kg/d剂量范围内生命延长率为50-70%,给药剂量与荷瘤鼠生存时间呈现一定量效关系;酪丝亮肽能显著抑制人肝癌BEL-7402移植瘤裸鼠的肿瘤生长,给药剂量为160μg/kg/d时疗效最显著,抑制率为44.03%,并且在40-320μg/kg/d剂量范围内抑制率为25-50%,给药剂量与肿瘤抑制率呈现一定量效关系;酪丝亮肽体外对人肝癌BEL-7402细胞生长有一定的抑制作用,在作用72hrs时各浓度酪丝亮肽对肿瘤细胞的抑制作用较24hrs、48hrs、96hrs明显,其中浓度为100μg/ml时抑制率达19.36%;酪丝亮肽体内外均能增强小鼠腹腔巨噬细胞对肿瘤细胞的杀伤:体外作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强,与效应细胞对照组相比有显著性差异(P<0.05)杀伤率分别达到35.58%、61.2%;体内作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强,与生理盐水对照组相比有显著性差异(P 。05),杀伤率分别达到21.39%、47.63%;裸鼠腹腔巨噬细胞经酪丝亮肤作用后对BEL一7402、B 16一F10杀伤功能明显增强,与生理盐水对照组相比有显著性差异(P.05),最高杀伤率分别达到32.86%、73.07%;酪丝亮肤能增强单核巨噬细胞系统的吞噬功能,吞噬指数与生理盐水组比较有显著性差异(P.05);酪丝亮肤体外作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO,与效应细胞对照组相比有显著性差异(P.05);酪丝亮肤体内作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO,与生理盐水对照组相比有显著性差异(P.05);酪丝亮肤能促进鼠巨噬细胞株R戌W264.7分泌合成IL一1p和NO,IL一1日、NO水平分别在酪丝亮肤作用24hrs、12hrs时达到高峰,酪丝亮肤单独应用能提高巨噬细胞的分泌合成功能,而且酪丝亮肤能与LPS协同作用刺激巨噬细胞的细胞毒效应分子分泌合成。

O the CR and PR patients displayed significant long six months life span in impositive TSGF patients, but the one year life span had non difference.

SGF、CA125、Ft、CEA四项指标联合检测的灵敏度和特异性高于单项指标和三项联合。

The sub-problem optimal way is used to optimize the mutual insert multi-span greenhouse and the optimal result is disposed using iterated algorithm. Through repetitious iterative disposing the optimal result of three kinds of loads to the mutual insert multi-span greenhouse, it is acquired that the arch pipe's diameter is 32mm, the knighthead's diameter 20mm, the mutual distance 60cm and the gradient side pole's horizontal projection distance is 50cm.

采用零阶优化方法对互插式塑料温室的优化计算结果进行多次迭代处理,得到3种工况下的优化结果:拱杆直径为32mm;支撑杆直径为20mm;互插间距为60cm;倾斜侧杆的水平投影为50cm。

This article discusses the problem in three aspects: relation between pensionable age and Chinese average life span and healthy expectancy life span; pensionable age around the world; effects on labor market.

本文分析了几个被广泛关注的因素:中国人口平均寿命与健康预期寿命变化,世界的退休年龄变化趋势以及退休年龄变化对于劳动力市场的影响。

In this paper, basted on the sum-up and investigation of simulation calculation of long-span bridge construction in nation and international, the detailed approach of imitated calculation of long-span CFST arch bridge is given out, and the reason why the general backward analysis is not suitable for the application of the rib-hoisting of CFST arch bridge is analyzed. And an applied method for forward analysis based on iterative theory is put forward.

本论文通过对国内外桥梁施工仿真计算成果的总结和研究,给出了大跨度钢管混凝土拱桥仿真计算的具体步骤,分析了一般的倒退仿真计算方法不适合应用于钢管混凝土拱桥吊装的原因,并为此提出了基于迭代理论的前进分析实用方法。

Now this type of bridge is applied to more and more medium and small-span bridges in cities, even large-span bridges over rives.

目前在我国,越来越多的城市中小型桥梁,乃至跨江河的大桥都采用这种桥型方案。

With the development of science and the improvement of the suspend capacity, there has been a noticeable trend in the enlargement of span range and the standardization of medium and small-span bridge design. But the test researches and the whole loading process analysis on the simply supported continuous P.C.

目前简支连续预应力混凝土多箱式桥梁的应用日趋广泛,随着科技的进步及吊装能力的提高,跨径范围的增大以及在中小跨径领域内设计标准化的趋势十分明显。

As a compress-bend structure, with increasing of the span, length slender ratio and carrying load of arch increase, lateral rigidity and width span ratio of arch ring minish relatively. During construction and service stages, lateral stability becomes more important and a control factor of arch bridge design.

拱肋作为压弯结构,随着跨径的增大,杆件的长细比及所承受的荷载也随之增大,拱圈横向刚度、宽跨比相对减小,在施工阶段及使用阶段横向稳定问题特别突出,常常成为拱桥设计的控制因素。

As a structure that is compressed and bended, with increasing of the span, length slender ratio and carrying load of arch increase, lateral rigidity and width span ratio of arch ring minish relatively. During constructing and bring to bear, lateral stability becomes especially severity and a control factor of arch bridge design.

拱作为压弯结构,随着跨径的增大,杆件的长细比及所承受的荷载也随之增大,拱圈横向刚度、宽跨比相对减小,在施工阶段及使用阶段横向稳定问题特别突出,常常成为拱桥设计的控制因素。

The article is based on the 6m-span girder bridge in the Country Road 312, using ANSYS to analyze the model of no bearing and simple-supported plate girder bridge, which with width-span ratio of 2 and continuous deck.

以国道312线跨径6m的板梁为例,用ANSYS对宽跨比为2且桥面连续的无支座简支板梁桥进行模态分析。

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Chrysanthemum of 10 thousand birthday is lax to edaphic requirement, with the arenaceous qualitative loam with fecund, good drainage had better.

万寿菊对土壤要求不严,以肥沃。排水良好的砂质壤土为好。

He unstepped the mast and furled the sail and tied it.

他拔下桅杆,把帆卷起,系住。

Therefore, positively advances the interest rate marketability reform is one of current our country finance reform important tasks.

因此,积极推进利率市场化改革是当前我国金融改革的重要任务之一。