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血小板

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Methods By a monoclonal antibody immobilization of platelet antigen assay, antiplatelet autoantibodies were detected using monoclonal antibodies specific for glycoproteins Ⅰb,Ⅱb/Ⅲa and P-selectin in patients with ITP and nonimmune thrombocytopenia. Meanwhile, RP% and PAIgG were measured in the same samples with flowcytometry.

通过改良的单克隆抗体特异性捕获血小板抗原试验测定ITP(86例)与非免疫性血小板减少(30例)患者血浆中血小板膜糖蛋白Ⅰb、GPⅡb-Ⅲa以及P-选择素自身抗体,同时以流式细胞术检测相应的RP%及PAIgG。

Prophylactic infusion thrombocyte can not prevent cerebral hemorrhage completely.To preclud the correlated cause may be important measure to decrease the death rate of cerebral hemorrhage with thrombocytopenia.

血小板减少性脑出血预后差,预防性血小板输注不能完全阻止脑出血的发生,控制和消除诱发脑出血的其他相关原因可能是减少血小板减少性脑出血的重要措施。

When normal platelets are stimulated by thrombogen, ADP or collagen, the GPⅡb/Ⅲa receptor on the surface of platelet combine with fibrinogen that induces platelet aggregation.

正常血小板在各种刺激下,如凝血酶原,ADP,胶原诱导下被激活,其表面糖蛋白Ⅱb/Ⅲa受体由配体-非结合状态变为配体-结合状态,导致血小板聚集,形成血小板血栓。

It is concluded that the occurrence of abnormal platelet aggregative function is high in patients with MPD.

MPD患者血小板聚集功能不良发生率高;1例ET患者有RIPA降低和vWF:Rco降低,但其血浆中是否存在vWF多聚物的缺乏,仍需进一步研究证实;研究观察期间未发现止血功能的异常与临床症状的相关性,但MPD患者中血小板功能缺陷的高发生率提示临床使用血小板抑制剂应持谨慎态度。

In the subset of patients not known to take aspirin, 24% had reduced platelet activity. Sixteen (24%) patients received a platelet transfusion 21.2+/-11.4 hours after symptom onset with an increase in platelet activity (448 [414-479] to 586 [530-639] ARU, P=0.001), but without impact on outcomes.

在不知道服用阿司匹林的亚组患者中,24%的患者血小板活性降低。16名(24%)患者在出现症状后21.2+/-11.4小时接受了血小板输注,他们的血小板活性是增加的(448 [414-479] - 586 [530-639] ARU,P=0.001),但是这点对预后无影响。

Our experimentation demonstrates that dauricine inhidits platelet aggregation induced by the threshold concentration of adenosine diphosphate, arachidonic acid and collagen in the dose-dependent way in vitro in rabbits. The aggregatipn inhibition rates produced by dauri- cine 0.08 mg/ml for ADP, AA and Coll are 49.20%, 62.26% and 65.75% respectively.

结果表明,体内外给山豆根硷明显抑制ADP、AA和Coll诱导的血小板聚集,存在剂量依赖关系,在最大聚集率减少的同时:促进ADP、AA诱导的血小板聚集解聚,减慢Coll诱导血小板聚集速度;对三种促聚集剂的抑制无明显选择性。

After the platelet transfusion, the antibodies of all the cases of the homotype platelet transfusion were negative, but the antibodies in 2 cases of the control group were positive, and there was antibody to HPA-3a in one of the antibodies positive cases.

血液病人接受单采血小板输注后,HPA-3同型输注组血小板抗体阴性,而对照组有2例存在血小板抗体,其中1例为HPA-3a抗体。

Objective To study the changes in bone marrow megalokaryocyte numbers, platelet function and T-lymphocyte subsets in children with idiopathic thrombocytopenic purpura after treatment and normalization of platelet count.

目的 研究特发性血小板减少性紫癜患儿经治疗血小板数量正常后的血小板功能、巨核细胞数量及T淋巴细胞亚群的变化。

Platelet α-groin membranin; platelet-suface correlation antibody; chronic hepatitis B; liver cirrhosis after hepatitis B; the function of platelet.

血小板α颗粒膜蛋白;血小板表面相关抗体;慢性乙型肝炎;乙肝肝硬化;血小板功能

Results The results showed that PLT,MPV and PCT were significantly reduced in febile phase, hypotensiveshock phase and oliguria phase.

结果 HFRS患者在发热期、低血压休克期和少尿期血小板计数、平均血小板体积和血小板压积均明显降低。

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