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In this study, the genomic structure and regulatory elements of ApoD from 10 representive species including protozoan, invertebrate, protochordate and vertebrate were analyzed and compared. The genomic structure of ApoD is less conserved in organisms from protostome to deuterostome invertebrates, while it is highly conserved among chordates including amphioxus and verebrates. All four conserved cysteine residues are present in amino acid sequence of deuterostome ApoDs, while there are only two cysteine residues in amino acid sequence of protostomes ApoD. Structure divergence between protostome and deuterostome ApoD proteins suggests their function difference. The majority of regulatory elements are present in nearly all organism ApoD genes ranging from unicellular protozoan to mammals, suggesting that ApoD plays a very fundamental role, and possesses a conserved regulatory mechanism. However, there also exist some specific regulatory elements, which are present only in certain species and may perform some special roles.ApoD mRNA expression in murine NIH/3T3 fibroblasts exposed to various stresses such as as hydrogen peroxide and UV light shows dose-dependent increase. And a fly homolog of ApoD, Glial Lazarillo, whose overexpression results in increased resistance to hyperoxia as well as a extension of lifespan under normoxia and resistance to starvation without altering lipid or protein content.

本文首先从生物信息学角度对分属于原生动物、无脊椎动物、头索动物和脊椎动物类群的10种动物ApoD的基因结构及调控区的调控元件进行分析及比较,发现:(1)ApoD基因外显子-内含子结构从原生动物草履虫到原口动物再到后口动物海胆的进化过程中不保守,但在分析的几种脊椎动物中相当保守;(2)文昌鱼ApoD基因扮演从无脊椎动物到脊椎动物承上启下的角色,可能代表了脊椎动物ApoD基因原型;(3)四个半胱氨酸保守位点在后口动物中都存在,而在原口动物中只存在两个,原口、后口动物ApoD蛋白一级结构上的差异反映蛋白功能上可能也存在一定差别;(4)调控区大多数主要调控元件为不同动物共有,说明ApoD主要功能及其表达调控在进化中相当保守;(5)ApoD基因个别调控元件是随着物种进化而出现并开始发挥相关作用,如SF-1;还有一些调控元件在进化过程中还没有发现其规律,这说明ApoD某些功能和基因表达调控模式可能因物种不同而存在一定的差异。

"We have about 2.47 million estimated cases which is huge in terms of numbers," Health Minister Anbumani Ramadoss told a news conference. In terms of human lives affected, the number is still large, in fact very large.

&我们国家被查出有247万病例,是一个相当大的数字&健康部长Anbumani Ramadoss在一次新闻会议上说,基于其对人生活的危害,这个数字仍然很大,其实相当大。

It was a team made up of geniuses and a sapiential communication. On Apr.27th,at the tea bar on the second floor, we, the core members of MSTC, shared their quite quaint or well-off experience and their tastes in the process of applying for a job.

这是一个精英的团体,这是一场智慧的交流。4月27日晚,在西园二楼茶座,我校微软俱乐部核心会员,以沙龙的形式,和大家分享了他们的相当离奇或相当流畅的求学经历,以及自己在成功应聘中的心得。

Shama says that the quality of the fertilizer brought by Tzu Chi is excellent, and with that, he dances in his fields. His land is now so fertile that Shama says even the harvest after next will be abundant.

沙玛站在稻田中,高兴的手舞足蹈,他说慈济送的肥料品质相当好,他的田地在施肥后变得相当肥沃,相信往后的耕种收成会很好。

The development of quadrangle has deeply historical factor and historical causes and thus seems easy quadrangles have far-reaching effects on the modern architectural design which is the result of chinese traditional culture building's long-time Smriti and result.

四合院的发展有着相当深刻的历史因素与历史原因,同时这个看似简单的四合院又对现代建筑设计有着相当深远的影响,这是我们中国传统文化建筑长久传承与积淀的结果。

Thist paper chooses 90 groups of "Tong_su_yi_xu synonymic words" from "Modern Chinese dictionary ", and divides them into three kinds according to the interpretation method in the dictionary, regards web page of Sohu website as the platform, us.es the search engine to carry on the search of the word , count the frequency that every group"s word appears , and rejects artificially the mistakes appearing in all web pages that can be opened, language fact presented in observation post then carefully (namely the example sentence with this word appearing in the webpage), and find that the 90 groups of "Tong_su__yi_xu synonymic words" except that the meaning of a word is the same, have quite a few of at frequency of utilization and concrete usage for difference: Because people"s use habit and word use the difference on to cause the appearance frequency of the word analogous to or with a wide gap, because of word-building ability, the word collocates, the word overlaps or the language usually overlaps, linguistic context of area and times , the meaning of a word that the word appears are abstract and concrete, semanteme is laid particular emphasis on, the morphological feature-change, etc.

本文从《现代汉语词典》中选取90组同素异序同义词,按词典中的释义方法将其分成三类,以搜狐网站的网页为平台,运用搜索引擎进行词语的搜索,统计下每组词语出现的频率,并将所有能打开的网页中出现的错误进行人工干预,然后仔细观察所出现的语言事实(即网页中出现的含有该词语的例句),发现这90组同素异序同义词除了词义相同之外,有相当一部分在使用频率和具体的用法上还存在着差别:由于人们的使用习惯和词语使用上的差异造成词语的出现频率相当或者相差悬殊,又因为构词能力、词语搭配、词语重叠或语素重叠、词语出现的区域和年代语境、词义抽象与具体、语义侧重、词性变化等方面的差异造成词语使用上的区别。

The original defined adakitesare sodium igneous rocks, they are tonalite, trondhjemite or (plagioclase-rich) granodiorite in whole-rock chemistry; however, the K-rich "C-type" adakite defined by Chinese scholars are potassic igneous rocks, they are granite, quartz monzonite and (alkali feldspar-rich) granodiorite, etc.

最初定义的埃达克岩是钠质火成岩,其全岩化学成分相当于英云闪长岩、奥长花岗岩和花岗闪长岩;而富钾的&C型埃达克岩&全岩化学成分相当于花岗岩、石英二长岩和花岗闪长岩。

The results indicate that the deviation of viscosity concentration is still not acceptable for most of the pigments, although the solid content of pigment slurry is well linear with the reciprocal of the square root of viscosity. Furthermore, the slight fluctuation of solid content which is close to the viscosity concentration can cause significant variation of the low shear viscosity according to the calculation, and result in the uncredible test value of viscosity concentration.

结果表明,尽管颜料悬浮液固含量与黏度平方根倒数的线性关系相当好,但对于相当一部分颜料,由此得到的黏浓度数据偏差仍然不可接受;而且根据测算,在黏浓度点附近,固含量的微小波动会造成低剪切黏度很大的变化,导致黏浓度的测定结果不可靠。

The dipped-fabric layers act as the conductors while the undipped fabric forms the insulator.

浸染过的布料层相当于导体,原始的布料层就相当于绝缘体。

This new type seperator gives a beutiful future for the solving of the problem. Besides of this, the seperation function and structive ameliorations of uniflow square seperator and finned tubes seperator were studied systemly, and with the contrast with other type of separtors, have higher seperation efficiency. The uniflow square seperator can reach a much ligh seperation efficiency when it was ameliorated.

并对新型下排气方形分离器和鳍片管束惯性分离器的分离性能和结构优化进行了系统的研究,在对其它几种分离器研究的同时进行了对比,指出方形下排气分离器在结构优化后可达相当高的分离效率,与常规圆形分离器相当,能承担高倍率循环床的物料循环,结构布置得到极大的简化。

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Since historical times,England ,where the early inhabitants were Celts, has been conquered three times .

从有历史以来,英国,在此地早期居住的是凯尔特人,已经被征服了三次。

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