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With the high sensitivity of biomarker assays,the exposure levels and its biological effect in population exposed to low level carcinogens for a long time can be more directly measured,and the dose-effect relationship between biomarkers and a specific risk can be more accurately descripted The study on biomarker,which still stayed in primary stage,presented good prospect in the field of risk assessment on environmental health In this review,data are summarized on the role of biomarkers that are used for...

利用生物标志物高灵敏的特性,可以直接测量人群长期低剂量的暴露水平及其效应水平,能够较准确地估计生物标志物水平与特定危险性之间的关系,这方面的研究尚属起步阶段,但在环境健康危险度评价中具有很好的发展前景。对生物标志物的选择,其在低剂量致癌物暴露危险度评价中的作用,评价方法或途径及存在的问题进行了总结。

Two main aspects of the research work are as follows:(1) The paper introduces the experimental ice forces on semi-circular breakwaters which is made by State Key Laboratory of Coastal and Offshore Engineering of Dalian University of Technology and calculate the ice value for different radius semi-circular component, based on which it speculates on that horizontal ice value and water level accord with biquadratic polynomial function, meanwhile, the paper analyses incidence of ice heap to horizontal ice value of semi-circular component.

论文的主要工作有三部分:(1)主要介绍大连理工大学海岸和近海工程国家重点实验室所做的物理模拟试验,应用水平冰力计算公式计算了不同半径半圆型构件的冰力值;根据这些数值的分析,推测半圆型构件水平冰力与水位符合四次多项式函数关系;同时分析了碎冰堆对半圆型构件水平冰力影响。

The profile of liver CYP450 induction by DEX in male rat After 4 daily i.p. administering of 0,25, 50 and lOOmg/kg/d DEX in male Wistar rat, it was determined the total CYP450 content, the mRNA and protein expression levels of CYP3A1, CYP3A2 and CYP2B1/2, and the ERD (CYP3A catalytic activity), PROD (CYP2B catalytic activity) and BROD (total CYP450 catalytic activity) in livers.

DEX对雄性大鼠肝脏CYP450的诱导效应雄性Wistar大鼠腹注0、25、50和100mg DEX/kg/d诱导处理4天后,测定大鼠肝脏总CYP450含量,CYP3A1、CYP3A2和CYP2B1/2的mRNA及蛋白表达水平,肝脏红酶素脱甲基酶(ERD,CYP3A活性),苄氧基试卤灵脱乙基酶(PROD,CYP2B活性),苯氧基试卤灵脱乙基酶(BROD,总CYP450活性),结果表明,CYP450含量、ERD、PROD和BROD在DEX多次诱导后都有升高,CYP3A1 mRNA表达水平、蛋白含量和酶活性有明显的升高,剂量效应关系明显;CYP3A2蛋白也有明显升高,而其mRNA表达水平却没有变化,提示CYP3A1和CYP3A2的诱导机制可能不同。

The profile of liver CYP450 induction by DEX in male ratAfter 4 daily i.p. administering of 0,25, 50 and lOOmg/kg/d DEX in male Wistar rat, it was determined the total CYP450 content, the mRNA and protein expression levels of CYP3A1, CYP3A2 and CYP2B1/2, and the ERD (CYP3A catalytic activity), PROD (CYP2B catalytic activity) and BROD (total CYP450 catalytic activity) in livers.

DEX对雄性大鼠肝脏CYP450的诱导效应雄性Wistar大鼠腹注0、25、50和100mg DEX/kg/d诱导处理4天后,测定大鼠肝脏总CYP450含量,CYP3A1、CYP3A2和CYP2B1/2的mRNA及蛋白表达水平,肝脏红酶素脱甲基酶(ERD,CYP3A活性),苄氧基试卤灵脱乙基酶(PROD,CYP2B活性),苯氧基试卤灵脱乙基酶(BROD,总CYP450活性),结果表明,CYP450含量、ERD、PROD和BROD在DEX多次诱导后都有升高,CYP3A1 mRNA表达水平、蛋白含量和酶活性有明显的升高,剂量效应关系明显;CYP3A2蛋白也有明显升高,而其mRNA表达水平却没有变化,提示CYP3A1和CYP3A2的诱导机制可能不同。

In seven out of 9,and 6 out of 13 hens treated with chlorpromazine or cyproheptadine terminated broodiness following drug treatment,blood PRL levels all decreased from high levels on day 2 of broodiness to levels below 20 ng/ml on day 4 and maintained at low levels to day 19 after onset of broodiness.

试验2:7只就巢鸡在就巢的第2、4、9、14和19 d血浆PRL水平维持在200~400 ng/ml之间;9只氯丙嗪处理后终止就巢的7只鸡以及13只赛更啶处理后终止就巢的6只鸡,血浆PRL由就巢第2 d与对照组类似的高水平急剧下降到第4 d小于20 ng/ml,并至第19 d一直处于较低水平

When making the air reading in the burette, the level bottle should be raised so as to bring the liquid in the burette and level bottle to the same level.

当得到滴管中的气体读数,水平瓶应该升高,使滴管中的液体和水平瓶中的液体在相同的水平

Except for 2μmol/L Verapamil,other concentrations ofCAs and CaMAs could decrease mdr1 mRNA expression level of K562/VCRcells,indicating significant difference from those of control group(CAs:P<0.05;CaMAs:P<0.01),but the changes of mdr1 mRNA expression levelcaused by CaMAs had negative dose-responses relationship with CaMAsconcentration(P<0.05),while the changes of mdr1 mRNA expression levelinduced with CAs had no dose-responses relationship with the CAsconcentration.

除〓的Ver外,其它浓度的CAs和CaMAs均可降低K562/VCR细胞mdr1 mRNA表达水平,与对照组相比,存在着明显差异(CAs:P<0.05;CaMAs:P<0.01);并且CaMAs各浓度间引起的mdr1 mRNA表达水平的变化也存在着差异(P<0.05),呈负的量效关系,而CAs各浓度间引起的mdr1 mRNA表达水平的变化无明显差异。

Results The expression of FOS,JUN,bFGF,and VEGF protein of the cere...

结果正常小鼠脑组织FOS、JUN、bFGF、VEGF低水平表达,B组略强。A组脑组织FOS和JUN的表达具有时程的一致性,创伤性脑损伤后3 h达到高峰,12 h以后降至对照水平;bFGF与VEGF分别于创伤性脑损伤后12 h、24 h达到高峰,72 h降至对照水平

Using ultrasonic to measure the thickness of the cholecyst cliff in these patients. At the same time, we measure their breadth of the portal vein and the level of the ascites, and examine the level of ALB、TBil、AST、ALT in blood serum.

采用超声观察178例肝硬化患者的胆囊壁厚度和腹水检查、门静脉宽度、血清白蛋白水平、总胆红素水平以及门冬氨酸氨基转移酶、丙氨酸氨基转移酶水平

Using the equivalent condition under which the limit of a sequence of fuzzy numbers exists in the sense of level convergence, we analyze the structure of the level continuous fuzzy number valued function. On the basis of it, we prove the level continuous fuzzy number valued function on a closed interval exists supremum and infimum and give the precise representation.

利用模糊数序列水平收敛意义下极限存在的充要条件,在分析了水平连续函数结构特点的基础上,证明了闭区间上水平连续的模糊数值函数存在上、下确界,并给出了上、下确界的具体表达式。

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I'm strongly against the death penalty — it's an eye for an eye.

我不赞成死刑——这是以牙还牙的报复行为。

And to get you the support you need, we're enlisting all elements of our national power: our diplomacy and development, our economic might and our moral suasion, so that you and the rest of our military do not bear the burden of our security alone.

并给你们所须的支援,我们正徵召国家所有各种的力量:我们的外交及发展,我们的经济力量与道德劝说,所以你们与其他军人不须要孤独地负起国家安全的责任。

Imagine yourself to be an actor in a play on the stage.

设想你自己是一个演员在舞台上表演。