异常增生的

Base on her clinical history, serial chest films, hyperostosis, and pustular skin lesions, possibility of bone metastasis was excluded and a diagnosis of SAPHO syndrome was made.

我们基於病人的临床症状，一系列的胸部X光片，骨质异常增生与皮肤脓皰。肿瘤转移是可以排除的，而诊断为SAPHO syndrome。

The formation and development of CNV is a complicated pathologic process. Because the abnormal proliferation of choriocapillary endothelial cells plays a key role in formation of CNV, so if we can inhibit the ability of endothelial cells' proliferative active can we inhibit the CNV.

CNV的发生发展是一个复杂的病理过程，其中，脉络膜毛细血管内皮细胞的异常增生为最关键的一环，因此只要能够抑制血管内皮细胞的增殖就有希望能够抑制CNV。

The advanced expression of Filaggrin may start the mechanism of apoptosis ahead of tune and the premature expression of TGK may accelerate the formation of cornified cell membrane,which will speed up the terminal differentiation of keratinocytes.Consequently,the hyperproliferative keratinocytes differentiate and exfoliate.

K17在扁平庆皮损中染色为阴性，而在寻常庆、尖锐湿虎皮损中为阳性，这提示：扁平庆的异常增生比寻常庆、尖锐湿庆要弱，这与扁平庆的临床表现和病理改变相一致；K17与炎尖锐湿疣初期表现症的发生有关，在三种庆的病理改变中，扁平庆的炎症现象最微弱，这与K17的染色阴性相吻合。

Objective To explore the value of routine laboratory parameters in diagnosis of myelo-dysplastic syndromes and differential diagnosis of patients with hypoplastic MDS from chronic aplastic anemia for providing reference standard for primary hospitals.

目的 探讨联合常规实验室检查指标在骨髓增生异常综合征的诊断和低增生性MDS与慢性再生障碍性贫血鉴别诊断中的价值，提供基层单位适用的MDS诊断和鉴别诊断参考方案。

Results:(1) FSN can inhibit secondary joints swelling and multi-arthritis evidently, improve the whole condition of rats; at the same time, it can also lighten the synovial inflammation and hyperplasia of lesion joints distinctly, and prevent the joint cartilage and bone from destruction; the collective efficiency of FSN is better than TWP.(2) FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th / Ts and Thl / Th2 cells balance in peripheral blood, restrain exorbitant TNF- a ? IL-1 produced by PM O , thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF- a mRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflamination and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue,reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage.Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th／Ts及Th1／Th2平衡紊乱，抑制大鼠PHφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th/Ts and Th1/Th2 cells balance in peripheral blood, restrain exorbitant TNF-α、IL-1 produced by PMφ, thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF-αmRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflammation and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue, reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage. Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱，抑制大鼠PMφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

Restraining EC cell's paraplasm, adjust 5-HT's normal secretion is one of the possible mechanism of action of Additional Tong Xie Yao Fang curing D-IBS of Liver Stagnation and Spleen Deficiency Type Patient.

抑制EC细胞的异常增生、调节5-HT的正常分泌，可能是加味痛泻要方治疗肝郁脾虚型D-IBS的作用机制之一；4。

ZGF can effectively inhibite the expression of PCNA and AFP in rat hepatic precancerous lesion tissue, and ZGF has the function of lessening the paraplasm of rat hepatic precancerous lesion tissue.

大剂量正肝方能有效降低大鼠癌前病变肝组织PCNA和AFP的表达，减轻大鼠癌前病变肝组织的异常增生。

The overexpression of Fas can induce psoriasis keratinocyte apoptosis unconventionally and play a role of maintain psoriasis nature of

Fas、Bcl-2、ICAM-1的共同作用形成了银屑病角质形成细胞异常增生、角化不全、凋亡细胞增多和炎性细胞浸润的病理学特征。

① All this suggested that during the hepatocarcinogenesis and the developing stage of liver cancer in a rat its organism never cease to monitor the activities of and eliminate the abnormal cells;② During the precirrhosis and cirrhosis stage,the velocity and extent of tissue proliferation was limited by cell apoptosis.

①大鼠肝癌发生过程中，机体进行细胞增殖以补偿因DEN损害导致肝细胞减少的同时，还通过细胞周期调控机制，以细胞凋亡为表现形式，始终在监测和清除着异常细胞；②肝硬变前期和肝硬变期，机体通过细胞凋亡，使组织增生的速度和规模受到控制。

He and Nina moved to California and lived at 2005 Ivar Street, Apt.

他和Nina搬到加州，并在2005年伊瓦尔街，公寓生活。

Droperidol （ potently inhibits transfected HERGchannels and this is the probable mechanism for QT prolongation.

氟哌利多有效地抑制了转染的 HERG 钾通道，可能是 QT 间期延长的机制。