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乌头碱

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Methods The DNA damage in CHL cells processed by salted aconite root extractive and aconitine by SCGE was detected.

方法采用单细胞凝胶电泳法检测盐附子、乌头碱对CHL细胞DNA即刻损伤的影响。

The acidity of the decoction of the aconite roots and honeysuckle is the weakest, whereas the aconitine is not restrained.

附子与金银花共煎液的酸性是本实验最低的,但中乌头碱未被抑制。

The experimental arrhythmic model was made with Aconitin in rabbits,The Ne-iguan(PC6)point was punctured to observe the influence on recovering time ofarrhythmia.

乌头碱造成家兔实验性心律失常模型,针刺"内关"穴观察对心律失常恢复时间的影响。

Objective To observe the effects of oxymatrine on action potential in normal rats and arrhythmic rats induced by aconitine.

目的:观察氧化苦参碱对正常及乌头碱诱发大鼠心律失常模型动作电位的影响。

The results suggest that veratridine and aconitine induce different firing patterns in injured DRG neurons, which may relate to their inhibitory effects on different binding sites of the sodium channel.

实验结果表明,藜芦碱和乌头碱在受损的背根节神经元可以引发不同的放电模式,这可能与它们结合于钠通道上不同位点的抑制作用有关。

The firing patterns induced by veratridine and aconitine, inhibitors of inactivation gate of sodium channel operating on different binding sites, were compared.

藜芦碱和乌头碱是钠通道失活门的抑制剂,但二者作用于不同的位点,前者结合于D2-S6,后者结合于D3-S6。我们比较了这两种试剂引发的放电模式。

In the same neuron, veratridine (1.5~5.0 μmol/L) caused slow wave oscillations of interspike intervals, while aconitine (10~200 μmol/L) caused tonic firing.

结果发现,在同一神经元,藜芦碱(1.5~5.0 μmol/L)可以引起放电峰峰间期的慢波振荡,即峰峰间期由大逐渐减小,然后又逐渐增大,形成重复的振荡波形,每个振荡持续约数十秒至数分钟;而乌头碱(10~200 μmol/L)则引起强直性放电,即峰峰间期逐渐减小,然后维持在一个稳定的水平。

The main efficacy of lappaconitine is acesodyne.

乌头碱是从高乌头根提取出的主要成分,其主要功效是镇痛。

Methods The experimental arrhythmia models were induced with barium chloride (BaCl2),uabaina and aconitine in rats and cobayaes.The incidence rate and mortality rate of arrhythmia,the emergence time and the duration of arrhythmia induced with BaCl2 were recorded in rats pretreated with CASI (in dosages of 25,50, and 100 mg·kg-1 sublingual vein injection).At the same time,the dosages of uabaina and aconitine were observed when the ventricular premature contraction,ventricular tachycardia,ventricular fibrillation and cardiac asystole were appeard in rats and cobayaes pretreated with CASI (in dosages of 25,50, and 100 mg·kg-1 sublingual vein injection).

制备氯化钡(BaCl2)、哇巴因及乌头碱诱导的大鼠及豚鼠实验性心律失常模型,CASI按25、50、100 mg·kg-1分为3个剂量组,舌下静脉给药1次,不给CASI作为对照组,记录大鼠给BaCl2后心律失常的发生率、出现时间、持续时间及动物的死亡率;观察豚鼠及大鼠出现室性早搏、室性心动过速、心室颤动及心脏停搏时哇巴因及乌头碱的用量。

A method for the synthesis of lappaconitine hydrobromide by the reaction of dibromoalkyl with lappaconitine is presented.

报道了以双溴代烷烃和刺乌头碱合成刺乌头碱氢溴酸盐的方法。

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