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These studies indicate the rationality of our molecular design based on the crystal structure of KARI complex. To obtain more KARI inhibitors with high activities, the molecular docking and 3D-QSAR methods were applied to our further studying of these amidine compounds. Two methods AutoDock3. 0.3 and DOCK4. 0 were used in molecular docking, and the calculate results accord with that of herbicidal tests in general. The CoMFA model from 3D-QSAR analysis provided useful guidance for designing highly active compounds prior to their synthesis.

这些分子作为潜在的KARI抑制剂为基于KARI的农药分子设计提供了有利指导;对部分小分子进行了合成,在除草活性初筛的近三十个化合物中,个别化合物表现出较好的除草活性,其中一个化合物wb1596对油菜和稗草具有较高的生长抑制率,并通过E.coli KARI酶活性抑制试验验证了其KARI酶的作用靶标,此化合物可以作为KARI一个有苗头的抑制剂为后续工作奠定了基础;对发现的有苗头的KARI抑制剂进行了结构修饰和优化,合成了一系列脒类化合物并确证了它们的结构,改造后的化合物与原抑制剂相比大多除草活性相当或更佳,从而表明我们基于靶标结构的分子设计的合理可靠性;对所合成一系列脒类化合物进行了分子对接和三维定量构效关系研究。

It was found that all these compounds are hydrolyzed in different degrees;among which N-(p-chlorophenyl)amidophosphoric acid is the most stable.

而对于不同底物的水解速度与亲和力都不相同,显示磷酸氨基酶活力与底物的结构有密切关系。

Results The serum levels of α 1 Antitrypsin in PHC group were much higher than those in the control groups,and had a signifficant difference comparing with the other liver disease groups.

近年来α1 -AT与消化道恶性肿瘤的研究,在国内外受到广泛重视,α1 -AT与肝癌的关系尤为密切,许多学者认为可将其作为肝癌诊断和临床观察的一种有价值的辅助指标 [1 ,2 ]。

So far as the protection of pioneer investors is concerned, Resolution II of UNCLOS on Governing Preparatory Investment in Pioneer Activities Relating to Polymetallic Nodules (hereinafter referred as "Resolution II") stipulates relevant provisions, and the author orderly discusses the definition of pioneer investors, procedures of application and their rights and obligations. Concerning settlement of disputes on overlaps of mine sites, the Preparatory Commission for the International Sea Bed Authority and for the International Tribunal for the law of the Sea (hereinafter referred as "Preparatory Commission") had held series of meetings or sessions with states interested since 1983, and they had signed the 1984 General Understanding, the 1986 Arusha Understanding and New York Understanding, and the 1987 Midnight Agreement. As a result, such agreements had be settled overlapping disputes of mine sites between the first group of applicants and potential applicants.

关於「先驱投资者」之保护,公约《决议二》:「进行多金属结核开发活动之预备性投资」有相关规定,笔者分别就先驱投资者之意义、申请程序及其权利义务作说明;对於申请矿址重叠冲突之争端解决,「国际海床管理局与国际海洋法法庭筹备委员会」(本文简称为海床筹备委员会)於1983年召集各利害关系国举行一连串会议,并签署1984年《一般谅解》、1986年《阿鲁沙谅解》及《纽约谅解》与1987年《午夜协定》,解决「第一批申请者」及「潜在申请者」矿址重叠之问题,同时於1987年年底批准第一批申请者提出之申请,使其具「先驱投资者地位」。

Jianchaling gold deposit belongs to the epithermal low temperature hydrothermal deposit with the auriferous mineralization strongly associated with the ultra basic rock,and the fault F 45 1 is acknowledged as main controlling structure.

煎茶岭金矿床是属于与超基性岩有密切成因关系的浅成低温热液型矿床,主控断裂为 F4 51 ,与 F4 51 断裂相关的次级断裂和张性裂隙构造是最重要的容矿构造。

The genetic property of Balilla type is controlled by a pair of dominant nuclear genes, and modified by minor genes.

我国北方地区推广种植的直立穗型水稻品种中,有53.3%的品种与巴利拉有亲缘关系。

Erect panicle varieties grown in the north excluding Liaoning province have some relationships with Balilla.

我国北方地区推广种植的直立穗型水稻品种中,有53.3%的品种与巴利拉有亲缘关系。

Kinds of Schiff base derivatives of 2-N-benzylidene Furanmethanamine have been designed. The Net Charges of main atoms, bond lengths, bond angles, dihedral angles, IR have been calculated by means of HyperChem6. 0 program. 36 kinds of Schiff base derivatives of benzylidene adenine have been designed. Also the net charges of main atoms, bond lengths, bond angles, dihedral angles, IR, the energy gap △E between HOMO and LUMO and the nonlinear second-order polarizability β have been calculated by means of HyperChem6. 0 program. The calculated results indicated that the nonlinear second-order polarizability β were up in accordance with the △E down.

设计了腺嘌呤缩苯甲醛36种衍生物,计算了这些分子的气相几何,腺嘌呤缩苯甲醛中各原子的电荷分布,最高占有轨道HOMO和最低未占有轨道LUMO的能量以及它们之间的能量差△E,同时还计算了这些分子的二阶非线性极化率β,我们发现腺嘌呤缩苯甲醛的二阶非线性光学系数与△E有近似一致的变化关系,随着△E的减小,二阶非线性光学系数有增大的趋势。

Afterintroduction of basic electroluminescent theory of polymers and discussion of the studysituation of electroluminescent polymers and polyphenylene vinylene particularly, therelationship among structure, solubility and electroluminescent properties was studiedIn this paper, polyether-type PPV, polythioether-type PPV, and PPV containingoxadizole, biphenylene, or saturated aliphatic unit were synthesized, the monomers andpolymers were characterized as well.

在讨论了电致发光聚合物的基本发光原理并深入地分析了国内外有机电致发光聚合物尤其是聚苯撑乙烯的研究现状与发展趋势的基础上,论文着重研究了PPV衍生物的结构与它的可溶性以及电致发光特性的关系。

It was found that the solubility and oxidative gelation had good correlation with dough and breadmaiking properties. Pentosans with good solubility and oxidative gelation properties had good influence on dough and breadmaking properties.

对小麦麸皮戊聚糖组分与面团特性及面包烘焙品质之间关系进行初步探讨,发现戊聚糖组分的溶解性、氧化交联性质与面团特性及面包烘焙品质之间具有较好的相关性,溶解性较好、氧化交联性质较明显的戊聚糖组分,对面团特性及面包烘焙品质有较好的影响。

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What are your goals and strategies for growth?

你的成长目标和策略是什么?

And unto the angel of the church in Sardis write; These things saith he that hath the seven irits of God, and the seven star I know thy works, that thou hast a name that thou livest, and art dead.

3:1 你要写信给撒狄教会的使者,说,那有神的七灵和七星的,说,我知道你的行为,按名你是活的,其实是死的。

"It is a testament to making sure unemployment compensation is available, making sure we are looking out for people who have lost their jobs," she said.

"这是个实证,证明我们必须确保人们都可以得到失业补偿,确保那些失去工作的人们得到照顾。"