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Electron micrograph showed us that hepatocytes were damaged seriously along with the prolonged NHBD time in A group. At the NHBD 120 and 150min in A group, hepatocytes showed numerous cytoplasmic vacuoles and lysosomes, round swollen mitochondria with clear matrix and rough endoplasmic reticula which was not in a stacked arrangement.

电镜发现，A组随着心跳停搏时间的延长，肝细胞的损伤逐渐加重，至120和150min时，肝细胞内可出现大量空泡和溶酶体，线粒体和粗面内质网结构也遭到破坏，但未出现明显的坏死和凋亡改变。

Histological observation showed that normal structure was observed in all the groups before being harvested or after being preserved for 30 minutes. However, the more severe structure damage was observed in HPCs or hepatic sinusoidal cells with the more prolonged rewarm ischemia.

形态学观察发现，四组供肝于离体前及低温保存30分钟时的组织结构均无明显异常改变；而在复温缺血期间，各组供肝肝实质细胞及肝窦内皮细胞则表现有不同程度的结构损伤，且在程度上也与复温缺血时间呈明显的平行关系。

In group E, which had just experienced 30-minute cold storage without rewarm ischemia, hepatic function could well be recovered in a short time during reperfusion. On the contrary, in group F、G and H, which had experienced rewarm ischemia for 15, 30 and 60 minutes respectively following 30-minute cold storage, hepatic function suffered the more severe damage with the more prolonged rewarm ischemia during reperfusion.

在对供肝复温缺血-再灌注损伤的研究中发现，供肝于再灌注期间，仅低温保存30分钟而无复温缺血的E组供肝功能于短时间内即可得到很好的恢复，但低温保存30分钟后又分别经历15、30、60分钟复温缺血的F、G、H三组供肝，其肝脏功能却遭到了明显的损伤，且复温缺血时间越长者，损伤程度越重。

Although cholestasis of sepsis is often associated with gram-nagetive bacterial infection,it also occurs with a diverse array of other organisms,including Gram-positive bacteria,rickettsial,parasitic and fungal infections.in one study of bacteraemic patients with positive blood cultures only 34% had bilirubin levels greater than or equal to 2.0mg/dl.moreover,in clinical practice the frequency and extent of liver enzyme abnormalities in bacteraemic patients may be far greater than the occurrence of hyperbilirubinaemia.cholestasis appears to be a marker for the severity of sepsis,and prolonged and unresolved cholestasis carries a high mortality.

虽然败血症（sepsis引发的胆汁郁积往往与革兰氏阴性菌（gram-negative bacterial，原文negative瓶错了）感染，它也可能伴随各种各样其他的有机体，包括革兰氏阳性菌（Gram-positive bacteria），立克次体属微生物，寄生虫和真菌感染。一个对菌血症（bacteremic，原文中拼错了）的阳性患者的血液培养分析研究发现其中只有34％的胆红素水平大于或等于2.0mg/dl。而且，在临床实践中的血症患者肝酶异常的发生频率和严重程度可能远远大于高胆红素血症（hyperbilirubinemia，原文中拼错了）。胆汁郁积似乎是一个患有严重性败血症的标志，而且长期的和没有根治的胆汁郁积有很高的死亡率。

It can date back to the ancient Safavi Dynasty in early modern times and has experienced a prolonged and devious development course of over 500 years.

第三方外交&是伊朗传统的对外战略，其内涵丰富、历史悠久，最早可以追溯到近代早期的萨法维王朝，至今已有500多年漫长而又曲折的发展历程。&

Yet, in spite of everything, the schismatical community of Utrecht has prolonged its existence until modern times.

然而，尽管这一切，社会的分裂乌得勒支，延长其存在下去，直到近代。

Second, residues in the reactive site of the inhibitor were replaced by the consensus substrate recognition sequence of furin, namely, Arg at P_1, Lys at P_2, Arg at P_4 and Arg at P_6. In addition, the P_7 residue Asp was substituted with Ala to avoid possible electrostatic interference with furin inhibition. Finally, the extra N and C terminal residues beyond the doubly conjugated disulfide loops were further truncated. However, all resultant synthetic peptides were found to be temporary inhibitors of furin and kexin during a prolonged incubation, with the scissile peptide bond between P1 and P'1 cleaved to different extents by the enzymes.

高活性、低分子量的furin酶抑制剂有可能发展成为新型的抗细菌内毒素和抗病毒感染的药物，我们以绿豆胰蛋白酶抑制剂Lys片段长链22肽为模板，设计了一系列能抑制furin和kexin活性的突变体，采用如下三种方法逐步优化：一、去除Lys片段长链三对二硫键中的一对，用Ser替换Cys，减少可能存在的二硫键错误配对；二、抑制剂的活性中心根据furin底物的专一性逐步改变，即P1、P2、P4和P6位分别变为Arg、Lys、Arg和Arg，同时为了避免P7 Asp和P6 Arg之间可能存在的相互作用，将P7位Asp替换为Ala；三、将两对二硫键形成的双环的外面5个氨基酸残基去除。

In Wistar rats, latent period of a-wave in scotopic rod response after 1-week transplantation was shorten (P.05); and latent period of a-wave in scotopic rod response after 2-week transplantation was prolonged (P.05); while latent period of b-wave in scotopic maximum response after 1-week transplantation was shorten (P.05). In RCS rats, amplitude of a-wave in scotopic rod response and photopic response after 4-week transplantation was increased (PO.05); while latent period of a-wave in scotopic rod response after 4-week transplantation was shorten (PO.05).Conclusion 1. At the age of 3 months, photoreceptors of the RCS rat degenerated completely, which leaded to the reduction of amplitudes of a-wave and b-wave.

Wstar大鼠术后1周的暗适应视杆反应，a波潜伏期缩短o叼。05）；术后2周的暗适应视杆反应，a波潜伏期延长o功刀5）：术后1周的暗适应最大反应，b波潜伏期缩短o功刀5卜＊CS大鼠术后4周的暗适应视杆反应和明适应反应，a波振幅增大o功刀匀；术后4周的暗适应视杆反应，a波潜伏期缩短o＜0卜结论1、RCS大鼠在3月龄时感光细胞变性死亡，导致FERG的a、b波振幅明显降低；视网膜下腔仍存在感光细胞外节盘膜碎屑，外丛状层缺乏感光细胞的突触末端，同时Muler细胞出现反应性胶质纤维增生。

We conclude that subarachnoid block induced by CSE produces greater sensorimotor anesthesia and prolonged recovery compared with SSS.

同时尽管使用相同剂量和比重的局麻药，该组发生低血压和使用血管收缩剂的比例也更高。

In addition, four agents reported the kicking and beating to death of two detainees in Afghanistan who had been subjected to prolonged shackling in a standing position.

此外，四个代理商报道脚踢和殴打致死的两名被拘留在阿富汗谁曾遭受长期shackling在一个一贯的立场。

The quality of both red and white wine depends very much on the wine maker talent and on the quality of the grapes.

他的红酒和白酒的品质，根据酿造者的能力和葡萄的质量，各有差异。

No, I don't want to get drunk before my next match.

" "不，我不想让我的下一场比赛前喝醉了。