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RESULTS: Both resting B cells and T cells did not express PD-L1 on their surface, however PD-L1 expression was significantly up-regulated on the surface of the activated B cells after 6 h stimulation with LPS or pokeweed mitogen, and the percentages of B cells that expressed PD-L1 reached a plateau at 24 h, which were (46.26±10.71)% with LPS and (43.67±6.14)% with PWM stimulation, respectively. No markedly change of PD-L1 expression on the surface of the activated T cells after stimulation with LPS was observed, but upregulation of PD-L1 expression was observed when stimulation with PWM.

结果： 静息B细胞和T细胞表面不表达PD-L1，LPS和PWM刺激6 h后表达PD-L1的B细胞百分率均显著高于静息B细胞，24 h达到最高，分别为(46.26±10.71)%和(43.67±6.14)%，之后随时间延长而降低；表达PD-L1的T细胞百分率在LPS刺激下无显著变化，但PWM刺激6 h后百分率明显高于静息条件，24 h达到最高，为(25.42±9.23)%，之后下降。

Recently, it is proved that SP is also involved in pain modulation, acupuncture analgesia and immunoin- hibition. However, the role of CGRP in them is unclear Therefore, the dy- namic changes of CGRP-, SP-like immunoreactivity and expression ofα- CGRP,β-CGRP mRNAs in dorsal root ganglion and spinal cord in the arthritic rats were observed by using immunohistochemistry and in situ hybridization techniques combined with behavioral tests, respectively. Subsequently, the effects of this peoptide on the develoment of polyarthritis were investigated by intrthecal injections of CGRP and its antagonist in the rats. In addtion, GAL is a novel neuropeptide which coexists with CGRP and SP, but it may play a different role in the primary sensory system. Thus, we also observed the changes of GAL and GAL mRNA in DRG neurons and the spinal cord. The results were as follows

为此本文拟在大鼠佐剂性关节炎模型上，结合行为学测定、用免疫组织化学、原位核酸分子杂交技术观察脊髓背角及DRG中CGRP、SP、α-CGRP mRNA、β-CGRPmRNA的动态变化及电针的影响，此外，用鞘内和外周注射CGRP的工具药探讨了CGRP在佐剂性关节炎发生发展中的可能作用；甘丙肽（Galanin，GAL）也是新近发现的一个神经肽，并与CGRP和SP共存于DRG及初级传入末梢中，在神经损伤模型中脊髓CGRP、SP减少，GAL则明显增加，显示GAL与CGRP和SP的作用可能不同，因此在佐剂性关节炎模型上也同时观察了GAL和GAL mRNA的变化，实验结果如下

Different product ions were observed in positive ion mode, while almost the same product ions were observed in negative ion mode.

结果显示，二者在负离子模式下的碎片相同，而在正离子模式下的碎片裂解不同。

Methods Magnifying endoscope in combination with methylene blue staining were used to observe the micro-structures of gastric mucosa in patients with gastric protrusive erosion. 80 cases with gastric pit types D, E and F were treated with APC-9800. Observed the clinical results and value of APC. One month after treatment, the patients were once more observed under magnifying chromogastroscopy and evaluated clinical effects.

应用放大内镜结合美蓝染色，对胃炎伴隆起糜烂的患者进行胃黏膜细微结构形态学观察，将胃小凹为D、E和F型的80例患者纳入治疗，应用APC9800型氩气刀对病灶进行治疗，观察治疗的临床结果及价值，并于治疗后1月放大染色胃镜复查随访疗效。

Among women with benign breast disease, a non-significant positive association with breast cancer risk was observed for those in the highest quintile of caffeine consumption and a significant association was observed for those in the highest category of coffee consumption .

在妇女良性乳腺疾病，非重大的积极与患乳腺癌的风险，观察这些在最高的五分之一的咖啡因消费和重大关联有人为那些在最高等级的咖啡消费量。

I have observed from cities for 30 years," he writes. Using a refractor "with a 5-inch f/5 Jaegers objective, I have observed 350 of 600 deep-sky objects that I know are possible, most of them many times.

我已经在城市里观测天体30年了，"他写道，"使用一台5英寸的折射镜，我已观测了我所知的500个深空天体中的350个，其中大多数都不只一次。

The training phase lasted 3 weeks, then performance test were carried out. Results: A decline in Respiratory quotient was observed in ketogenic diet fed animals in comparison to chow fed animals (P.05), whilst energy expenditure did not differ. No significant difference were observed in running distance and lasting time.

结果：生酮饲料喂养大鼠的呼吸商显著低于用基础饲料的对照组(P.05)；代谢率略高于对照组，但差异无显著性；生酮饲料干预动物与对照组动物在跑步距离和时间方面的能力差异无显著性。

To produce the scientific evidence for developing and manufacturing new antitumor drugs.Methods: 1 The inhibitory effect on cell growth of Hela was measured by MTT assay in treated or untreated groups (3.125, 6.25, 12.5, 25, 50μg/ml TAM and control) for three different treatment times (24h, 48h and 72h).2 Apoptosis and cell cycle were measured by FCM in four experimental groups (0, 4, 16, 40μg/ml TAM) for 48h.3 Adopting Wright and Giemse's staining to observe the morphology of Hela cells which treated with 40μg/ml TAM.4 Using invasion experiment to detect the Hela cells'invasive abilities which treated with 40μg/ml TAM.5 The protein expressional levels of P-ERK, ERK, C-myc and Cyclin D1 in Hela cells untreated or treated with 4, 16, 40μg/ml TAM for 24h were measured by Western blot.6 Expression of anti-apoptotic gene bcl-2, apoptotic gene bax and MMP-9 in Hela cells of four experimental groups (0, 4, 16, 40μg/ml TAM for 24h), were observed by revers transcription PCR.7 The protein expression of P-ERK, ERK, Bcl-2 and Bax in Hela cells treated with 40μg/ml TAM for 24h observed by laser scanning microscopes.

1采用四甲基偶氮唑蓝法检测不同浓度北豆根总碱(3.125、6.25、12.5、25、50μg/ml)处理不同时间(24、48和72小时)对Hela细胞增殖反应的抑制作用。2采用流式细胞技术(flow cytometry，FCM)检测不同浓度北豆根总碱(0、4、16、40μg/ml)作用48小时，对Hela细胞凋亡及周期变化的影响。3瑞氏-姬姆萨染色后显微镜观察北豆根总碱(0、40μg/ml)作用24小时后Hela细胞形态学变化。4采用Transwell小室法检测北豆根总碱(0、40μg/ml)作用24小时后对Hela细胞侵袭性的影响。5采用免疫印迹方法检测不同浓度北豆根总碱(0、4、16、40μg/ml)作用24小时后，Hela细胞中磷酸化ERK、ERK、C-myc、CyclinD1的表达变化。6采用逆转录-聚合酶链反应(revers transcription PCR，RT-PCR)半定量检测北豆根总碱(0、4、16、40μg/ml)作用24小时，Hela细胞抗凋亡基因bcl-2、促凋亡基因bax、基质金属蛋白酶-9(MMP-9)的表达变化。7应用激光共聚焦显微镜(laser scanning microscope，LSM)观察北豆根总碱(0、40μg/ml)作用24小时后，Hela细胞内P-ERK、ERK、Bcl-2、Bax蛋白的表达变化。

The rhombencephalon does not observed until on the 30th day of gestation and the rhombencephalon angle is about 5 degrees on the 45th day.(4) The eyes of the embryo appeare on the 28th day of gestation. It could be observed clearly with a diameter of approximately 0.5 cm on the 34th day.

3牦牛的菱脑在妊娠第30天时，界限清晰，在第45天时菱脑角约为5度；(4)牦牛在妊娠28天时，眼以眼泡的形式出现，止妊娠的34天时，可以明显的观察到直径约为0.5cm圆形的眼。

CT appearances of both investigative group and control group were analyzed and observed,indicatrix observed included cystic bone destructions,lucent area,"ground glass"-like density,calcification,sclerotic border,internal septation and shape abnormality of bone involved.The data concerned was collected.

分析观察研究组、对照组CT表现，观察指标包括囊状骨质破坏、低密度透亮区、磨玻璃样改变、骨化、边缘硬化、内部分隔、受累骨形态改变，并记录观察数据。

His female bullfighter Lydia gradually Health love, but she was in a vegetative state after the Bulls Zhuangcheng away from her, just because Lydia's ex-boyfriend showed more affectionate than he is like love.

他对女斗牛士莉迪亚渐生爱意，却在她被公牛撞成植物人后离她而去，仅仅因为莉迪亚的前男友表现出好似比他更深情的爱。

I know of none which are not easy to answer, but what I am trying to do now is only by a series of hints to throw some light on the narrow path of legal doctrine, and upon two pitfalls which, as it seems to me, lie perilously near to it.

我不认为有什么难以回答的问题，但我现在要做的仅仅是通过一系列线索，来给法律理论的狭窄路径以及在我看来离它近得危险的两个陷阱提供一些启示。