查询词典 muddle through

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

The clamp device comprises the grip part connected with the clamp part through the linking part, with the clamp part composed of concave part and the first and second arms extended to both sides, the first concave slot horizontally going through the first arm, the second concave slot horizontally through the second arm, a U shape tunnel parallel with the horizontal surface formed by two arms and with the concave part, cylinder hole set inside the top and down side all symmetrical inside the second deep slot, rotary shaft with both ends insertable to the cylinder hole, linking pole component fixed on the rotary shaft, limit component set on the first arm locking the linking pole.

本发明提供一种夹取装置，该装置包括：握持部，夹取部通过连接部与握持部连接；夹取部包括：凹形部，及由其两侧延伸的第一臂和第二臂，构成容置空间；第一凹槽，水平穿设于所述的第一臂，第二凹槽水平穿设于所述的第二臂，分别平行于凹形部及所述两个臂构成的平面，形成U形通道；圆柱形孔，对称设置于第二深槽的上下侧壁内；转动轴，两端可插入所述圆柱形孔中转动；连杆组件，固定于转动轴上；限位件，设置在第一臂上，用于锁定连杆。

These ferments are made of the roofs, leaves and stems of 58 handpicked kinds of plant and vegetables through exclusive the biochemical technology, with the high-reactivity, high-stability and high-safety; The second is the fruit compound ferments(the approval No.J11000510836) with the abundant vitamin, minerals, favorable viable groups, multi-amino acid groups, oligosaccha groups and glucose , is made from handpicked 103 kinds of fruits and 20 kinds of Chinese herbal medicines through microbial treatment and fermentation method; The third is grain and bean high-fiber nutritious ferments (the approval No.J11000600369) with abundant proteases, amyloclast enzyme and lipolytic enzyme, is made from 60 kinds of grains and beans through special biologic technology, and is used to lose weight, expel toxin, clear the bowels, supply nutrition and activate cells in human body.

公司精选台湾58种植物、蔬菜的根、茎、叶天然原料，以独特的生化科技手段研制而成，不仅具有高活性、稳定性和安全性的特点，而且具有耐高温、耐强酸的特点，不含任何添加剂，其活性是当今世界任何厂家生产的酵素都不可比拟的。第二宝是水果复合酵素（检验审核号是J11000510836）。公司精选台湾103种水果，通过微生物科技处理，经半年多时间发酵酿制而成，含有丰富的维生素、矿物质、有益活菌群、氨基酸、果寡糖、葡萄糖等。第三宝是谷豆高纤营养酵素（检验审核号是J11000600369）。公司精选60种谷、豆及种子，用生物科技手段，经过特殊研制而成，含有丰富的蛋白质分解酵素、淀粉分解酵素及脂肪分解酵素。

Focusing on the PGE enrichment mechanism in the basic-ultrabasic intrusions in the Panxi rift, firstly, through the interpretation of TM photograph, data processing of regional geochemical exploration and geophysical prospecting results of gravity, magnetic force and seism, we analyzed the controlling effect of structure and magmatic movement on the PGE mineralization; Secondly, through the study of volcanic apparatus, petrography, measurement of comprehensive geochemical section, isotope tracing and dating of typical PGE-rich melanocratic rock series, we discussed the sources of the PGE-bearing mafic-ultramafic intrusions and basalts, their timing, evolvement sequences, the geochemical processes of magma crystallization and fractionation, and the relationship between magma evolution and structural development; Finally, through the analysis of PGE and chalcophile elements concentrations in the melanocratic rock series and the contrastive study with the Noril''sk magmatic Ni-Cu-PGE sulfide deposit, its related continental flood basalts and Siberia Traps, we discussed PGE mineralization characteristics and its enrichment mechanisms in the melanocratic rock series in the Panxi rift.

本项目首先围绕川西地区主要的PGE矿床及伴生矿的地质环境和有关的地质构造背景，通过TM卫片解译、区域化探和重、磁及地震物探资料分析，总体把握构造及岩浆活动对PGE成矿的控制作用；然后通过对典型富PGE暗色岩套的火山机构地质构造、岩石岩相学、地球化学、同位素定年和示踪等方面的工作，分析本区基性－超基性含矿岩体与喷出岩之间的成岩物质来源、侵入时代及演化序列，研究该区同一岩浆房分异结晶的地球化学过程及其随构造发展的耦合关系；最后通过对暗色岩套PGE地球化学剖面分析以及与俄罗斯诺里尔斯克陆内裂谷溢流型玄武岩中PGE矿化的岩石－构造环境对比研究，探讨该区暗色岩套中的矿化特点和富集部位及其PGE富集机制。

Further more, we discuss four related issues:(1) Through reducing the number of operations in history buffer, we can optimize the efficiency for running continuously;(2) Support Undo operation for collaborative document editor through involving a delete counter for each object;(3) Introduce a new timestamp model to support concurrent operations in a single site for shared data;(3) Through involving a NOOP operation and executing transaction operation with all related NOOP operations to guarantee transaction operation is serialized.

进一步，本文讨论了一致性维护的四个相关问题：（1）通过精简操作的历史队列，实现算法持续执行时的效率优化；（2）通过引入对象节点的删除计数器，实现对文档的协同编著中的Undo操作支持；（3）介绍了一个新的支持单站点上共享数据的并发操作的时间戳模型；（4）通过引入空操作NOOP且保持事务操作和相应的NOOP操作同时执行，保证事务操作的序列化。

September through December, our ninth through twelfth months, were originally positioned as the seventh through tenth months (septem is Latin for "seven," octo is "eight," novem is "nine," and decem is "ten").

从九月份到十二月份，也就是我们的第九个月到第十二个月，起初被定为从第七到第十个月（拉丁语的&septem&意思是七，&octo&意思是八，&novem&意思是九）。

The neutralizing activity of these antibodies and IgG fractions is acquired through post-translational modifications, through opsonization of virus particles into macrophages and immature dendritic cells, or through expression of antibodies on the surface of HIV-1-susceptible cells.

这些抗体或IgG片段的中和活性可以通过抗体分子翻译后的修饰，或介导巨噬细胞和未成熟树突状细胞的对病毒颗粒的调理作用，或者通过表达在HIV易感细胞表面来体现。

In order to solve these problems, first, activated carbon which was deashed by hydrochloride was modified through using concentrated sulfuric acid, concentrated nitric acid, hydrogen peroxide and potassium permanganate in the paper, the result showed that the modification of activated carbon is best through using concentrated sulfuric acid under 250℃ through analyzing the desulfurization efficiency and acidic oxygenous group on surface.

对上述问题，本文首先采用浓硫酸、浓硝酸、双氧水和高锰酸钾等氧化剂对盐酸脱灰后的活性炭进行化学改性，通过对改性活性炭的脱硫效果及其表面酸性含氧基团分析，得出在250℃的温度下采用浓硫酸改性活性炭效果最好。

The experimental group corneas were preserved by organ culture for 4 weeks, the corneal thickness was measured with ultrasonic corneal pachymeter. Then every corneas were divided into half -chip, there are 48 half-chip total. It was divided into 4 groups, there are 12 half-chip in every groups. The corneal endothelial cell density of 12 half-chip were counted through Alizarin Red-Trypan blue staining; 12 half-clip corneas were fixed with 4% neutral formalin solution, HE staining was performed, the expression of AQP-1 in corneal stroma and corneal endothelial cell were detected through immunohistochemical staining; Na~+-K~+-ATPase activities in 12 half-clip corneas were examined with Na~+-K~+-ATPase kit; the expression of AQP-1 mRNA were detected through real-time fluorescent quantitation PCR.

实验组经器官培养保存4周后以角膜测厚仪测量角膜厚度，然后每个角膜被分成两半，共48个半片角膜，再分成4组，每组12个半片。12个半片用茜素红-台盼蓝染色染色行角膜内皮细胞计数；12个半片角膜用4%中性福尔马林溶液固定行HE染色、应用免疫组化染色检测AQP-1在角膜基质和内皮细胞表达的改变；12个半片角膜用Na~+-K~+-ATP酶试剂盒测量角膜内皮细胞Na~+-K~+-ATP酶活性；12个半片角膜用实时荧光定量PCR检测AQP-1mRNA表达改变。

The general situations of the eye were observed and the corneal thickness were measured with ultrasonic corneal pachymeter after the animal models was established. After a week, the corneas were removed after the experimental animals are put to death. The corneal endothelial cell density of 12 half-chip were counted through Alizarin Red-Trypan blue staining; 12 half-clip corneas were fixed with 4% neutral formalin solution , HE staining was performed, the expression of AQP-1 in corneal stroma and corneal endothelial cell were detected through immunohistochemical staining; Na~+-K~+-ATPase activities in 12 half-clip corneas were examined with Na~+-K~+-ATPase kit; the expression of AQP-1 mRNA were detected through real-time fluorescent quantitation PCR.

术后观察眼球大体情况、测量角膜厚度。1周后处死实验动物取角膜，用茜素红-台盼蓝染色染色行角膜内皮细胞计数；用4%中性福尔马林溶液固定行HE染色、应用免疫组化染色检测AQP-1在角膜基质和内皮细胞表达的改变；用Na~+-K~+-ATP酶试剂盒测量角膜内皮细胞Na~+-K~+-ATP酶活性；实时荧光定量PCR检测AQP-1mRNA在角膜内皮细胞表达的改变；并于正常对照组角膜比较。

There had been a moment during the breakfast meeting, though, after the backslapping and the small talk and when all of us were seated, with Vice President Cheney eating his eggs Benedict impassively and Karl Rove at the far end of the table discreetly checking his BlackBerry, that I witnessed a different side of the man.

那次早餐会期间，在表示过关心和寒暄以后，我们所有人坐了下来，我注意观察了一下，副总统切尼面无表情地吃着班尼迪克蛋（Eggs benedict，源自美国，以英式松饼、火腿、水煮蛋以及荷兰酱组合而成），卡尔。罗夫在餐桌的远端谨慎地经常查看他的黑莓手机，我目睹了他所不为人知的一面。

Talk Undelete failed; someone else may have undeleted the page first.

Talk 无法删除选定的页面或图像（它可能已经被其他人删除了）。