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Results:(1) Progesterone-treated models showed intact nasal mucosa, regular ciliary lining and inactive glands;(2) Untreated or normal saline treated models showed disrupted mucosa, inverted cilia and massive mucosal infiltration of neutrophils;(3) Smearing of nasal discharge revealed limited vs abundant number of neutrophils in SD models treated with progesterone vs untreated or treated with normal saline.(4) Hoechst stain: significantly fewer apoptotic cells per field were found in progesterone-treated models (1.583 ± 0.28) compared with untreated or normal saline treated models (2.85 ± 0.285 and 4.8 ± 0.715, respectively).

结果：(1)用黄体酮滴鼻液治疗的SD大鼠鼻腔黏膜上皮完整，纤毛整齐，腺体开放不多；(2)用或不用生理盐水滴鼻液治疗的SD大鼠鼻腔黏膜上皮纤毛倒伏，上皮结构散乱，上皮层大量中性粒细胞浸润；(3)鼻腔分泌物涂片示黄体酮滴鼻液治疗的SD大鼠有少许中性粒细胞，而用或不用生理盐水滴鼻液治疗的SD大鼠鼻腔分泌物含有大量中性粒细胞；(4)Hoechst染色：用黄体酮滴鼻液治疗的SD大鼠鼻腔黏膜上皮凋亡细胞数［(1.583±0.28)/视野］明显少于用或不用生理盐水滴鼻液治疗的SD大鼠［分别是(2.85±0.285)/视野和(4.8±0.715)/视野］。

Methods Antipyretic action of CSC was observed on rabbit fever models induced by lipopolysaccharide and rat fever models induced by baker's yeast. Rat models with pedal swelling induced by carrageenin, mouse models with auricle swelling induced by dimethylbenzene and mouse models with celiac capillary hyperpermeability induced by acetic acid were used to observe the anti- inflammatory action of CSC. Its acute toxicity in mice was also evaluated.

方法］采用细菌脂多糖致家兔发热、啤酒酵母致大鼠发热动物模型，观察穿心莲软胶囊的解热作用；采用角叉菜胶致大鼠足肿胀、二甲苯致小鼠耳肿胀和醋酸致小鼠腹腔毛细血管通透性增加的动物模型，观察穿心莲软胶囊的抗炎作用，并对小鼠进行该制剂的急性毒性试验。

But going with the power system"s development, many new excitor models, PSS models, turtine models, governor models and boiler models appear. It"s not satisfied to increase new interior models in model library. Furthermore openness is a basic characteristic of DTS. So it is very important to constitute a very high efficient, convenient and universal tool for users who can set up new models by themselves.

然而随着电力系统的发展，各种新型的励磁系统模型、PSS模型、原动机模型、调速器模型、锅炉模型不断出现，继续在模型库中新增固定模型的做法显然难以满足众多用户的要求，而DTS的一个基本要求就是开放性，因此建立一个高效、方便的通用平台，以方便用户自行构建动态仿真的模型就显得非常重要。

As the application of the intermediate models is concerned, the works applying the intermediate models to investigate the topographic boundary layer, frontogenesis and low-level frontal structures, and the boundary layer jet are summarized in this article. It is mainly focused on the dynamic characteristics of the Ekman layer and its effect on the low-level structure and circulation of the weather systems illustrated by the models. It is shown that the intermediate boundary-layer models have great potential in illustrating the low level structures of the weather and climate systems as they are coupled with the free atmospheric models.

对于这些Ekman边界层近似理论模型的进一步应用问题，主要回顾和总结了利用上述模型探讨地形边界层结构、大气锋生过程、低层锋面结构和环流以及边界层日变化、低空急流形成等动力学问题的研究，并对这些研究所揭示的Ekman层动力学特征及其对自由大气低层运动的影响进行了分析，结果表明，这些Ekman边界层近似模型可以较好地揭示大气边界层动力学特征，在大气边界层动力学及其与自由大气相互作用的研究上具有重要价值。

The absolute solution of Jiaojia ERP is put forward, the system models are established, and the solution are explained in detail. The business program of Jiaojia gold mine is reengineered based on the theory of "business centers", and the program-oriented compressed organization is framed. The index group and the solution of mine total quality management are setup. Then the optimize program of SCM and its components are designed on the guidance of "Horizontal Integration". The data of Jiaojia gold mine are reengineered based on the data warehouse technology. The information integration can be available after the establish of the business oriented databases, the subject integration oriented data marts, the application oriented data warehouses, the code databases and metadata, as weil as the OLAP system. The mathematics models and data mining modes are set up to function for the decision support of ERP system. The model of programming Master Production Schedule driven by geological resources and marked is figured out, so as to the models for material requirements planning and other decision supports are set up. The models provide service in forms of model storehouse, method storehouse, and algorithm tools center. The agent center is introduced to process the models' organizing, service, as well as self-study. The function system of Jiaojia gold mine ERP is figured out. By combining the development characteristics of Clients/Server and Browse/Server, the general framework and every sub systems are described in detail, including the function, structure, arrangement, modality, and so on.

主要内容如下：（1）深入论述了黄金矿山实施ERP的可行性，并结合应用需求将ERP理论在深度和广度上进行了拓延，建立了黄金矿山ERP系统的理论基础：以资源与市场共同驱动的供应链管理；黄金矿山的双重物流体系；以地质资源有效利用为目标的生产控制体系；黄金矿山财务管理的成本控制核心理论等；（2）提出焦家金矿ERP系统的整体解决方案，构建ERP系统模型，并进行了细节方案的设计：基于"作业过程核心"理论重新规划焦家金矿的业务流程，在此基础上设计面向流程的"扁平化"组织机构；建立了矿石全面质量管理的指标体系和实施方案；以"横向一体化"为指导思想，提出供应链管理各组成部分的全面优化方案；（3）以数据仓库技术为核心完成焦家金矿的数据规划，分别建立面向业务的数据库、面向主题集成的数据集市和面向主题应用的数据仓库，设计代码数据库和元数据库，定义OLAP方式，实现焦家金矿的全面信息集成；（4）针对ERP系统中的决策支持功能，建立了相应的数学模型和数据挖掘模型，提出了地质资源和市场共同驱动的主生产计划模型制定过程，进一步建立了物料需求计划的线性规划模型，以及其它决策支持模型；提出以模型库、方法库和算法工具为核心的模型服务方式，并设计了代理机制完成模型的组织、服务和自学习过程；（5）构建焦家金矿ERP系统的功能体系，针对C/S和B/S模式系统的开发特点，分别对功能体系架构以及各子系统的功能、结构、层次和形式进行详细设计。

Generalized linear models, which can model a large variety of data, have a wide area of application. The class of GLMs includes, as special cases, linear regression, analysis-of-variance models, log-linear models for the analysis of contingency tables, logistic models for binary data in the form of proportions and many others. Usually, the parameters in the generalized linear models are estimated by the method of maximum likelihood . But, in the literature, the nonrobustness of the maximum likelihood estimator forβhas been studied extensively. The quasi-likelihood estimator of the parameter of the generalized linear model shares the same non-robustness properties.

广义线性模型，可用于对多种类型的数据进行建模，是应用非常广泛的模型，线性回归模型、方差分析模型、用于列联表分析的对数线性模型和逻辑斯谛模型等都是广义线性模型的特例，通常，我们用极大似然的方法估计广义线性模型中的参数，但是，在文献中，对参数β的极大似然估计的非稳健性已经有了广泛的研究，广义线性模型的拟似然估计也显示了非稳健性。

On this basis, according to historical data, apply ANN and differential simulation method to get the quantitatively correlative relations between each production and its own influence factors, and introduce the new methods of prediction for dynamic indexes with gas-field development (The combinatorial prediction method based on fuzzy comprehensive evaluation, the method of ANN to select optimally combinatorial prediction models and the ANN prediction method based on genetic algorithm).(2) Base on mathematical programming, combine with quantitative economics and techno-economics, introduce economical indexes to establish production"s distribution optimal model, production"s constitution optimal model and measured production"s constitution optimal model, including multi-objective models and five-years models. Upon this, the optimal project for all gas field and each gas-collected factory can be got. Also, introduce the time value of capitals to improve on these models.(3) Base on the optimal solution theory and algorithm theory for the nonlinear programming problem, introduce the SUMT algorithm and genetic algorithm to study how to solve the models, and on the basis of normal genetic algorithm, make use of auto-adaptively modulating method to improve on normal genetic algorithm; Base on algorithm"s convergence theory and calculation"s complexity theory to analyze seriatim SUMT algorithm"s convergence and genetic algorithms convergence, and compare performance with each other.

在此基础上，利用神经网络方法和微分模拟方法根据历史数据得到各分项产量与其影响因素之间的定量关联关系，并引入气田开发动态指标新的预测方法(基于模糊综合评判的组合预测方法、神经网络优选组合预测模型预测方法以及基于遗传优化的神经网络预测方法)；(2)以数学规划为基础，结合数量经济学和技术经济学，引入经济指标建立产量分配优化模型、产量构成优化模型、措施产量构成优化模型、气田开发多目标规划模型以及五年规划模型，进而获得全气田及各采气厂的最优方案，并引入资金时间价值对五年规划模型进行改进；(3)以非线性规划问题的最优解及算法理论为基础，引入SUMT算法以及遗传算法对模型的求解进行研究，并在原有的遗传算法基础上，引入自适应调整方法对遗传算法进行改进；以算法的收敛性理论和计算复杂性理论为基础，逐一分析SUMT算法以及遗传算法的收敛性，并比较三种算法的优劣性。

In building the simulation models for manufacturing missions, based on the combination with the multi-agent method and the GOOPN method, the compoundable method is presented, which makes the models more intelligent. Based on the result above, combined with the GOOPN models and the GERTS model, we put forward EPN-GERTS model through embedding Petri net into GERTS model, which can simplify the complexity in building models, and also improve the defects of GERTS model in describing resource conflicts and Petri net model in building models. In building the simulation models for development missions, the improved GERTS model is present to describe the development processes in QRMS. Through dynamically computing the redo times in GERTS, the improved model can reflect the operation character of development process. The simulation results are more precise when we use the models above.

针对构建快速研制系统的仿真对象问题，提出了基于多Agent的快速研制系统可靠性复合仿真建模方法，增强了仿真模型的智能性；在此基础上，针对制造任务，将Petri网嵌入到GERTS网中，提出了用于快速研制系统制造任务可靠性仿真的EPN-GERTS模型，简化了建模过程，同时也能考虑任务之间的资源冲突；针对研制任务，提出了用于快速研制系统研制任务可靠性仿真的改进GERTS模型，该模型可以描述设计迭代过程的动态运行特点，使仿真结果更加准确。

Based on rail/wheel reaction and track/bride reaction theory and systems engineering theory, new vehicle-track and vehicle-track-bridge system dynamic models are established and discussed in details, including ballast track model and ballastless track model. The characteristics of the models are:(1) vehicle-track and vehicle-track-bridge system dynamic models are coupled in vertical and lateral;(2) track vibration on bridge is taken in account, track on bridge is considered as one or two layer continuous-point supported rail model, according to actual track structure, interaction between vehicle and bridge transfer from track structure;(3) three type of ballastless track models (tieembanked, elastic-tie-block, slab track) are presented;(4) models reflect the main feature of actual vehicle, track and bridge structure, the response computation frequency of models is relatively broad, which can be applied to analyze both low frequency and high frequency vibration.

基于轮轨相互作用和线桥相互作用特点，本文从系统工程角度出发建立了车辆、有碴轨道和无碴轨道、简支箱梁桥垂向和横向耦合系统动力分析模型，该系统模型具有以下特点：（1）车线、车线桥体系均考虑为垂向、横向耦合振动系统，车线间通过轮轨接触几何关系耦合，轨道与桥梁间通过轨道与梁体间的力与位移协调条件耦合；（2）充分考虑桥上线路在车线桥系统中参振作用，根据桥上线路轨道结构特点将桥上轨道结构模型具体化，即对桥上轨道结构视为多层支承体系，车桥间的动力作用通过轨道结构来传递；（3）建立了三种形式无碴轨道动力分析模型，即长轨枕埋入式、弹性支承块式和轨道板式无碴轨道模型；（4）系统模型详细，分析频带宽，适用范围较广。

Growth models of virtual trees include morphological structural models, functional models and functional-structural models. Functional-structural models may simulate the interaction between trees and its environment, whose outputs are 3D structure of trees. Therefore, functional-structural models are more close to realistic tree growth process and lead the trend of tree growth modelling.

虚拟树木生长模型包括形态结构模型、功能模型和结构－功能模型等，其中结构－功能模型可以模拟树木与环境间的相互关系，其结果为树木的三维结构，因此它最为接近现实树木的生长，是虚拟树木生长模型的发展方向。

What are your goals and strategies for growth?

你的成长目标和策略是什么？

And unto the angel of the church in Sardis write; These things saith he that hath the seven irits of God, and the seven star I know thy works, that thou hast a name that thou livest, and art dead.

3：1 你要写信给撒狄教会的使者，说，那有神的七灵和七星的，说，我知道你的行为，按名你是活的，其实是死的。