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Our results indicated that (1)SO_2 derivatives could dose-dependently relax the isolated aorta rings with or without endothelium precontracted by NE, no difference was found for the rings with and without endothelium;(2)Levels of cAMP and 6-Keto(PGI_2) in isolated aortic rings were increased by SO_2 derivatives in a dose-dependent way, which were independent of endothelium;(3)SO_2 derivatives decreased cGMP levels in the rings, but not significantly; The decrease of cGMP levels was also independent of endothelium;(4)No changes of TXB_2 in rings with or without endothelium were observed;(5)Whether presence or absence of endothelium, cAMP/cGMP and 6-Keto/TXB_2 ratios were increased significantly.

结果：①SO_2衍生物对去甲肾上腺素预收缩的内皮完整和去除内皮的大鼠胸主动脉血管环均呈浓度依赖性舒张作用，且其张力变化在内皮完整与去内皮的血管环之间无显著性差异；②SO_2衍生物可引起血管组织中cAMP、6-Keto(即PGI_2)含量剂量依赖性增加，其增加程度与内皮无关；③SO_2衍生物对血管环cGMP含量呈降低趋势但在统计学上无显著意义，且对去除内皮血管无显著影响；④SO_2衍生物对去内皮或内皮完整血管环的TXB_2含量均无明显影响；⑤无论是否去除内皮，SO_2衍生物均可引起cAMP／cGMP和6-Keto／TXB_2比值显著升高。

Dose-response indicated that the adults were more attracted when the dose of mango pulps was increased.

剂量反应结果表明，随着测试剂量的增加，芒果果肉挥发物对桔小实蝇成虫的引诱作用增强。

It seems to be a safe and effective combination. After one month the low-dose aspirin can be reinstituted and after one week the standard dose clopidogrel (75 mg) can be used.

这看似一种安全有效的联合。1个月后则重新应用小剂量阿司匹林，以及1周后应用标准剂量的氯吡格雷（75 mg/d）。

Should this modest increase in dose not be sufficient to alleviate symptoms, we double the prednisone dose. The disease flare is allowed to subside and the taper is reinstituted at a slower rate or at smaller decrements (eg, one-half of the original decrement). There are, to our knowledge, no data supporting one method or another.

如果这种剂量适度增加不足以缓解症状，我们则把强的松剂量加倍，当疾病复发平息后，再重新开始缓慢减量（如每月1次）或减量少一些（如原来减少量的1/2），据我们的了解，尚无支持一种或另一种方法的资料。

The different doses of 7603 and8102(100,400 and 1000mg/kg,which are eqivalent to 10,40 and 100times of the prescribed human dose)were given to ICR mice on the 7—11days of gestation.In the number of resorbed fetuses,the number of livefetuses,fetal weight and congenital malformations there were no signifi-cant difference between the control mice and the mice recieved variousdoses of 7603,or 8102,except the dose of...

结果可见，从7603各剂量组和8102的100、400毫克/公斤剂量组未观察到药物对孕鼠体重增长、活胎率、吸收胎率、胎鼠体重和胎鼠畸形发生率的影响。8102 1000毫克/公斤组则由于药物的毒副作用产生活胎率下降，吸收胎率和骨骼畸形率增加，孕鼠体重增长缓慢。

Kg-1, excitation dose was 2 times of sensitizing dose. The reaction of each animal was observed after excitation.

kg-1，静脉注射激发量是致敏量的2倍，激发后详细观察记录每只动物的反应情况。

Really the only affective drug is niacin and it is hard to use because of the flushing but if one is patient and gradually up titrates the dose, getting up to a full therapeutic dose is possible.

事实上唯一有影响的药物是烟酸，但它使用起来比较困难，因为患者可能会发生潮红。但是如果患者通过逐渐加药还是可能把剂量调整至靶剂量的。

Methods: The animals were divided into four groups randomly, including sham operation group, model control group, small dose (30 mg/kg, iv.) and large dose of ammonium oxalate (60 mg/kg, iv.) group. After the operation, ammonium oxalate was administrated and the electroencephalogram (frequency, scope and duration of the epileptic discharge) were recorded, and the survival neurons at the areas of hippocampus CA1 and CA3 was counted.

32只大鼠随机均分为4组：假手术组、模型对照组、小剂量草酸铵实验组(30 mg/kg)和大剂量草酸铵实验组(60 mg/kg)，各组均记录脑电（痫样波频率、幅度及总持续时间），HE切片计数海马CA1、CA3区残存正常神经元。

The results summarized as follows:(1)The main pharmacokinetic parameters Tmax was about 2h, Cmax was 8.365, 7.519, 1.871, 6.485, 4.060μg/mL in blood, gill, kidney, liver, and muscle respectively, after oral administration at a dose of 30 mg/kg; while t1/2 were 8.180~23.249h. These showed that the NFLX absorption was rapid after oral administration of NFLX in Scophthalmus maximus, but the residence time in the fish was long.(2) T1/2 were 74.88~200.45h after oral administration at dose of 30 mg/kg for five consecutive days, which showed that the attenuation of NFLX in the fish body was slow and the residue concentration in the kidney was the highest.

另外，本文测定了大菱鲆成鱼体内NFLX的药物浓度，用MCP-KP药动学程序对所得的药物浓度-时间数据进行分析，结果表明：1单次混饲口灌(30 mg/kg体重日)NFLX，药物在大菱鲆体内的达峰时间为2h，血液、腮、肾脏、肝脏、肌肉达峰浓度分别为：8.365、7.519、1.871、6.485、4.060μg/mL，消除半衰期为8.180～23.249h，说明NFLX在大菱鲆体内吸收较迅速，但滞留时间较长。2连续五天混饲口灌(30 mg/kg体重日)NFLX，消除半衰期为74.88～200.45h，说明混饲口灌NFLX在大菱鲆体内消除缓慢，其中以肾脏中残留最显著。

Methods According to the 4×4 Latin Square design,lytic efficacy was assessed in UK dose[(10 000 U/ml,20 000 U/ml,30 000 U/ml or 40 000 U/ml)]and the timing of Uk infusion(2,4,8,16 h after blood sample taken)and UK lytic time(2,4,8,16 h after UK infusion)in vitro.15 rabbits were subjected to the intracerebral hematoma model for analysing the effect of 2 differents UK dose(10 000 U vs 30 000 U)on brain tissue around hematoma cavity.

目的 探讨尿激酶溶解血凝块的最佳用药剂量、用药时机及药物最佳作用时间，为临床一次性清除血肿提供实验依据。方法采用2个(4×4)拉丁方设计，分析UK剂量[(1万U/ml、2万U/ml、3万U/ml、4万U/ml)]、用药时机(抽血后2、4、8、16 h)和药物作用时间(加UK后2、4、8、16 h)对溶凝效果的影响。

They have quite a lot of work to do.

他们有许多工作要做。

Let us give you a more elaborate example of this process.

让我们给你这个过程的更多的详细例子。