查询词典 maximum dose

The highest dose of CERA showed the best effect in all groups,With a good dose-response pattern.

CERA以上这些作用以高剂量组效果最佳，呈明显的剂量效应关系。

Blood-cooling and blood flow-promoting drugs has the effect of prevention and treatment for the early radiation-induced lung injury, Middle-dose and high -doses group were better than small-dose, however theres no difference between them. Suggest that using the adequate doses of blood-cooling and blood flow-promoting drugs would not enhance the effects of prevention and cure for radiation-induced lung injury if the doses of drugs were aggrandized.

早期应用凉血活血方对放射性肺损伤有防治作用，大、中剂量组的防治效果明显好于小剂量组，但大、中剂量两组无差别，提示凉血活血方中剂量即为较理想有效剂量，剂量加倍而疗效并不增强。

Results: 1. The value of all experimental indexes decreased significantly after heat stress, and reached the lowest at the time 2-8 hours after heat stress. This indicates that the immunity of the mice is damaged to the largest extent at 2-8 hours after heat stress. 2. L-arginine supplementation with appropriate dose could remit the acute atrophying of thymus and spleen tissue caused by heat stress. 3. After L-arginine supplementation with appropriate dose, the lymphocyte proliferation, the level of concentration of IL-2 and * expression of IL-2R raised in the group with room temperature; in the heat stress group the level of three indexs decrease significantly. Furthermore, the decrease of the group given 1 .Smglg.bw L-arginine is the smallest. This result indicates that the concentration of 1 .Smglg.bw L-arginine supplementation could remit the depressment of the immunity caused by heat stress. 4. The [Ca2~] in activated thymocytes of the group with L-arginine -2- supplementation is significantly higher than that of the group with water supplementation. This indicates that L-arginine supplementation could protect thymoeytes of mouse under heat stress. We also found that the fluorescence intensity of [Ca2~] in activated thymocytes of the group given 1 .Smglg.bw L-arginine is the highest.

结果：1、热应激后小鼠的各项免疫指标均有显著性下降，其中在2.8小时降到最低，提示在这个时间段小鼠的免疫功能受到最大损害；2、适量补充精氨酸有助于缓解热应激导致小鼠胸腺和脾脏的急性萎缩；3、常温组，补充适量精氨酸后小鼠淋巴细胞增殖活性、IL-2的浓度及IL-2R的表达均有显著性上升，而热应激后三指标均显著降低，其中在精氨酸给予浓度为1.5mg/g.bw时三指标的降低程度最少，提示该浓度可最大程度缓解热应激对小鼠免疫功能的抑制；4、补充精氨酸组的活化胸腺细胞［Ca~(2+)］较给水组有显著性上升，说明精氨酸对热应激小鼠胸腺细胞具有保护作用，并发现在精氨酸给予浓度为1.5mg/g.bw时活化胸腺细胞的胞浆钙离子荧光强度达到最大；5、热应激后小鼠血清NO的浓度均有不同程度的上升，补充精氨酸后血清NO上升更加明显，但并非随精氨酸给予浓度的增加而增加。

In patients with acute PE, if IV UFH is chosen, we recommend that after an initial IV bolus (80 U/kg or 5,000 U), it is administered by continuous infusion (initially at dose of 18 U/kg/h or 1,300 U/h) with dose adjustment to achieve and maintain an APTT prolongation that corresponds to plasma heparin levels of 0.3 to 0.7 IU/mL anti-Xa activity by the amidolytic assay rather than administration as IV boluses throughout treatment, or administration without coagulation monitoring (Grade 1C).

急性PE患者，如果选择IV UFH，我们推荐初始快速注射80U/kg或者5000U，继之以18 U/kg/h 或 1，300 U/h持续静滴。根据APTT延长，或者监测血浆肝素水平在0.3'0.7IU/ml， amidolytic assay 分析抗Xa因子活性来调整UFH剂量，而不能持续静脉注射治疗，或者不监测凝血功能（1C）。

Methods Forty mice were randomly divided into 4 groups: one normal control group,mice in the other three groups were all infected each with 25 cercariae, the infected control group was fed for 10 weeks after infection, and 2 weeks after infection, the high dose PTX group was given PTX 360 mg/ for 8 weeks and the low dose PTX group was given PTX 180 mg/also for 8 weeks.

将40只小鼠随机分为4组，其中3组每只小鼠人工感染日本血吸虫尾蚴25条，1组感染后继续喂养10周，不作治疗，作为感染对照组；2组分别于感染后2周用PTX 360 mg/和180 mg/灌胃治疗8周；另1组不感染、也不接受药物治疗，与上述3组同步喂养10周，作为正常对照组。10周后将上述4组小鼠分别剖杀取肝组织，光镜观察肝组织病变；用免疫组化染色方法检测小鼠肝组织中Bcl-2、Bax的水平。

Results:weijian obviously shortened the latent period of erection in castrational rats after electric stimulus and the latent period of coitus in castrational mice,increased coitus times in castrational mice,increased the appearance rate of sperm suppository in copulated female mice. the acute toxicity tests showed that the half lethal dose(ld50) of weijian was 901.53 mg/kg and 319.60 mg/kg, the long-term toxicity tests showed that large dose of weijian slightly increased the level of glutamic pyruvic transaminase and decreased the glucose,triglyceride and cholesterol of blood, while had no effects on other biochemical factors.

结果： 伟剑能明显缩短去睾丸大鼠的电刺激阴茎勃起潜伏期，明显缩短去睾丸小鼠的性交潜伏期，并增加去睾丸小鼠的性交次数，增加交配后雌性小鼠的精栓出现率；急性毒性试验测得伟剑的口服半数致死量（ld50）为901.53 mg/kg，腹腔注射的ld50为319.60 mg/kg；长期毒性试验研究表明该药在大剂量时可轻度升高谷丙转氨酶，轻度降低血糖、总胆红素及胆固醇，而对其他血液生化指标无影响。

On the other hand, the intensity of ultrasound stated, percutem transit dose of drug could be increased along with the time at the range of 10 min to 30 min. However, if it was given ultrasound over 40min, percutem transit dose of drug would be reduced significantly. Therefore, it was supposed that skin temperature was increased during a long time of ultrasound, and the skin would be damnified.

超声强度一定时，超声时间由10分钟加长到30分钟时，药物的累积经皮渗透量增加，当超声时间增加到40分钟时，药物的经皮渗透量却明显减小，可能是由于超声时间加长后，使皮肤温度显著升高，对皮肤造成损伤所导致的结果。

Internal dose ones and external dose ones are concluded.(2) Biomarker of effect. It indicates those indicaters inflecting the biochemical, biophysical, behavioral, or else changes. Three types of biomarkers, early biological effect, altered structure / functon and disease, are comprised.

生物标志物是包括反映生物系统与环境中化学、物理或生物因素之间相互作用的任何测定指标，可将其分为三类：(1)接触的生物标志物，即反映机体生物材料中外源性物质或其代谢物或外源性物质与某些靶细胞或靶分子相互作用产物的含量，包括反映内剂量和生物效应剂量两类标志物；(2)效应的生物标志物，指机体中可测出的生化、生理、行为或其他改变的指标，包括反映早期生物效应、结构和功能改变(altered structure/functon)及疾病3类标志物；(3)易感性的生物标志物，即反映机体先天具有或后天获得的对接触外源性物质产生反应能力的指标。

Methods: A total of 21 young swines were randomly divided into untreated group, low-dose salvianolate group and high-dose salvianolate group (7 in each group). AMI was induced by ligaturing left anterior descending coronary artery. After the operation, 400 or 200 mg salvianolate dissolved in 250 mL 5% glucose saline was administered by intravenous drip to swines in the HS group and the LS group respectively for 7 days. The swines in the untreated group were administered with 250 mL 5% glucose saline.

苏中幼猪21只，随机分为模型组和低、高剂量丹参多酚酸盐组。3组均经开胸结扎冠状动脉左前降支制作心肌梗死模型，造模成功后当日，高剂量丹参多酚酸盐组给予400mg丹参多酚酸盐加250mL 5%写葡萄糖生理盐水静脉滴注；低剂量丹参多酚酸盐组给予200mg丹参多酚酸盐加250mL 5%葡萄糖生理盐水静脉滴注；模型组给予等体积的5%葡萄糖生理盐水静脉滴注。1次／d，连续给药7d。

Through reforming original dose calculation models established for regular irradiation field, we present a set of more efficient and systematical solution to calculate dose distribution of regular irradiation field.

我们在对原有规则野剂量计算模型和算法中存在的各种缺陷进行改进和有机合成的基础上，提出了一整套规则野剂量计算的更优解决方案。

They have quite a lot of work to do.

他们有许多工作要做。

Let us give you a more elaborate example of this process.

让我们给你这个过程的更多的详细例子。