查询词典 maximum dose

Under inverted microscope, stereognosis of neurons died down, there were blank bulb in the neurons, dark particle were seen in the neuritis; the result of MTT test showed that the survival rate of neurons was obviously decreased. Res 40μmol/L increased the survival rate of neurons. Aβ(subscript 25~35) dose-dependently increased the level of MDA, decreased the level of GSH. Res dose-dependently increased the level of GSH, decreased the level of MDA.

结果：Aβ(下标 25~35)在终浓度为2μmol/L时神经元形态有明显的变化，细胞立体感减弱，胞体内空泡形成，细胞突起内可见黑色颗粒状物；细胞的存活能力明显下降，与对照组相比较有显著性差异(P.05)；Res在终浓度40μmol/L时，能明显提高细胞的存活能力。Aβ(下标 25~35)可以明显升高细胞培养上清液中MDA含量，降低GSH的含量；Res可使细胞培养上清液中MDA含量下降，GSH含量增加。

Intravenous medium and high erythromycin and azithromycin dose had obvious exciting effect on spontaneous afferent nerve discharge (erythromycin: 8.34 ± 0.37, 8.54 ± 0.26 vs 7.78 ± 0.23, 7.84 ± 8.27; azithromycin: 8.57 ± 0.43, 8.28 ± 0.38 vs 7.74 ± 0.21, 7.86 ± 0.30) and gastric distention-induced afferent nerve discharge of subdiaphragmatic vagus nerve (erythromycin: 8.54 ± 0.34, 8.61 ± 0.20 vs 8.13 ± 0.36, 8.19 ± 0.21; azithromycin: 8.54 ± 0.30, 8.42 ± 0.21 vs 8.24 ± 0.22, 8.22 ± 0.19), which was statistically significant compared with the control and low dose groups.

结果： 静脉注射小剂量红霉素和阿齐霉素自发放电和对扩胃诱发放电均无显著变化， 20 min后中、大剂量红霉素和阿齐霉素注药后自发放电(红霉素： 8.34±0.37， 8.54±0.26 vs 7.78±0.23， 7.84±8.27；阿齐霉素： 8.57±0.43， 8.28±0.38 vs 7.74±0.21， 7.86±0.30)和对扩胃诱发放电均增强(红霉素： 8.54±0.34， 8.61±0.20 vs 8.13±0.36， 8.19±0.21；阿齐霉素： 8.54±0.30， 8.42±0.21 vs 8.24±0.22， 8.22±0.19)与相应的对照组和小剂量组间差异有统计学意义。

Coadministration of a subeffective dose of L-NNA (3 pmol) or ODQ (10 nmol) with morphine prevented its antiedematogenic effect, but sildenafil (0.15 nmol) rendered a subeffective dose of morphine effective (18 nmol).

亚效应剂量 L-精氨酸(3 pmol)或 ODQ(10 nmol)与吗啡同时注射则会抑制后者的抗水肿作用。

Methods After taking triazolam and distilled water respectively, the mice sleeping-behavior state was observed and recorded; the ratio of sleeping mice was recorded after taking different of ingredients Eucommia ulmoides Oliv. combining with pentobarbital sodium at subliminal dose, and mice latent period and sleeping time at supraliminal dose. Measure the content of interleukin-1β(IL-1β) in mice brain with enzyme-linked immunosorbent assay, weigh spleen and thymus of mice.

通过观察记录日间小鼠睡眠行为状态，戊巴比妥钠阈下催眠剂量实验，延长戊巴比妥钠睡眠时间实验，酶联免疫吸附反应分别检测服用3种不同极性的提取部位、阳性对照物和空白对照组的小鼠脑组织中IL-1β含量，并结合脏器指数等综合分析。

Results At the dosage of 25 mg/kg,AN could induce higher incidence of fetal resorption and death,and decrease the average fetal body weight and le ngth with significant difference(P＜0.05)when compared with neg ative controls.At the dosage of 35 mg/kg,AN could decrease average vital fet us p er litter with significant difference(P＜0.05),and induce chang es of other indexes with highly significant difference(P＜0.0 1).At the dosage of 25 and 35 mg/kg,AN could induce higher teras rate,maternal t eras rate and malformation rate of vital fetus with significant and/or highly s ignificant difference(P＜0.05 or P＜0.01),resp ectively.There existed a dose-effect or dose-response relationship between abo ve indexes and doses.

结果 25 mg·kg-1组死胎率、吸收胎率升高，胎鼠平均体重、体长、尾长减小，与阴性对照组比较差异有显著性(P＜0.05)；35 mg·kg-1组除窝平均活胎数减少，差异有显著性( P＜0.05)，其余各指标与阴性对照组比较差异有非常显著性(P ＜0.01)；25，35 mg·kg-1组畸胎率、母体畸胎率、活胎畸形率升高，与对照组相比差异有显著性和/或非常显著性(P＜0.05或P ＜0.01)，且有明确的剂量效应或剂量反应关系。

On September 6, 2005, the US Food and Drug Administration licensed the combination tetravalent MMRV vaccine for use in children aged 12 months to 12 years. To prevent measles, mumps, rubella, and varicella, MMRV vaccine can be used instead of trivalent MMR vaccine and monovalent varicella vaccine. To fulfill the recommended 2-dose vaccine policies, the first dose is recommended at age 12 to 15 months and the second at age 4 to 6 years.

2005年9月6日，美国食品药物管理局核准四合一的MMRV混合疫苗用於12个月至12岁的小孩；为了预防麻疹、腮腺炎、德国麻疹、水痘，MMRV疫苗用於取代三合一的MMR治疗加上水痘疫苗；为了符合建议施打两次的疫苗政策，第一剂建议在12至15个月大，第二剂在4至6岁。

On September 6, 2005, the US Food and Drug Administration licensed the combination tetravalent MMRV vaccine for use in children aged 12 months to 12 years. To prevent measles, mumps, rubella, and varicella, MMRV vaccine can be used instead of trivalent MMR vaccine and monovalent varicella vaccine. To fulfill the recommended 2-dose vaccine policies, the first dose is recommended at age 12 to 15 months and the second at age 4 to 6 years.

2005年9月6日，美国食品药物管理局核准四合一的MMRV混合疫苗用于12个月至12岁的小孩；为了预防麻疹、腮腺炎、德国麻疹、水痘，MMRV疫苗用于取代三合一的MMR治疗加上水痘疫苗；为了符合建议施打两次的疫苗政策，第一剂建议在12至15个月大，第二剂在4至6岁。

The results of surface dose rate determined with lithium fluoride thermoluminescent dosimeter chips in water-organic glass phantom and air had no obvious difference and the surface dose rate and its uniformity,(3.46±0.011) and (0.178±0.15)nGy/h*107Bq were obtained.

用LiF热释光片在水-有机玻璃体模及空气中，分别作125I眼科巩膜敷贴器的表面剂量测定，结果在误差范围内无明显区别，得到的最终表面剂量及其均匀性分别为：(3.46±0.01)、(0.178±0.15)nGy/h*Bq。

Since a recent randomized study showed no dose-response relationship, the target dose in future will be 20mg tid.

由于最近一项研究显示无量-效关系，所以将来的剂量可能是20毫克日三次。

objective to investigate the existence of the erythropoiesis inhibitors.methods the present study included twelve undialyzed esrd patients with anemia.the sera from the uremic patients were added to cfu-e and bfu-e culture in the concentrations ranging from 1.25% to 5%.in vitro cfu-e and bfu-e growth in the presence of sera from esrd patients was compared with in the presence normal human subjects with the use of normal mice bone marrows.results the effects of the sera from uremic patients on cfu-e and bfu-e colony growth in concentrations ranging from 1.25% to 5% were investigated to be dose-dependent.the effect increased with the concentrations increasing of the sera（p＜0.05）.there were not significant inhibitory effect on the cfu-e and bfu-e growth of mice bone marrow in vitro from sera of the normal subjects.conclusion the erythropoiesis inhibitors exist in uremic sera which has a dose-dependent inhibitive effects on the growth cfu-e and bfu-e of normal mice bone marrow cells.

选择12例尿毒症肾性贫血未透析患者为试验组，另选正常健康体检者12例为正常对照组，将实验组、正常对照组血清分别稀释成不同终浓度，采用甲基纤维素细胞培养的方法对小鼠骨髓细胞进行培养，对比不同浓度血清组红系集落形成单位、红系爆式形成单位的集落数。结果在实验组中，与血清浓度为0的浓度组相比，与各浓度组血清共同培养的小鼠骨髓cfu-e和bfu-e的集落数均明显减少，且随血清浓度的增加，小鼠骨髓cfu-e和bfu-e的集落数逐渐减少，各浓度组间差异有显著性（p＜0.05）。结论尿毒症患者血清抑制小鼠骨髓红系祖细胞集落形成，随患者血清浓度的增加，抑制作用增强，具有剂量依赖性。

He tendered his resignation to the Prime Minister.

他向首相递了辞呈。不适合

International economy and trade,Nanking 210044

国际经济与贸易，南京 210044