查询词典 lethal dose

The conventional dose, 3 times the dose kelp and Prunella are caused by iodine deficiency in rats hyperthyroidism, conventional doses of kelp with the dose increased the degree of severe hyperthyroidism, Prunella laminarin compared with hyperthyroidism minor.

常规剂量、3倍剂量昆布和夏枯草均致碘缺乏大鼠甲状腺功能亢进，常规剂量昆布随着剂量增加甲亢程度严重，夏枯草与昆布相比甲亢程度轻微。

The method uses tall fat emulsion to build bandicoot tall lipemia model of sexual fatty liver, experimental cent is group of high dose of drink of fat of regular set, model group, disappear and small dose group, treasure liver peaceful is electropositive group to the south of, with drink of fat of disappear of tall, small dose peaceful of He Dongbao liver undertakes intervention, determine branch content exceeds to cross oxide in liver fat content and liver enzymatic active, third 2 aldehyde content and vitamin E level.

方法采用高脂乳剂建立大鼠高脂血症性脂肪肝模型，实验分为正常组、模型组、消脂饮高剂量组和低剂量组，以东宝肝泰为阳性组，以高、低剂量消脂饮和东宝肝泰进行干预，测定肝脂含量及肝中超歧物过氧化物酶活性、丙二醛含量和维生素E水平。

In order to observe the effects of mercuric chloride to physiological and biochemical indexes of blood at low doses in SD rats, 24 SD rats were separated into control group, low dose group of mercury (50 mg/L), middle dose group of mercury (100 mg/L), high dose group of mercury (200 mg/L), which were given in the drinking water.

为了研究低剂量汞对SD大鼠血液生理生化指标的影响，24只SD大鼠被随机分为4组，分别为对照组，汞低剂量组（50 mg/L），汞中剂量组（100 mg/L），汞高剂量组（200 mg/L），采用自由饮水染毒，染毒时间为21d。

Results ①Compared to sham group, ISH and IHC of rat hypothalamic CRHshow positive cells numbers increase, positive areas enlarge and average gray scaledecreases, which reveals the expression of hypothalamic CRH neurons enhances afterPX;②The enhancement of ISH and IHC of hypothalamic CRH in PX rats aftermelatonin supplementation dose-dependently recovers, but it can't return to be normaleither in high dose group or in low dose group and either at 4th week or at 8th week;③IHC of CRH in median eminence of neurohypophysis shows positive areas enlargeand average gray scale decreases, which reveals the releasing of CRH fromhypothalamic CRH neurons increases;④ELISA of CRH in serum shows thedifferences of CRH concentrations among all groups are not significant, which indicates PX and melatonin supplementation have no significant effect on CRH levels.

结果： ①松果体摘除后大鼠下丘脑室旁核CRH 原位杂交和免疫组化的结果与假手术对照组相比均显示阳性细胞数增多、阳性面积增加、平均灰度降低，提示松果体摘除后下丘脑CRH 神经元的表达增强；②松果体摘除大鼠补充褪黑素后，下丘脑CRH 原位杂交和免疫组化染色增强呈剂量依赖性恢复，不过不论是低剂量组还是高剂量组，也不论是术后4 周还是术后8周，均不能恢复至正常；③松果体摘除后神经垂体正中隆起CRH 免疫组化结果显示阳性面积增加、平均灰度降低，提示下丘脑CRH 神经元释放CRH 增加；④ELISA 法检测血清CRH结果示各组血清CRH 浓度差异没有显著性，表明松果体摘除及补充褪黑素对血清CRH 水平没有显著影响。

Results ①Compared to sham group, ISH and IHC of rat hypothalamic CRHshow positive cells numbers increase, positive areas enlarge and average gray scaledecreases, which reveals the expression of hypothalamic CRH neurons enhances afterPX;②The enhancement of ISH and IHC of hypothalamic CRH in PX rats aftermelatonin supplementation dose-dependently recovers, but it can't return to be normaleither in high dose group or in low dose group and either at 4th week or at 8th week;③IHC of CRH in median eminence of neurohypophysis shows positive areas enlargeand average gray scale decreases, which reveals the releasing of CRH fromhypothalamic CRH neurons increases;④ELISA of CRH in serum shows thedifferences of CRH concentrations among all groups are not significant, whichindicates PX and melatonin supplementation have no significant effect on CRH levels.

结果： ①松果体摘除后大鼠下丘脑室旁核CRH 原位杂交和免疫组化的结果与假手术对照组相比均显示阳性细胞数增多、阳性面积增加、平均灰度降低，提示松果体摘除后下丘脑CRH 神经元的表达增强；②松果体摘除大鼠补充褪黑素后，下丘脑CRH 原位杂交和免疫组化染色增强呈剂量依赖性恢复，不过不论是低剂量组还是高剂量组，也不论是术后4 周还是术后8周，均不能恢复至正常；③松果体摘除后神经垂体正中隆起CRH 免疫组化结果显示阳性面积增加、平均灰度降低，提示下丘脑CRH 神经元释放CRH 增加；④ELISA 法检测血清CRH结果示各组血清CRH 浓度差异没有显著性，表明松果体摘除及补充褪黑素对血清CRH 水平没有显著影响。

Accuracy between two groups was calculated byχ~2 test.Calculate the average effective radiation dose of the 30 patients.Results In group A,seventeen patients underwent both DSCT coronary angiography and SCAG,among 255 segments of 17 patients,105 lesion sites of 70 segments were diagnosed stenosis or obstruction,of them,95 lesion sites were confirmed by SCAG.The accuracy of DSCTCA was 90.48%.The agreement of two methods have a high agreement(Kappa =0.853).In group B,13 patients underwent both DSCT coronary angiography and SCAG,among 195 segments of 13 patients,73 lesion sites of 57 segments were diagnosed stenosis or obstruction, of them,65 lesion sites were confirmed by SCAG.The accuracy of DSCTCA was 89.04%.The agreement of two methods have a high agreement(Kappa =0.835). There was no significant difference(χ~2=0.098,p＞0.05) between the accuracy of two groups.The effective radiation dose of 30 patients was 3.67±0.43 mSv.Conclusion Compared with SCAG,prospectively ECG-gated transverse DSCT is a valuable examination to detect and diagnose coronary artery disease with a low dose coronary angiography.The accuracy of the DSCT is approximate to the SCAG.There was no significant difference between the accuracy of two groups.

结果200例患者均成功完成了适应性前瞻性心电门控双源CT冠状动脉血管成像；30例同期行SCAG检查的患者，A组17例：HR≤75 bpm，可评价冠状动脉节段255个，70个冠状动脉节段有105处不同程度的狭窄，95处狭窄程度与金标准SCAG相符，其阳性诊断准确率为90.48%；2种方法的诊断结果得到了较高的一致性(Kappa值=0.853)。B组13例；HR≥91 bpm，可评价冠状动脉节段195个，57个冠状动脉节段有73处不同程度的狭窄，65处狭窄程度与SCAG相符，其阳性诊断准确率为89.04%；2种方法的诊断结果得到了较高的一致性(Kappa值=0.835)。2个心率组间的诊断准确率无明显统计学差异(x~2=0.098，p＞0.05)。30例患者的平均有效辐射剂量为3.67±0.43 mSv结论适应性前瞻性心电门控双源CT冠状动脉成像是一种有效减低辐射剂量的扫描方式，其诊断准确率与金标准SCAG相比得到较高的一致性，且高、低2个心率组间诊断准确率无明显统计学差异。

The results showed that the population administered with free adjuvant cholera vaccines,both low dose group and common dose group,occurred the weak adverse reaction with 10￣25% rate.The reaction rates between two dose groups of the same vaccine have not significant difference;The reaction rate of the first inoculation(19￣25%) is higher than those of the second inoculation(10￣15%)(P 05);The inoculating local reaction is very light ,only the very few subject occurred the scleroma with 15 mm of diameter.The reaction of aluminum absorbed cholera vaccine is slightly stronger than those of other groups.

结果表明，不加铝佐剂的O139型霍乱菌苗及O1群霍乱菌苗，不论是低剂量组（两剂全程接种45亿菌体）抑或常剂量组（全程接种90亿）接种人群均可产生10～25％的体温呈轻度升高的弱反应，并且同种菌苗的两剂量组的反应率无显著差异；第一剂接种的反应率（19～25％）较第二剂接种的（10～15％）高，P＜0.05；接种局部反应轻微，只有个别受试者出现直径小于15mm的硬结；加佐剂的O1群吸附霍乱菌苗的反应较其它组强。

Methods:Establish the model of myocardial fibrosis in chronic stage of viral myocarditis by injecting CVB3 into Balb/c rats,divide these rats into model group、Tong xin luo low dose group、Tong xin luo medium dose group、Tong xin luo high dose group and set up normal group,after four weeks of giving medicine execute the animals and observe the ultrastructure of myocardial cell with tramission electron microscope,the quantity of myocardial collagen was observed by staining with H.E and Sirus red in supersaturated picric acid solution;the amount of HA in serum was measured with the method of radiative immunity;the quantitative expression of fibrosis factor—TGF、PDGF was measured with the method of immunity histochemistry.

腹腔注射柯萨奇B3病毒建立病毒性心肌炎慢性期心肌纤维化小鼠模型，随机分为模型对照组、通心络低剂量组、中剂量组、高剂量组，并设正常对照组，用药四周后处死动物通过透射电镜观察心肌细胞超微结构；HE染色、苦味酸天狼星红染色观察心肌胶原数量；放免法测定血清透明质酸的含量；免疫组化染色观察致纤维化细胞因子—转化生长因子和血小板衍生生长因子的定量表达。

The radiotherapeutic dose over the whole pelvis was 30Gy to 36Gy by Co 60 unit or 15Mev. Linear Accelerator and further teletherapy with changed portal or brachytherapy of high dose rate (Co 60) followed according to location and size of the recurrence. The total vaginal one-centimeter submucosal dose was 75-80Gy.

治疗方法以放射线治疗为主：使用钴60或15MV光子射线先照射全骨盆腔30至36Gy的剂量；然后再按病灶部位及范围，或改变照野方向和大小继续作远隔治疗，或采用高剂量率腔内近接治疗，使阴道粕膜下1公分处总共接受75至80格雷的剂量。

If you start very rapidly with high dose you will have flatulence just as if you were to take a high fiber diet but if you start very slowly and low dose and titrate very slowly then you will avoid most of the dose symptoms.

如果您以高剂量快速开始，您会有如同摄入高纤维饮食似的肠胃气胀；但是，如果您以低剂量缓慢开始，并且缓慢滴定，您将可避免绝大多数剂量依赖性症状。

The statistical analysis of this large set of mutations has led us to propose a diagnostic strategy that should help with the molecular work-up of optic neuropathies.

这一大系列基因突变的统计学分析引导我们提出一个诊断策略，可以帮助我们对视神经病变进行分子学的诊断检查。

The results show that the pipe grouting changes the mechanical parameters of surrounding rocks to achieve the security of engineering objectives by reinforcing surrounding rocks and bolcking the water.

研究表明：小导管注浆一方面改变了围岩的力学参数，另一方面利用浆液的固结特性可以实现堵水和加固围岩的工程目标，使隧道在开挖过程中的安全得到保障。