查询词典 coherently oriented simplex

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Improve the simplex algorithm, the class definition and implementation, higher efficiency, single-parameter optimization of the initial param...

改进的单纯形算法，类的定义及实现，效率较高，单参数优化对初始参数要求不高。

Objective: To investigate the effect of protecting liver of brevifolin and 8,9-single-epoxy brevifolin of Phyllanthus simplex .

中文摘要：目的：探讨黄珠子草有效成分短叶苏木酚及8，9-单环氧短叶苏木酚保肝作用及机制。

It is indicated that the water extract of Phyllanthus simplex Retz.

提示台湾细叶油柑水提取物有抗乙肝病毒作用。

Thus, in polyarthritic rat, a model of chronic inflammatory pain, we demonstrated that herpes simplex irus ector mediated oerexpression of proenkephalin A in primary sensory neurons at the lumbar leel elicited both antihyperalgesic and anti-inflammatory actiities.

在一个慢性炎症性疼痛模型－多关节炎鼠上，我们证明单纯疱疹病毒媒介介导的前脑啡肽在腰水平初级神经原的过度表达引起了抗痛觉高敏和抗炎症活动。

OBJECTIE To ealuate the effect of herbal eye drop of Reduqing and potentialization of ultrasonic nebulous adiministration of Reduqing on experimental herpes simplex keratitis in rabbits, the acute toxicity test and the irritating eye reaction.

目的 评估中药热毒清滴眼液对兔实验性单纯疱疹性角膜炎(herpessimplexkeratitis ，HSK)作用和超声雾化强化给药的疗效及急性毒性与眼的刺激反应。

The early Breeze, Fisher, and Ritchey mountain bikes used an eclectic mixture of components: Huret Duopar or SunTour VGT rear derailleurs, Simplex front derailleurs, SunTour Power thumb shifters, Magura motorcycle brake levers, and Mafac cantilever brakes.

早期的微风，费希尔和里奇山地自行车，使用了一个折衷的混合物组成部分：呼热图Duopar或山图变截面后方derailleurs，单纯前derailleurs，拇指山图电源转换器，马古拉摩托车制动杠杆，玛法科悬臂式制动系统。

All the LOH on 〓 and 〓 was observed in invasive ductal carcino- ma, carcinoma simplex, medulary carcinoma and scirrhous carcino- ma, no deletions at these sites were observed in any invasive lobular carcinoma and others. These results imply an etiological difference.P53 gene is a hot point gene in the occurrence and development of breast, cancer. PCR-SSCP analysis was performed to detect P53 gene point mutation in the region between exon 5 and 8, 5 of 12 (41. 6%) stage I breast cancer patients contain mutation of P53, 3 of 5 patients were accompanied by 〓 deletion. These results suggested that point mutation and allelic loss of P53 gene are two vi- tal genetic events in earlier stage of breast tumorigenesis.

我们还发现，〓和〓位点LOH均分布在乳腺浸润性导管癌、单纯癌、髓样癌及硬癌中，在浸润性小叶癌和某些特殊类型乳腺癌中全部为LOH阴性，上述位点LOH可能与某些组织学类型乳腺癌的发生有关。P53基因是乳腺癌形成过程中的一个热点基因，本研究对12例Ⅰ期乳腺癌组织标本中P53基因热点区域第5、6、7、8外显子点突变进行了测定，发现41.6％（5／12）的病人有P53基因一个或多个点突变，其中3例同时伴有〓位点LOH，表明P53基因点突变和等位基因缺失是发生在乳腺癌形成早期的一个重要遗传学事件。

Methods PCR was used to detect herpes simplex virus type 1(HSV-1)DNA in 33 eyes with active HSK,5 eyes with serpiginous corneal ulcer and 5 eyes with keratitis with unknown cause.

应用PCR技术对临床诊断活动期HSK 33眼匐行性角膜溃疡5眼，原因不明角膜炎5眼进行HSV-1 DNA检测。

The paper studied the improved process for preparing phosphorus sulfochloride, where high-effective liquid catalyst was employed, and investigated the catalytic activity and service life of the novel catalyst. The optimum process conditions of batch and semi-continous operation were obtained by single factor experiments and modified simplex experiments.

本论文研究了采用高效液相催化剂制备三氯硫磷的新工艺，对催化剂寿命和性能进行了考察，利用单因子实验和改进单纯形实验找到了间歇操作和半连续操作的最佳工艺条件。

"Second Life is remarkably easy to work with, and is very popular,"

"第二次生命是显着容易的工作，并且很受欢迎，"

For example, we usually assume that materials are homogeneous and isotropic and free of internal defects or flaws.

为了得到适合有限元分析的模型，我们必须经过如图2所示的简化步骤。