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Pinl is a unique peptidyl-prolyl cis/trans isomerases and can specifically isomerize the phosphorylated Ser/Thr-Pro bonds in certain proteins, thereby modulating their functions.

肤基脯氨酞顺反异构酶Pinl，是由酵母双杂交筛选出的一种功能蛋白，主要调节有丝分裂相关蛋白酶，对细胞周期运行起着非常重要的调节作用赶'〕。

Application Ser. No. 10/804,314, entitled "Optical System for Light Emitting Diodes" by Matthijs H. Keuper et al., filed Mar. 19, 2004, which has the same assignee as the present application and is incorporated herein in its entirety.

Keuper等人的名称为&用于发光二极管的光学系统&的美国申请第10／804，314号中所公开的配置，该申请具有与本申请相同的受让人并且以其全文引用的方式结合在本文中。

Through their ubiquitin E3 ligase activities c-IAP1 and c-IAP2 promote proteasomal degradation of NIK, the central ser/thr kinase in the noncanonical NF-κB pathway.

在泛素化的过程中，E3连接酶激活c-IAP1，同时c-IAP2促进NIK蛋白体降解，NIK是非经典NF-kB途径中的核心，有丝/苏氨酸激酶的活性。

Second, residues in the reactive site of the inhibitor were replaced by the consensus substrate recognition sequence of furin, namely, Arg at P_1, Lys at P_2, Arg at P_4 and Arg at P_6. In addition, the P_7 residue Asp was substituted with Ala to avoid possible electrostatic interference with furin inhibition. Finally, the extra N and C terminal residues beyond the doubly conjugated disulfide loops were further truncated. However, all resultant synthetic peptides were found to be temporary inhibitors of furin and kexin during a prolonged incubation, with the scissile peptide bond between P1 and P'1 cleaved to different extents by the enzymes.

高活性、低分子量的furin酶抑制剂有可能发展成为新型的抗细菌内毒素和抗病毒感染的药物，我们以绿豆胰蛋白酶抑制剂Lys片段长链22肽为模板，设计了一系列能抑制furin和kexin活性的突变体，采用如下三种方法逐步优化：一、去除Lys片段长链三对二硫键中的一对，用Ser替换Cys，减少可能存在的二硫键错误配对；二、抑制剂的活性中心根据furin底物的专一性逐步改变，即P1、P2、P4和P6位分别变为Arg、Lys、Arg和Arg，同时为了避免P7 Asp和P6 Arg之间可能存在的相互作用，将P7位Asp替换为Ala；三、将两对二硫键形成的双环的外面5个氨基酸残基去除。

As a professional manufacturer from 1971, we supply a wide range of under wears including shole ser bras and panties.

自1971年起，我们即开始生产各类内衣，胸罩及内裤，是专业的绩优厂商。

Three expression vectors containing mutant gfp which were truncated from 3′ termine were constructed in the present paper.The mutation gfp with different length under the control by T 7 promoter were expressed in E. coli BL21 cells.

本文将突变型 gfp3′末端不同程度地截短，构建成表达载体，在大肠杆菌 BL 2 1中表达了不同长度的绿色荧光蛋白，当其生色基因中 65位 Ser点突变成 Thr，则 GFP的激发波由 396nm增至 4 70 nm，不用 UV激发，仅在自然光源下就可看到强烈的绿色荧光，发光强度增加 6倍，若从 3′端截短 12个氨基酸密码，对发光无影响，但截短 75个氨基酸密码，则激发波长降到 360 nm，发光强度减少 12倍。

As we show in detail in Figure 29.31, the result of Wnt signalling is to increase the level of -catenin, which causes it to translocate to the nucleus.

Ras固定在细胞膜里面向细胞质的一侧，以活化的Ras与Ser/Thr激酶Raf结合，因而将Raf带到质膜，使得Raf被激活。

In cells treated with sublethal doses of UVordoxorubicin,Pirh2 abrogates Axin-induced p53 phosphorylation at Ser-46 catalyzedby HIPK2,through competing against HIPK2 binding to Axin.

在亚致死剂量的紫外辐射或是柔红霉素的处理下，Pirh2通过竞争HIPK2与Axin的结合而阻碍Axin介导的由HIPK2催化的p53的46位氨基酸的磷酸化。

Iraq took delivery of its first 18 "Fulcrums" in 1987, the year before the Iran-Iraq War ended, so it's possible that some Iraqi MiG-29s saw limited ser- vice in the war, but given the time necessary to train pilots and ground crew, and make new aircraft operational, it's likely that the war ended before the MiGs saw any serious fighting.

伊拉克是在1987年最初的18&支点交付&，一年前的两伊战争结束后，因此它可能是一些伊拉克米格-29看到有限的丝氨酸在战争中副，但由于时间所必须培养飞行员和地勤人员，并作出新的飞机作战，很可能是在战争结束之前，米格看到任何严重的战斗。

Filipa: Filipa : Será que me podia arranjar a product key do "Microsoft Office Home and Student" o mais...

色拉寺你我arranjar平台的产品主要做&微软Office家庭和学生&啊，看。。。

Chrysanthemum of 10 thousand birthday is lax to edaphic requirement, with the arenaceous qualitative loam with fecund, good drainage had better.

万寿菊对土壤要求不严，以肥沃。排水良好的砂质壤土为好。

He unstepped the mast and furled the sail and tied it.

他拔下桅杆，把帆卷起，系住。