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自身活化

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AR signalling can be activated in HR tumours through several mechanisms. First, activation of intracellular signal transduction pathways can sensitize the AR to castrate levels of androgens. Also, mutations in the AR can change AR ligand specificity, thereby allowing it to be activated by non-steroids or anti-androgens. Finally, overexpression of the wild-type AR sensitizes itself to low concentrations of androgens.

HRPC的AR信号通路活化机制包括:胞内信号传导途径可以增加 AR对于去势治疗后低水平雄激素的敏感性;AR的突变也可改变其对于配体的选择,使得非甾体类激素甚至抗雄激素药物也能够激活AR;此外,野生型AR的过表达也促进了自身对于低浓度雄激素的敏感性。

Mast Cells and Basophils: Development, Activation and Roles in Allergic/Autoimmune Disease

肥大细胞和嗜碱性粒细胞:发育,活化,及其在变态反应/自身免疫性疾病中的作用

Through database search, it was suggested that expression of REP5 could activate the expression of MUC1/FLO11, although the function of REP5 itself remained unclear. In this study, overexpression of REP5 did not significantly affect the drug susceptibility and germ tube formation of C. albicans.

文献报导REP5基因可以活化MUC1/FLO11的表现,虽然其自身功能尚不清楚,於白色念珠菌过量表现REP5基因时对於药物感受性和芽管形成并没有太大影响。

Anatomical description, insofar as the purpose is not activated by self-interest alone, ultimately achieves the clarification of certain characteristics of sound-making facilities.

解剖描述,在目的的这个范围无法单独被自身兴趣活化,最终澄清某些声音制造机制的特色。

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He and Nina moved to California and lived at 2005 Ivar Street, Apt.

他和Nina搬到加州,并在2005年伊瓦尔街,公寓生活。

Droperidol ( potently inhibits transfected HERGchannels and this is the probable mechanism for QT prolongation.

氟哌利多有效地抑制了转染的 HERG 钾通道,可能是 QT 间期延长的机制。

The Nazi's cruel treatment of the Jews during the Second World War is beneath contempt .

二战期间纳粹对犹太人的暴行极其可鄙。