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Ultimately, vulnerable groups of neurons atrophy and die in a process that may involve excitotoxicity (overstimulation of neurotransmitter receptors on neuronal surface membranes), collapse of calcium homeostasis, inflammation, and depletion of energy and growth factors. A form of apolipoprotein E, apoE4, contributes to the abnormal accumulation of A and tau, but probably also damages mitochondria and the cellular cytoskeleton. A , tau, apoE and -synuclein interact with many other molecules and modulate diverse signalling cascades that regulate neuronal activity and survival.

最后,易感神经元会萎缩直至死亡,原因可能有兴奋性中毒(神经递质对神经元表面受体的过度刺激引起),钙稳态失衡,炎症反应,能量和生长因子的耗尽。apoE4的产生可导致A肽和tau蛋白的异常聚合,可能也损害线粒体和细胞骨架。A肽、tau蛋白、apoE和突触核蛋白可与很多分子反应,也可调节不同信号级联反应,这些级联反应对于维持神经元活动性和生存性意义重大。

Then, base on the equivalent circuit model for cascaded coupled resonator filter, the method for measuring or computing the phase of the reflection coefficient of short-circuit terminated networks and synthesizeing all the inter-resonator couplings and resonant frequencies of the filters to be tuned is studied intensively. The phase loading effect is removed and the tuning steps are analyzed. The method based on the partial fraction expansions of admittance matrix is used to synthesize coupling matrix of the filters under tuning.

然后,通过分析级联耦合滤波器的等效电路模型,着重研究了利用测量或计算终端短路网络的反射参数的相位来综合出待调级联耦合滤波器各个腔体的谐振频率和腔体间的耦合系数的方法,并且消除了端口相位加载的影响,给出了具体的调试步骤;接着利用导纳矩阵部分分式的展开来求得待调滤波器耦合矩阵,着重研究了消除端口相位加载的方法。

This paper has presented a module-cascaded system for multi-coil direct-drive permanent magnet wind generator system with high voltage output, eliminating the grid-side step-up transformer.

针对大容量风电机组的中压变换问题,本文研究一种基于多绕组发电机的模块化级联型变换器,通过模块单元级联实现中压输出,从而省去升压变压器。

Our previous studies have shown that ubiquitous overexpression of HmgD caused hemocytes proliferation and the formation of melanotic tumors in the Drosophila larvae. To clarify the mechanism of melanotic tumors appearance,we also generated RT-PCR analysis to test the transcriptional changes of PPAE and Spn27A,which encode the key factors in the phenoloxidasecascade pathway from larvae samples of mid-third instar,late-third instar and prior to pupation relative to wild type flies.Our result showed that in the HmgD overexpression mid-third instar larvae,the expression level.of Spn27A was lower than wild type,otherwise the expression level of PPAE was higher than wild type.It suggests that overexpression of HmgD affects the PO cascade pathway.

本研究组前期工作发现,过量表达HmgD引起果蝇幼虫体内血细胞增生,并出现黑色素瘤,为探讨HmgD过量表达导致了血细胞增生即形成黑色素瘤的分子机制,本研究分别提取三龄中期、后期和相对于野生型化蛹前时刻的幼虫的RNA,首先检测了编码酚氧化酶级联反应途径中的两个关键基因PPAE,Spn27A在突变体中的转录发生变化,结果发现,Spn27A在三龄中期的表达量低于野生型,而PPAE的表达高于野生型,表明过量表达HmgD影响了酚氧化酶级联反应途径,低水平的Spn27A不足以抑制PPAE的活性,活化的PPAE催化了PPO的活性,使其转变成有活性的PO,从而促进黑色素的生成,使果蝇体内产生黑色素瘤。

As we show in detail in Figure 29.31, the result of Wnt signalling is to increase the level of -catenin, which causes it to translocate to the nucleus.

另一类途径由激酶级联的活化构成。在级联中,一系列激酶连续地相互激活,最终导致细胞核里转录因子的磷酸化和活化。

A novel cascaded and additive model based on cascaded Adaboost classifier is proposed in this paper.

本文提出了一种基于级联Adaboost的''级联--加和''融合算法。

The operating principle of cascaded multilevel converter is analyzed and an experi-ment platform based on DSP control is developed in this paper.

分析了多单元级联逆变电路的工作原理,研制了一套基于DSP控制的级联多电平逆变器的实验平台。

A new concatenated code structure is proposed which concatenates a space-time block codes with non binary low density parity check codes, which is high-level modulated without any parallel-to-serial conversion to lower the error and simplify the system structure.

提出了一种新的级联码结构,将基于有限扩域的非二进制LDPC码和空时码级联,这种结构使得非二进制LDPC码不需要串并变换直接进行高阶调制,简化了系统结构,克服了串并变换所带来的误差。

In this paper, a low complexity and memory-efficient concatenated codes called Parallel Interleaved Concatenated Gallager Codes are presented.

本文提出了一种具有低复杂度和低存储需求的并行级联码—并行交织级联Gallager码。

As an example, if you start the swag from the left, the pattern is running up on the left cascade or tail; when running across the top where the swags are, the pattern will be running horizontal; and when it comes down on the right cascade or tail, the pattern will be running down.

作为一个例子,如果你从左边的赃物,该模式运行了左边级联或尾巴;在顶部时,运行其中swags是,该模式将运行水平,而当它归结为右侧级联或尾部,该模式将运行了。

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推荐网络例句

Cynanchum Lingtai apricot production in the average weight 65 grams, the brightly-colored fruit, juicy rich, sweet-sour taste, sweet from the nucleolus, when the late Qing Dynasty famous Shaanxi, Gansu provinces, the Qing imperial court Tongzhi tribute for years.

灵台生产的牛心杏平均单果重65克,果实色泽鲜艳,汁多味浓,甜酸适口,离核仁甜,清末时就驰名陕、甘两省,清同治年间曾为朝廷贡品。

Chenopodium album,Solanum nigrum, and Amaranthus retroflexus were very susceptible to the herbicides. Polygonum persicaria and Abutilon theophrasti were relatively less susceptible to the herbicides, and Lycopersicon esculentum was not susceptible to it. The relationship between reduction rates of weed biomass and PPM values of weed leaves 2,4, and 6 days after treatment was established.

供试的6种杂草对该混剂的敏感性存在显著差异:红心藜Chenopodium album、龙葵Solanum nigrum和反枝苋Amaranthus retroflexus对该混剂最敏感,ED90值分别为47.65、71.67和29.17g/hm2;春蓼Polygonum persicaria和苘麻Abutilon theophrasti敏感,ED90值分别为96.91、114.20g/hm2;而番茄不敏感。

However, I have an idea.

不过,我有个主意。