特兰托

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

Real 4-4-1-1 should be the most appropriate defense is two-four beat Xie Maas Charan slaves, both destruction and construction, the left is to take classes about / Babu, the right is the old product characteristics / Mai Siluo Dingus, Egulanni behind in the Fischer-Tropsch support, can also be grateful 4 Transposition turns offensive, so offensive even more solid.

现实中，4-4-1-1应是最合适，双防中是谢四拍马斯查兰奴，破坏与建设并重，左翼是班拿约／巴布，右边是古积特／麦斯洛迪古斯，阿古兰尼则在费托后面支援，亦可与谢四换位轮流进攻，令进攻更立体。

MR. HARCOURT TALBOYS lived in a prim, square, red-brick mansion, within a mile of a little village called Grange Heath, in Dorsetshire.

哈考特·托尔博伊斯先生住在多塞特郡，一个叫格兰其荒原的一英里长的小村庄内，一座方方正正的红砖大厦里。

I missed a lot of skating history because I wasn't interested in it until I became a figure skater.

我到现在也没看过卡特琳娜·维特在冬奥会上的节目，也没看过布莱恩·博伊塔诺，托勒·克兰斯顿，布莱恩·奥瑟的。

International touring includes major festivals or seasons in London, Paris, Rome, Spoleto, Athens, Istanbul, Amsterdam, Madrid, Segovia, Santander, Lisbon, Turin, Reggio Emilia, Bari, Palermo, Syracuse, Catania, Cremona, Brescia, Florence, Zurich, Innsbruck, Mexico City, Guanajuato, Bogota, Caracas, Auckland, Wellington, Tokyo, Singapore, Hong Kong, Seoul, Pusan, Perpignan, Reims, Clermont-Ferrand, Cologne and Heilbronn.

悉尼舞蹈团巡演于世界各地的艺术节，包括伦敦、巴黎、罗马、斯波莱托、雅典、伊斯坦布尔、阿姆斯特丹、马德里、塞哥维亚、桑坦德、里斯本、都林、雷焦艾米利亚、巴厘、巴勒莫、锡拉丘兹、卡塔尼亚、克雷莫纳、布雷西亚、佛罗伦撒、苏黎世、伊斯布鲁克、墨西哥、瓜纳瓦托、波哥达、加拉加斯、奥克兰、惠灵顿、东京、新加坡、香港、汉城、釜山、Peerpignan、兰斯、克莱蒙费朗、科隆和海尔布隆。

Who knows? Maybe their battles with Miguel Cotto, Paul Williams, Antonio Margarito, Joshua Clottey, Zab Judah, Kermit Cintron -- and ultimately against each other -- could have equaled or even rivaled the excitement that Sugar Ray Leonard, Thomas Hearns, Wilfred Benitez, Roberto Duran, Pipino Cuevas, and Carlos Palomino created in the 147-pound division in the late 1970s and early 1980s.

谁知道呢？也许莫斯利、梅威瑟和库托、威廉姆斯、马加里托、克洛蒂、朱达、辛特龙等人比赛，最后再上演梅威瑟VS莫斯利；这或许可以和上世纪七、八十年代的次中量级车轮大战相媲美，当时的拳台主角是伦纳德、赫恩斯、班尼特兹、杜兰、库瓦斯和帕罗米诺。

The year 1569 was the beginning of the Rising of the North (November 1569 - February 1570), a major uprising was instigated by Thomas Howard, 4th Duke of Norfolk , Charles Neville, 6th Earl of Westmorland and Thomas Percy, 7th Earl of Northumberland .

这一年是1569年的北方崛起（1569年11月开始- 1570年2月），主要起义是由托马斯霍华德，第四代诺福克，查尔斯内维尔，第六威斯特摩兰和托马斯珀西，第七诺森伯兰郡伯爵伯爵公爵煽动。

Was the first president to understand television, and Howard Dean saw the value of the Web for raising money," said Ranjit Mathoda, a lawyer and money manager who blogs at Mathoda.com ."

&托玛斯·杰弗逊利用报纸赢得了总统职位，富兰克林·德拉诺·罗斯福利用广播改变了他执政的方式，约翰·F·肯尼迪是第一个认识到电视作用的总统，霍华德·迪恩看见了用网络进行筹款的好处，&兰吉特·马瑟达，这个律师兼资金经理，他在自己的博客上说。

I also published horror or dark fantasy by Carol Emshwiller, Jack Dann, Jack Cady, Jonathan Carroll, Greg Bear, Pat Cadigan, Stephen King, Lucius Shepard, Edward Bryant, Scott Baker, Simon Ings, Harlan Ellison (his "Mefisto in Onyx" won the Stoker).

我还发表过卡罗尔·艾姆什维勒、杰克·唐恩、杰克·凯迪、乔纳森·卡罗尔、格雷格·贝尔、帕特·凯迪根、斯蒂芬·金、卢修斯·谢帕德、爱德华·布莱恩特、斯科特·贝克、西蒙·英格斯、哈兰·埃里森（《 Mefisto in Onyx 》获得布莱姆·斯托克奖）的恐怖和黑暗奇幻小说。

This revised and reformed handbook of worship was largely the work of the Archbishop of Canterbury, Thomas Cranmer, and in his Preface, Cranmer explained that it was to provide common prayer in two senses of the word.

这一修订和改革手册的崇拜，主要是工作的坎特伯雷大主教托马斯克兰默，并在他的自序，克兰默解释说，它是提供共同祈祷，在两个意义上的字。

If you are unfortunate enough to the lovelorn, please tell me, I will help you out, really, please contact me!

如果你不幸失恋了，请告诉我，我会帮助你摆脱困境，真的，请联系我啦！

China's plan to cut energy intensity by 20 percent and pollutant discharges by 10 percent between 2006 and 2010 is a case in point.

中国计划在2006年到2010间降低20%的能源强度和减少10%的主要污染物排放，就是一个这样的例子。