炎症

P＜0.05. Only 33.3%of recurrent ec-topic pregnancy occurred on the non-macroscopic inflammatory salpinx.

输卵管有肉眼炎症表现者，84.9％的病例重复异位妊娠发生在炎症侧，而重复异位妊娠发生在无肉眼炎症侧者仅为33.3％(P＜0.01)。

Recent research findings show that under the circumstance of traumatic hemorrhagenic shock, in such viscera as liver, lung and small intestine, large numbers of polymorphonuclear neutrophil will congregate, sequestrate and even infiltrate, which result in tissue edema and inflammation. At the same time, due to the fact that PMN delays its apoptosis and can not be removed in time, secondary necrosis will occur and release great amount of toxic substances, such as absorbent oxygen and free radicals, which will amplify inflammation. All the above constitute the major cause of SIRS, MODS and MOF.

近来研究发现在创伤失血性休克的情况下，机体内各脏器普遍可观察到大量中性粒细胞的聚集、扣押甚至浸润，造成组织水肿，出现炎症反应，同时由于PMN凋亡延迟，不能及时被清除而发生继发性坏死，释放大量的活性氧、自由基等毒性产物使炎症反应进一步扩大，是创伤引发全身炎症反应综合征、多脏器功能不全甚至衰竭的主要途径。

Results Compared to the controlled groups,the lungs in cerebral hemorrhage groups existed hemorrhage,serosity exudation and inflammation infiltration(including macrophage and leucocyte),and the number of macrophage an...

结果与对照组比较，脑出血组肺组织存在明显渗出、出血及大量白细胞、巨噬细胞浸润，炎症细胞记数有显著意义P.05。结论脑出血可以通过引发炎症反应导致急性肺损伤；炎症反应在3~5d时最明显。

Rats in LPS group (n = 12) were intratrachealy administered 200 μg of LPS dissolved in 100 μl saline after anesthetization, rats in control group(n = 12 ) were given intratracheal 100 μl saline.

通过检测LPS组大鼠气管注入LPS后第2、4、7天肺组织炎症指标包括肺炎症积分、支气管肺泡灌洗液中性粒细胞计数、巨噬细胞计数、TNF-α、IL-1β及IL-8含量和气道黏液分泌指标包括肺组织阿先蓝—过碘酸雪夫阳染面积、免疫组化黏蛋白Muc5ac及逆转录-聚合酶链反应Muc5ac mRNA的表达，对LPS诱发大鼠肺炎症和气道黏液高分泌的改变进行动态观察。

Result: Lump static issue and acute inflammation issue lump issues of best breakthrough point that treat, and the traditional Chinese medicine can make to treat lump dissipating or limitation, create conditions for treating succeeding in in disposable operation. Accept thick liquid cellulous mastitis lump issues of 12 of patient for medical treatment altogether will it be February 2005 will it be July 2004, 11 acute inflammation one among them, this group in order to optimize healing solution treat and as treat group , regard patient of one of the acute inflammation when reviewed of the case as contrast group patient, statistical analysis is drawn : In curative effect, damage big or small treating group is it contrast group to superior to on the main improvement of symptom.

结果：肿块静止期和急性炎症期是肿块期治疗的最佳切入点，而中药治疗可使肿块消散或局限，为一次性手术治疗成功创造条件。2004年7月—2005年2月共收治浆细胞性乳腺炎肿块期病人12例，其中11例为急性炎症期，将此组病人以优化治疗方案治疗并作为治疗组，将病例回顾中急性炎症期的病人作为对照组，统计分析得出：在疗效、损伤大小、主要症状的改善上治疗组均优于对照组。

However, there were a great number of inflammatory cells, epithelial proliferation, partial breakage and defluvium of the airway epithelium in the bronchus, below the vessel mucous membrane and around lung tissues in the model control group.

正常对照组小鼠气道无明显炎症改变；模型对照组小鼠支气管、血管粘膜下和周围肺组织有明显炎症细胞浸润、气道上皮增生、气道黏液增多、气道上皮部分断裂脱落；细胞移植组小鼠气道炎症明显减轻。

PART 2:The molecular mechanisms of Nontypeable Haemophilus influenzae induced inflammatory response in respiratory epithelial cells Objective:Nontypeable Haemophilus influenzaewas traditionally considered as an extracellular pathogen in respiratory infections.In this study,we established a model of infected cells to confirm NTHI was also a facultatively intracellular pathogen.Mitogen activated protein kinasesare the important signal transduction pathway in mediating inflammatory response induced by NTHI in respiratory epithelium.In this study,we elucidate the impact of NTHI,and its SCF and EP on the expression of MAPK and subsequent proinflammatory mediators.

第二部分：NTHI致呼吸道上皮细胞炎症反应的分子机制研究目的：通过建立呼吸道上皮细胞株的体外NTHI感染模型，确认NTHI在细胞内的存活，观察NTHI及其组分(可溶性胞质成分SCF、外膜蛋白EP)对呼吸道上皮细胞MAPK信号传导通路和后续的前炎症因子表达的影响，并应用特异性ERK-MAPK抑制剂U0126、p38 MAPK抑制剂SB203580特异性阻断下游MAPK信号传导通路，观察它们对呼吸道上皮细胞分泌前炎症因子表达的影响。

Leucocytic differentiation antigen 40 sign-al access participates in regulation of inflammatory reaction accommodation of major cell component (vascular endothelial cell、vascular smooth muscle cell and macrophage), it is playing critical role in AS process, participates ather-osclerotic occurrence and development ,reside in atherosclerotic plaque cell thro-ugh CD40-CD40L interaction, induce activate by itself , express and secrete profit to happen immune response、inflammatory reaction、hemagglutination t-hrombogenic proteo-cytokine.

白细胞分化抗原40 (CD40)信号通路参与了动脉粥样硬化斑块内主要细胞成分(血管内皮细胞、血管平滑肌细胞以及巨噬细胞)炎症反应的调节，其在AS进程中扮演着关键性的角色，参与了动脉粥样硬化的发生和发展；存在于AS斑块内的细胞通过CD40-CD40L相互作用，导致自身活化，表达和分泌了有利于免疫应答发生、炎症反应、血凝和血栓形成的蛋白质细胞因子，如激活在AS斑块中的关键性细胞成分如黏附分子、炎症因子、基质金属蛋白酶等的产生，导致斑块的不稳定和破裂，而最终导致粥样硬化斑块病变的恶化。

TyPe II collagen induced arthritisln the rat ank1e joint andoVathumin as antigen induced arthritis WA in the rabbit knee joint wereestab1ish2 Qualitative evaluation of me in skin, muscle, synovium, cedilagearound joint and blood was performed by OMA3 The CIA rats were treated on day 7 after hind paw swelling and erythemaAnimals were injected intravenously with ase at a dose of 10mg/kg,tWenty minuots 1ater, one ankle of the rats random1y assigned was exPosedlaser irradiation at l00J/cm fOr l000 seconds, and another ankle wasM grouP wihout laser The other two groups is unmanipulatedcontrol group and untreated CIA group Bimaleolar ankle widthmeasuremellts were taken in all animals every tWo days using amicrometer The histopathology of the ank1e Joint was assessed at day 21after disease onset4 The pro1iferating cell nuclear antigen WCNA of CIA treated by PDT andthe HMME group without laser was doterdrined by immunohistochemiStry5 The AfA rabbits were treated on day 7 after knee swelling and erythemaThe theraPy invo1ved lntravenous injection of l0mg/kg HMME, fOl1owedby 20 minues period in dim light, and transdermal light treatment with\l00 J/cm2 fOr l000 seconds The inner sides of the treated Anees wereirradiated at first, and then the outer side did 24 hours later, the synovialtissue of the Anees joint were removed and in situ cel1 aPoptosis wasdetCCted With tednal deoxync1eotidyl transferase-mediated dUTP nickend labelingR6suIt8:l The pathologic changes of CIA and AIA include subsynovial inflammation,opovial hyPerplasia, pannus formation, cartilage and bone destructionresemble RA.2 The studies demonstrated that there are different uptake of HMME withinskin, muscle, synovium, cartilage and b1ood, and the synovium cou1draPidly uPtake more ase than skin and cartilage at the firSt 30 minuesaller intravenous injection of HMME3 The bimaleolar anke width had no different among PDT treated group,H group withollt 1aser and untreated CIA group But hlstologicalevaluation showed statiStical1y significallt reductions in synovialhyperplasia, pannus formation and cart1lage reosion, bone destruction andtotal score in PDT treated group4 Image analysis showed that the ratlo bforeen the areas of the coufltedobect to that of the entire area in PDTtreated grOup is lower than that in conirol group, but the integrated oPticaldensity had no different between the two groups5 Imape analysis showed that the ratio between the area of the countedobject to that of the e

治疗组在大鼠出现踝关节红肿后1周，炎症达到高峰时进行PDT治疗。随机治疗大鼠一侧的踝关节，另。2。一一侧作单纯HMME 对照。治疗方法是大鼠麻醉后尾静脉注入 HMME10ngkg，20分钟后踝关节照光，激光波长627.sum，功率密度 100mwcm'，照射时间1000秒，能量密度100）／。治疗后避光喂养72 小时。隔日一次测量大鼠的踝关节左右横径，治疗后两周取关节进行病理d 观察。 4。大鼠CIA模型用上述方法进行PDT治疗后，治疗组和单纯HMME 组用兔疫组化SP法检测石蜡切片的核增殖抗原。 5。兔AIA模型在关节炎出现第七天进行PDT治疗，随机治疗一侧膝关节，另一侧作自身对照。兔耳静脉注入I'arrainrelomg／Kg，20分钟后，膝关节用金蒸气激光照射，激光能量密度100）儿旷。24 ／J'时后取膝关节滑膜作病理检查，并用脱氧核昔酸末端转移酶介导的缺口末端标记法原位检测凋亡细胞。结果： 1。模型观察：CIA大鼠炎症高峰期滑膜下炎细胞浸润明显，滑膜细胞明显增殖，炎症达到高峰后二周，血管缀形成，并侵蚀和破坏软骨和骨， CIA模型病理改变与人类RA相似。兔AIA模型膝关节滑膜病理可见滑膜细胞增生，滑膜下炎细胞浸润，也与人类RA滑膜改变相似。 2。关节周围组织中光敏剂含量的测定结果表明，各组织对HMME 的吸收速度和吸收量不同，荧光值一时间曲线不同，滑膜组织比皮肤和软骨对 HMME的吸收多，在 2 0分钟时即有明显差异。 3.PDT对CIA模型的治疗结果表明：PDT治疗后关节炎组、单纯 HMME组和治疗组踝关节左右横径统计学检验差异没有显著性，但病理评分PDT治疗组滑膜增生、血管资形成及软骨破坏、骨破坏和总分比关节炎对照组和HMME对照组好，统计学检验差异有显著性。。3＿军医进修学院硕士学位论文中文摘要 4.PDT治疗组PCNA阳性细胞较对照组少，图像分析结果表明面密度（阳性染色的面积总和与统计视野面积的比值）治疗组小于对照组，统计学检验差异有显著性。。 5.PDT治疗组凋亡阳性细胞较对照组明显增多，图像分析结果单位视野内阳性细胞数和面密度PDT治疗组高于对照组，统计学检验差异有显著性。凋亡细胞核直径PDT治疗组较小，与对照组相比，统计学检验差异有显著性。结论：二。CIA、AIA的病理改变类似人类RA，可作为研究RA病因、发病机制、检查及治疗方法的模型。 2。各组织对HMME的吸收速度和吸收量不同，滑膜组织比皮。

The tendencies of HSP70 protein and mRNA expression are splenogastric hygropyrexia syndrome group＞deficiency of spleen-QI syndrome group＞normal control group,and heavy heat impairing dampness＞simultaneous onset of dampness and heat＞heavy dampness impairing heat.HSP70 expression may be prompted with the certificate type of syndrome may exist a certain degree of correlation.HSP70 was obviously expressed in pyretic syndrome.

Hp感染程度可能与胃粘膜炎症程度及炎症的活动性呈正相关，Hp感染程度越重，胃粘膜的炎症越重。5、HSP70蛋白和mRNA表达水平呈现脾胃湿热证组＞脾气虚证组＞正常对照组的趋势；而在脾胃湿热Hp组各亚型中，又呈现热重于湿＞湿热并重＞湿重于热的趋势。

He and Nina moved to California and lived at 2005 Ivar Street, Apt.

他和Nina搬到加州，并在2005年伊瓦尔街，公寓生活。

Droperidol （ potently inhibits transfected HERGchannels and this is the probable mechanism for QT prolongation.

氟哌利多有效地抑制了转染的 HERG 钾通道，可能是 QT 间期延长的机制。