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CA has been seen in the Australian Kelpie, Gordon Setter, Border Collie, Labrador Retriever, Airedale, English Pointer, Scottish Terrier, Kerry Blue Terrier, Miniature Schnauzer, and other dog breeds.

已有报道的患小脑活力缺失疾病的犬种有澳大利亚卡尔比犬、戈登雪达犬、边境牧羊犬、拉布拉多犬、万能、英国指示猎犬、苏格兰、凯利蓝、迷你雪纳瑞和一些其他品种的犬。

The highest incidence is in toy breeds (Chihuahua, Yorkshire terrier, Manchester terrier, Pomeranian, toy poodle) and in brachycephalic breeds (English bulldog, Boston terrier, Pekingese, Lhasa apso). The most common clinic findings in patients with hydrocephalus include: seizure, visual deficits, slowed learning, and dementia.

在某些玩赏犬,其发生率确相当的高(如:吉娃娃、约克夏、曼彻斯特、博美犬、小型贵宾),还有些头形圆形的种类(如:英国牛头、波士顿、北京犬及拉萨犬)水脑症的临床症状常见有:癫痫、视力不良、学习能力迟缓及痴呆。

Then the intracellular calcium concentration of neurons was measured by laser confocal scanning microscope , represented by the mean intracellular fluorescent intensity. On the ice, the cerebral cortical tissue at the infarction margin of the section after optic chiasm was rapidly dissociated about 100mg, then made into brain homogenate in low temperature. The high performance liquid chromatography was used to determine the Glu, Asp and Gly contents in homogenized brain tissue.

视交叉平面用2%TTC染色,用图像处理软件计算出脑死面积占该片脑组织面积的百分比;取视交叉前平面死边缘区皮层组织约100mg,用酶消化法制作神经细胞悬液,用激光扫描共聚焦显微镜检测皮层神经元细胞内游离钙离子浓渡,以细胞平均的荧光强度代表细胞内钙浓度;冰上迅速分离视交叉后死边缘区皮层组织约100mg,于低温下制作脑组织匀浆,用高效液相色谱法测定皮层匀浆中谷氨酸、天门冬氨酸、甘氨酸的含量。

1、Neural network correlated with LIFG and RIFG exists in normal subjects in resting-state,which might be the neural foundation in retaining the normal language function;2、The left fusiform gyrus,bilateral medial frontal gyrus and right anterior cingulum in aphasia patients after stroke showed low degree correlation,that might be one of the mechanisms of aphasia;3、The brain regions showed positive correlation with RIFG in aphasia patients only exist in right hemisphere in resting-state as well as which exist in bilateral hemisphere in normal subjects,suggested that RIFG is out of correlation with the left hemisphere in aphasia patients;4、The left thalamus showed positive correlation with RIFG only in normal subjects, inferred that the left thalamus might be an important mesomerism structure in the correlation of bilateral hemisphere;5、Left insula showed stronger positive correlation with RIFG in normal subjects than that in aphasia patients,suggested that dominant hemisphere insula is important in retaining in normal language function.

1、正常人在静息状态下即存在与LIFG和RIFG具有相关性的神经网络,该网络可能是维持正常语言功能的神经基础;2、脑死后运动性失语患者左侧梭状回、双侧额叶内侧回、右侧前扣带与LIFG的连接程度的减低可能是运动性失语的发生机制之一;3、与RIFG正相关的脑区在对照组为双侧半球分布,而在患者组仅出现在右侧半球,说明患者组RIFG与左侧半球的连接中断;4、RIFG与左侧丘脑的正相关性仅出现在正常对照组中,推测左侧丘脑可能是联系两侧半球功能区的重要中介结构;5、对照组与RIFG正相关性明显高于患者组的脑区位于左侧岛叶,说明优势半球岛叶对维持正常语言功能具有重要作用;第二部分脑死运动性失语患者语言恢复机制的静息态fMRI初步探讨目的:运用fMRI技术,采用种子点方法在静息状态下分析脑死运动性失语患者不同的恢复阶段语言功能连接方式。

Quantitative RT-PCR results showed that HTF1 is involved in the conidiation pathway,Htf1 mutant is not de-repressed in conidiophore development under non-conducive conditions.The observed phenotype of enhanced conidiophore development in the htf1 mutant may result from its defect in conidium development.It is possible that some feedback signal from conidia may inhibit further conidiophore development in M.grisea.

定量RT-PCR的结果也表明HTF1参与产孢信号途径。htf1突变体在不利于产孢条件下并没有去抑制分生孢子的发育,因此htf1突变体产生比野生型菌株数量更多的分生孢子可能是由于其无法形成分生孢子的原因导致的,这也似乎预示了在稻瘟病菌中很有可能存在一些来自分生孢子的反馈信号以进一步抑制分生孢子的发育。

The results are showed as follow:1 The biological characteristics of the pathogenThe pathogen of Eucalyptus Dieback is Cylindrocladium quinqueseptatum Figueredo.

病原菌的生物学特性桉树焦枯病的病原菌是半知菌亚门丛孢目帚柱枝孢属的帚柱枝菌(Cylindrocladium quinqueseptatum Figueredo)。

Methods The levels of serum Hcy, folate acid and VitB12 were measured in 169 patients with cerebral infarction and 110 normal controls. The condition of carotid arteries was checked by color dopper flow image in CI group. The relationship between the level of serum Hcy and folate acid, VitB12 and CAA condition were analysed. The change of serum Hey level was observed after intervention treatment of folate acid and VitB12 for 4 weeks in CI patients with hyperhomocysteinaemia.

测定169例脑死患者及110名正常对照者血清Hcy、叶酸、维生素B12水平;应用彩色多谱勒显像仪对脑死患者颈动脉进行检测;分析血清Hcy与叶酸、维生素B12水平以及与CAA程度的关系;观察叶酸、维生素B12干预4周后伴有高Hcy血症的脑死患者血清Hcy水平的变化。

At postoperative 24 hours, neurological defects were scored in five grades [0 score represent no neural impairments; 1 score: the left posterior limbs displayed decreased muscular tension and attenuated contraction reflex; 2 scores: the left posterior limbs were paralyzed, displaying obvious abduction; 3 scores: rabbit displayed obvious adductive drag with body leant to the opposite side; 4 scores: unable to walk and unconsciousness], rabbits were put to death at postoperative 48 hours, infarctional area and volume were determined and pathological changes was also observed.

术后48 h处死兔,测量死灶面积、体积,并制作病理切片观察损伤程度。主要观察指标:兔肢体功能状态,脑死灶面积和体积,病理损伤程度。结果:59只兔成功建立起死灶,模型成功率为98%。①神经功能缺失评分:56只兔为1或2分,有3只兔达到3分。②死灶平均面积为(0.465±0.012)cm2,平均体积为(0.268±0.009)cm3。

Objective:To study the differences in the types of cerebral infarction,blood coagulation function and outcomes between the infracted patients with and without diabetes mellitus.

目的:探讨脑死合并2型糖尿病与单纯脑死之间的血脂水平、凝血功能及预后的差异。方法:将70例脑死合并2型糖尿病病人设为糖尿病组,62例单纯脑死病人设为非糖尿病组,两组均给予相同的抗凝、抗血栓、脱水、降压和改善微循环等治疗。

Early diagnosis of asymptomatic cerebral infarction is difficult, we analyzed the clinical features of 56 cases of ACI, MRI shows small lesions in relative silent area of brain stem, 85.7% of which in pons.

无症状脑干死早期诊断困难,为对其早期诊断,笔者分析了56例无症状脑干死的临床特点,MRI显示病灶小、相对静区,桥脑多见,占85.7%,且多合并半球死,占92.5%,或小脑死占10%,高血压、心脏病、糖尿病为其主要危险因素。

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