有活性的

Study on the activity of PAL、POD and SOD in the corn after inoculated pathogen showed that there were big differences between resistance and susceptible materials. The changs were more stabilization in resistance materials than in susceptible materials. There is a wave crest of activities in resistance materials, but no activity wave crest in the susceptible.

通过对抗、感品种接种病原菌后，其苯丙氨酸解氨酶、过氧化物酶和超氧化物歧化酶活性变化的研究表明，抗、感材料之间的变化大不相同，抗病材料中的各种酶活性变化都比较稳定，并且有活性波峰；而感病材料中各种酶活性变化都比较大，并且没有活性波峰。

For a peptide to act as part of the host defense system or to be of pharmaceutical interest, high antimicrobial activity must be combined by low hemolytic activity. Our results indicated that the antimicrobial activity increased with increasing charge and polar angle, with charge of ＋4 and polar angle of 140° exhibiting the highest antibacterial and membrane permeabilizing activity. Higher hydrophobicity and hydrophobic moment correlated with increased hemolytic activity, thus decreasing selectivity dramatically.

胜肽要扮演宿主免疫机制的一部分或要成为新型态的抗生素不仅要有强大的抗菌活性还需要有高度的选择性，由本实验的结果发现，当抗菌胜肽的正电荷及极性角度增加时，胜肽之抗菌活性会随之增加，当抗菌胜肽的电荷为＋4而极性角度为 140°时，胜肽有最强之抗菌能力及膜渗透活性；而随著胜肽疏水性以及疏水性矩的增加，会增加溶血活性，结果反而降低了抗菌胜肽的选择性。

From the calculations, it can be found that the van der Waals interactions, the hydrophobic interactions, as well as the H-bonding interactions are crucial for the ligand binding. The 4-phenylamino group can produce strong van der Waals adn hydrophobic interactions with the nonpolar side chains of the residues deep in the binding cleft. The R^1 and R^2 substituents on the bicyclic chromophore can also produce strong van der Waals and hydrophobic interactions with the residues located at the exterior part of the binding pocket. Moreover, the two N atoms of the quinazoline can form H-bonds with EGFR, which will produce significant contribution to biological activities. The calculated nonbonded interactions between anilinoquinazolines and EGFR, as well as the information obtained from the predicted complexes, can interpret the structure-activities of the inhibitors well, which can afford us important information for structure-based drug design.

从模拟结果得到的抑制剂和靶酶之间的相互作用模式表明范德华相互作用、疏水相互作用以及氢键相互作用对抑制剂的活性都有重要的影响，抑制剂的苯胺部分位于活性口袋的底部，能够与受体残基的非极性侧链产生很强的范德华和疏水相互作用，抑制剂双环上的取代基团也能和活性口袋外部的部分残基形成一定的范德华和疏水性相互作用，而抑制剂喹唑啉环上的氮原子能和周围的残基形成较强的氢键相互作用，对抑制剂的活性有较大的影响，计算得到抑制剂和靶酶之间的非键相互作用能以及抑制剂和靶酶之间的相互作用信息能够很好地解释抑制剂活性和结构的关系，为全新抑制剂的设计提供了重要的结构信息。

Periplocoside A had stomachic toxicity against Mythimna separate and Plutella xyllostella, and had topitical toxicity against Schizaphis graminum.

杠柳新苷A对粘虫、小菜蛾有一定的胃毒活性，对麦二叉蚜有一定的触杀活性，对菜青虫、小地老虎没有胃毒活性。

AIM: To isolate bioactive secondary metabolites from the fruits of Schisandra rebriflora Rehd. et. Wils and study their effects on HIV-1 infectivity. METHODS: Inhibition of syncytia formation, HIV-1 reverse transcriptase and protease, protection of HIV-1 infected cells, level of HIV-1 p24 antigen,blockage of fusion were detected. RESULTS: A lignan compound, named rubrifloralignan A, was first isolated as a natural product with modest inhibition effects on syncytium formation and HIV- 1 replication and could protect HIV-1 infected cells with weak inhibition effects on fusion and RT, but it showed no effects on the replication of HIV-1 chronic H9 and PR. CONCLUSION: Rubrifloralignan A is an efficient anti-HIV-1 product with effect on early stage of HIV-1 replication.

目的：从红花五味子果实中寻找活性代谢产物，研究其抗HIV—1活性和作用机制方法：通过合胞体抑制、HIV-1感染细胞保护、HIV—1p24抗原测定、融合阻断、逆转录酶和蛋白酶活性分析等实验，检测分离化合物的抗HIV—1活性并探讨其作用机制一结果：红花五味子甲素能够抑制病毒诱导的合胞体形成，保护病毒感染细胞，抑制病毒在细胞内的复制对HIV-1感染细胞与正常CD4^＋细胞间的融合，逆转录酶活性有一定的抑制作用但是红花五味子甲素不抑制病毒在慢性感染细胞中的复制，也不抑制蛋白酶的活性、结论：首次从天然产物中分离得到红花五味子甲素，它对HIV—1病毒复制早期具有抑制作用

Studies also indicated that genistein exsists not only in soybeans but also in many kinds of plants such as vegetables and fruits.As a potential anticancer agent, the actional mechanisms of genistein mainly includes as follows:First, genistein can depress the activity of protein tyrosine kinase and transduction pathways for the phosphorylation of receptors and mitosis signal. So genistein can lead to cells' proliferation depressed. Second, genistein has minimal effects of phytoestrogens. It can be combined with estrogen receptor and improve the synthesis of cellular sex hormone binding glulobin, and improve the activity of UDP-glucuronyl transferase. Through these pathways, it can inhibit the cell activity of breast cancer and prostate cancer.

作为一个很有潜力的抗肿瘤物质，三羟异黄酮的作用机制主要包括：①抑制蛋白酪氨酸激酶活性，可阻抑PTK引起的受体磷酸化和有丝分裂的信号传递，导致癌细胞增殖受抑；②弱雌激素作用：可通过与体内雌激素受体结合，并可增加细胞内性激素结合球蛋白的合成，增加UDP-葡糖醛酸转移酶的活性等途径抑制乳腺癌和前列腺癌细胞活性；③拓扑酶Ⅰ和Ⅱ抑制剂，抑制细胞活性；④上调细胞周期性负性调节因子P21WAF1/CIP1的表达，使之负性调节因子作用增强；⑤可阻止胰岛素样生长因子-Ⅰ、肝细胞生长因子和神经生长因子的作用而抑制肿瘤生长；⑥其他：抗氧化作用、抑制热休克蛋白、诱导细胞凋亡、抑制新生血管生成和抑制多种耐药相关蛋白等。

These studies indicate the rationality of our molecular design based on the crystal structure of KARI complex. To obtain more KARI inhibitors with high activities, the molecular docking and 3D-QSAR methods were applied to our further studying of these amidine compounds. Two methods AutoDock3. 0.3 and DOCK4. 0 were used in molecular docking, and the calculate results accord with that of herbicidal tests in general. The CoMFA model from 3D-QSAR analysis provided useful guidance for designing highly active compounds prior to their synthesis.

这些分子作为潜在的KARI抑制剂为基于KARI的农药分子设计提供了有利指导；对部分小分子进行了合成，在除草活性初筛的近三十个化合物中，个别化合物表现出较好的除草活性，其中一个化合物wb1596对油菜和稗草具有较高的生长抑制率，并通过E.coli KARI酶活性抑制试验验证了其KARI酶的作用靶标，此化合物可以作为KARI一个有苗头的抑制剂为后续工作奠定了基础；对发现的有苗头的KARI抑制剂进行了结构修饰和优化，合成了一系列脒类化合物并确证了它们的结构，改造后的化合物与原抑制剂相比大多除草活性相当或更佳，从而表明我们基于靶标结构的分子设计的合理可靠性；对所合成一系列脒类化合物进行了分子对接和三维定量构效关系研究。

Dictamnus dasycarps Turcz. also have insecticidal activity to Ostrinia furnacalis, When the concentration was 10g/ml, correct decreased rate reached 92.86%, When the concentration was 0.675ml/g, the correct decreased rate reached 3.57%; Dictamnus dasycarps Turcz. at the range of testing concentration have lower stomach toxic effects to Ostrinia furnacalis.

通过白鲜皮对玉米螟杀虫活性的初步研究表明：白鲜皮对玉米螟表现出很强的拒食活性，在测定浓度范围内其拒食活性均在80％以上，最高可达97.22％。；白鲜皮提取液对玉米螟也有一定的毒杀活性，当浓度为10g／ml时其校正死亡率可达到92.86％，浓度为0.675ml／g时校正死亡率仅为3.57％；白鲜皮在测定浓度范围内对玉米螟的胃毒活性较低，最高才42.86％。

The present research situation about AB process in and out of our country was analyzed in this paper. In addition to a concentrated study of the factors affecting sedimentation performance of A-step activated sludge, the rule of microbe multiplication, yield of activated sludge in A-step and treatment of low-concentration sewage were also involved in this paper. The main conclusions are as follows:(1) The study on factors affecting sedimentation performance of A-step activated sludge shown that the inflow SS distinctly improve sedimentation performance of activated sludge, the less influent SS makes the sludge bulking easy, and the pythogenous sewage evidently worsen sedimentation performance of activated sludge.

本文分析了国内外AB工艺的研究现状，对A段活性污泥沉降性能的影响因素；A段的微生物增殖规律、活性污泥产量以及A段工艺处理低浓度城市污水等问题进行了试验研究，得出了以下结论：（1）对A段活性污泥沉降性能影响因素的研究表明：进水中的SS对污泥沉降性能有明显的改善作用，如果进水中SS较少，易导致污泥膨胀；而腐化污水对活性污泥的沉降性能有显著的不良影响。

Results showed that the activity of soil enzymes was obviously different.Among the different vegetation types,the activity of soil enzymes under Tilia mandshurica forests was the highest except peroxidase,whereas that under shrub-grass was the lowest.The activity of soil urease and alkaline phosphate under shrub was higher than that under the mixed forests.Activity of soil catalase and phosphate under Larix principis-rupprechtii forests was higher than that under Pinus tabulaeformis.

结果表明：不同植被类型的土壤酶活性有显著的区别，其中除过氧化物酶外，糠椴林的土壤酶活性均属最高水平，而灌草丛所有酶活性都属最低水平；灌木丛中脲酶和碱性磷酸酶活性显著高于杂木林；华北落叶松林的磷酸酶和过氧化氢酶活性均高于油松林。

If you are unfortunate enough to the lovelorn, please tell me, I will help you out, really, please contact me!

如果你不幸失恋了，请告诉我，我会帮助你摆脱困境，真的，请联系我啦！

China's plan to cut energy intensity by 20 percent and pollutant discharges by 10 percent between 2006 and 2010 is a case in point.

中国计划在2006年到2010间降低20%的能源强度和减少10%的主要污染物排放，就是一个这样的例子。