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To exploit highly bioactive natural antifungal medicaments from starfish, water-soluble starfish glycosides from Asterias rollestoni were isolated and purified by macroporous resin column and silica gel column chromatography, and their antifungal bioactivities were also examined.

为了分离纯化出具有强抗真菌活性的水溶性海星皂苷,以罗氏海盘车腕为实验材料,利用水抽提方法获得水溶性海星皂苷粗品,依次利用大孔树脂和硅胶柱层析对水溶性海星皂苷进行了纯化,并对其抗真菌活性进行了测定。

Preliminary antitumor activity in vitro of the new compounds indicated that the compounds have obvious inhibitory effect on human leukaemia cell (HL-60) and human galactophore cancer cell (MDA-MB-468) in the concentration of 10-4 mol/L. This result is a basis for further study on the synthesis and biological activity of this kind of compounds.

对所合成的10个新化合物进行了抗肿瘤体外生物活性试验,初步生物活性实验结果表明,该类化合物在浓度为10-4 mol/L时对人白血病细胞株(HL-60)和人乳腺癌细胞株(MDA-MB-468)有明显的抑制作用,在浓度为10-5 mol/L时没有明显的抑制作用,这一研究结果为进一步研究此类化合物的合成、生物活性的研究奠定了基础。

Based on these results and inferred to related reports from other labratories, it was possible to make some analyses and conclusions or inferrences:(1) CD〓AK with tumoricidal activity were induced and expanded in number througth costimulation of PBMC with anti-CD〓 McAb . and r IL-2 ;(2) CD〓AK induced and expanded in such manner did exibit more potent proliferation·ability and cytotoxicity which maintained for lonser time than those of LAK cells, thus CD〓AK was a new variety of antitumor effector cells worth to be explored;(3) CD〓AK could mediate MHC nonrestricted cytotoxicity and kill tumor target cells through inducing necrosis and apoptosis;(4) Normal mature lymphocytes of PBMC could be induced to proliferate and /or to die from apoptosis when they were costimulated by anti-CD〓McAb and rIL-2. Both proliferation and apoptosis were existing in the same cultivation system sugsesting that the presence of rIL- 2 might provide some accessary signals for apoptosis.

以这些结果为基础并参考其它有关文献可能做出如下分析与结论或推论:(1)用抗CD〓单抗和rIL-2共刺激外周血单个核细胞能诱生扩增出具有杀瘤活性的CD〓AK细胞,(2)与LAK相比,用这种方法诱生扩增的CD〓AK增殖能力强、细胞毒活性强而且维持时间长;CD〓AK是一类值得开发的抗瘤效应细胞;(3)CD〓AK能够介导MHC非限制性细胞毒活性,可以通过诱导靶细胞坏死和/或凋亡杀伤肿瘤细胞;(4)正常外周血单个核细胞中的成熟淋巴细胞在受到抗CD〓单抗和rIL-2共同刺激后既可诱导增殖也可诱导凋亡,两者并存于同一体系,推测rIL-2的存在可能为细胞凋亡提供一些辅助信号。

Through the determination of biological activities indoors, 40 strains antagonists are screened against Botrytis cinerea, Penicillium digitatum, Penicillium expansum, Alternaria kikuchiana and Physalospora piricola which are primary diseases on fruits.

经过室内生物活性测定,筛选得到40株对草莓灰霉病菌、柑橘绿霉病菌、苹果青霉病菌、梨黑斑病菌、梨轮纹病菌五种水果常见采后病害都有明显抑菌活性的细菌。

Five bistin Schiff base complexes were synthesized by the reaction of bistin dichloride with Schiff base derived from amino acids and salicylaldehyde in the presence of triethylamine,and were characterized by IR,1HNMR and MS.

二烃基锡配合物的结构类型及其具有较强的抗癌活性引起了人们极大的兴趣。大量的研究表明,有机锡化合物的生物活性主要取决于烃基,但配位基团也有一定的影响[1-3],尤其在水解、输送等过程中。某些配体对生物活性的发挥还有协同作用。

The important role of hydroxycinnamic acids,i.e.,caffeic acid, chlorogenic acid,sinapic acid,ferulic acid,3-hydroxycinnamic acid (3-HCA) and 4-hydroxycinnamic acid(4-HCA) as the pBR322 plasmid DNA-Cleaving agents in the presence of Cu ions was investigated.

我们研究了羟基肉桂酸衍生物即咖啡酸、绿原酸、芥子酸、阿魏酸、3-羟基肉桂酸(3-HCA)和4-羟基肉桂酸(4-HCA)在Cu存在下诱导pBR322质粒DNA链断裂损伤情况,结果发现HCAs的促氧化活性与它们的分子结构有密切的关系,具有邻二羟基结构和邻二甲氧基羟基结构的化合物表现出了更高的促氧化活性,其中CaA的活性最高。

The chaperone activity of porcine kidney peptidyl-prolyl cis-trans isomerase was studied.

研究猪肾脯氨酰顺反异构酶的伴侣功能时发现有活性和无活性PPIase能够提高肌酸激酶再折叠产量,抑制肌酸激酶聚沉,但是烷基。。。

Twenty-four crossbred early weaned piglets with an average initial weight of 6.10±0.35kg,weaned at 28±1 day of age,were divided into four groups to determine the effect of supplemental acidifiers on gastric acid secretion,digestive enzyme activities, and intesinal microflora.

添加0.25 %复合酸提高了胃蛋白酶(P.10)和胃酸分泌(P.10),显著提高了十二指肠内容物中胰蛋白酶和淀粉酶活性(P.05),添加1.5 %柠檬酸有提高上述两种酶活性的趋势(P.15 ,P.10),但对胃酸和胃蛋白酶分泌没有影响,显著降低了结肠大肠杆菌数量(P.05)。

Enzyme activity in supernatant from flask fermentation after 132 boors induction was 167 umL^(-1) Its expression products was active under pH2.0~8.0 and the activity was up to the the highest under pH5.5. The optimum temperature for enzyme activity was 55℃.

摇瓶诱导发酵132h后发酵液中植酸酶的活性可达167umL^(-1);表达产物在pH2.0~8.0均有活性,最适pH为5.5,最适温度为55℃。

It is shown that the AC impedance response is different when the potential alkali reactivity exists in the aggregate, and a good parallel correlation exists as compared to the results of accelerated mortar bar test.

结果表明:有潜在碱活性的集料与普通集料有不同的交流阻抗响应,可以根据其特征阻抗谱在复平面中的相对位里以及相角的大小来评定集料的碱活性,所得结果与快速砂浆棒法检测的结果有较好的相关性。

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What are your goals and strategies for growth?

你的成长目标和策略是什么?

And unto the angel of the church in Sardis write; These things saith he that hath the seven irits of God, and the seven star I know thy works, that thou hast a name that thou livest, and art dead.

3:1 你要写信给撒狄教会的使者,说,那有神的七灵和七星的,说,我知道你的行为,按名你是活的,其实是死的。

"It is a testament to making sure unemployment compensation is available, making sure we are looking out for people who have lost their jobs," she said.

"这是个实证,证明我们必须确保人们都可以得到失业补偿,确保那些失去工作的人们得到照顾。"