有害于

P16 gene is composed of two intervening sequences and three exons , and encodes p16 protein , which is the inhibiter of CDK4 and CDK6 . They can together prevent phosphorylation deactivation of pRB , and make the cell cycle blocked in G1 stage. P16 gene promoter region has a great of CpG islands , which can be methylated when some adverse factor appears , and so the genetic transcription of p16 can be inhibited , which leads to gene silencing, cell paraplasm, and tumor generate.

抑癌基因p16编码蛋白P16 ，是细胞周期蛋白CDK4和CDK6抑制剂，它阻止pRB磷酸化失活，使细胞周期阻滞于G1期。P16基因启动子区域富含CpG岛，当受到各种有害因素影响时，容易发生甲基化，从而抑制P16基因转录，导致基因沉默，细胞异常增生，导致肿瘤的发生[5]。

E.W. Dijkstra wrote his seminal paper,"Go To Statement Considered Harmful", in 1968 and David Parnas introduced the key concept of modularity and information hiding in 1972 to help programmers deal with the ever increasing complexity of software systems.

电子战斯特拉说他的开创性论文&转到声明认为有害的&，于1968年，大卫帕尔纳斯介绍了1972年的模块化和信息隐藏的关键概念，协助软件系统越来越复杂程序处理。

It is suggested that mechanisms protecting epidermis of squamata species from UVB damage may involve in (1) Physical defensive mechanism: the death epidermal layer limited UVB transmitting to the viable cells;(2) Biochemical defensive mechanism: up-regulated CAT may protect skin from reactive oxygen species which may induced by UVB. Moreover, the lipid and proteins in the β-, meso- and α-layer may absorb incident UVB and formed damaged products that were limited in the original site;(3) Cellular defensive mechanism: quick initiating of proliferation of the germinal cells and forming of the new epidermis and shedding out the damaged epidermis shortened the damage process and restricted the damage area.

1物理性防御：角质层和中层阻挡绝大部分UVB透过，最大限度地减轻生发层的损伤；(2)生化性防御：通过上调CAT活性以减轻LVB诱导的活性氧对表皮的损伤，同时角质层蛋白质和中层脂类可吸收UVB，且形成的有害产物被局限于原位；(3)细胞性防御：通过迅速启动再生修复过程形成新的表皮，及时蜕去积累了脂类过氧化产物、受损蛋白质和晒斑细胞等的受损表皮，有效防止损伤的持续和蔓延。

" Academics, however, like to define investment "risk differently, averring that it is the relative volatility of a stock or portfolio of stocks - that is, their volatility as compared to that of a large universe of stocks.

葛拉汉在智能型投资人一书的第八章便有所解释，他引用了市场先生理论，市场先生每天都会出现在你面前，只要你愿意都可以从他那里买进或卖出你的投资，只要他老兄越沮丧，投资人拥有的机会也就越多，这是由于只要市场波动的幅度越大，一些超低的价格就更有机会会出现在一些好公司身上，很难想象这种低价的优惠会被投资人视为对其有害，对于投资人来说，你完全可以无视于他的存在或是好好地利用这种愚蠢的行为。

This is because new regulations, due to come into force in 2011, will require crematoriums to filter out toxic substances such as dioxins and mercury from waste gases.

这是因为即将于2011年实施的新规定将会要求火葬场对排出的废气中的二噁英、汞等有害物质进行过滤。

This is firstly because our rulers have no interest in assuming the role of guardians over their subjects so fir as the arts and sciences are concerned, and secondly, because religious immaturity is the most pernicious and dishonourable variety of all.

我把启蒙运动的重点，亦即人类摆脱他们所加之于其自身的不成熟状态，主要是放在宗教事务方面，因为我们的统治者在艺术和科学方面并没有向他们的臣民尽监护之责的兴趣；何况这一不成熟状态既是一切之中最有害的而又是最可耻的一种。

But in private revenges, it is not so.

但报私仇却不会有这般幸运；与此相反，欲报私仇者过的是巫师一般的生活，他们活着时于人有害，死去则可叹可悲。

The invention is characterized in low check limit, high sensitivity, repeat application, and wide check air range, and the invention can be used to check various volatile harmful gas, more particularly check the discharge and leaked harmful gas as NO2, SO2, NO, CO, H2S and carbonyl chloride.

由于本发明传感器具有检测限低，灵敏度高，可重复使用，检测气体范围广等特点，故本发明可广泛用于检测人类生产生活环境中的各种挥发性有毒气体，特别适用于工业生产中NO 2 、SO 2 、NO、CO、H 2 S，及光气等有害气体排放合格性的检测及泄漏的检测。

RoHS Directive stipulates that from July 1, 2006, All member states should invest in the market to ensure that the restrictions on the use of electronic and electrical equipment, lead, mercury, cadmium, hexavalent chromium, polybrominated diphenyl ether and polybrominated biphenyls and other hazardous substances.

RoHS 指令规定，从2006年7月1日起，各成员国应确保在投放于市场的电子和电气设备中限制使用铅、汞、镉、六价铬、多溴二苯醚和多溴联苯等有害物质。

God created all people, in fact every life has she survived the reasons and authority, but on humanity, as long as people useful even save their lives, the dog can no longer harmful, on the contrary, the dog's style actually more easily affixed mankind, and not as individual contracted the disease in the dog, the onset of the disease when the bad moves on the large-scale massacre of dogs?

上帝产生了所有的人，事实上每生活她已经活的比理由和权威久，但是在人性身上，像人一样的长有用的甚至解救他们的生命，狗能不再有害，在相反者身上，狗的风格实际上更容易使人类附于了，而且不如个体在狗，疾病的攻击中感染了疾病当在狗的大规模大屠杀上的差劲的移动？

If you are unfortunate enough to the lovelorn, please tell me, I will help you out, really, please contact me!

如果你不幸失恋了，请告诉我，我会帮助你摆脱困境，真的，请联系我啦！

China's plan to cut energy intensity by 20 percent and pollutant discharges by 10 percent between 2006 and 2010 is a case in point.

中国计划在2006年到2010间降低20%的能源强度和减少10%的主要污染物排放，就是一个这样的例子。