损伤

For the definition of two damage variables,damage variable and damage evolution equation are derived respectively.

针对两种损伤的定义，给出了损伤变量和损伤演化方程，同时用损伤力学定义了边坡的安全系数为极限损伤与最大损伤变量之比，并给出了应用算例。

This article mainly simulates gradually damage destruction process of rock, major in determinationg the definition of rock three-dimensional damage tensor, simplify to the damage tensor and obtain its engineering calculation method, and obtains the basic expression form of equivalent stress by equivalent stress assumption, symmetrization to the actual stress, thus obtains construction relation of the festival principle of three-dimensional damage rock mass, finally couples elasticity- plasticity with damage in the finite element equation, with reference to elasticity-plasticity gradually degenerated method thought, simulates rock damage to advance gradually the destruction process in finite element method, draws up elasticity - plasticity and damage coupling two-dimension finite element procedure with the C language in the VC contact surface, by simulating experiment destroyed process, acquires destruction image and the axial load distortion curve of model, agreement with the experimental result.

本文主要模拟岩石渐进损伤破坏过程，确定岩石三维损伤张量的定义，对损伤张量进行简化计算并得出其工程计算方法，采用等效应力假设得出有效应力的基本表达形式，对有效应力进行对称化，得出节理损伤岩体的三维本构关系，在有限元方程中实现弹塑性和损伤耦合；借鉴弹塑性渐进退化方法的思想，采用有限元的方法模拟岩石损伤渐进破坏过程，用C++语言在VC界面编制了弹塑性和损伤耦合的二维有限元程序，通过模拟已有的实验破坏过程，得出模型的破坏图像和轴向荷载变形曲线，与实验结果基本一致。

objective:to study the changes of dynamic electrocardiogram in patients with brain injury.methods:fifty-six patients with acute brain injury were recruited in this study.the glasgow coma scale, the initial computed tomogram and ambulatory electrocardiogram were performed in all subject.data were analyzed according to different place and severity of brain injury.results:ecg abnormalities were found in 32 patients out of 56 patients with acute head injury(57.14%).

目的：观察脑损伤患者的动态心电图改变，了解急性脑损伤致心电异常的特点及其与损伤部位和严重程度的关系。方法：选取我院急性脑损伤患者56例，经glasgow评分分型，脑ct确定损伤部位，并行24h动态心电图检查，观察急性脑损伤后心电异常的发生情况，并根据脑损伤部位和严重程度分组观察，以了解其心电异常的特点。

Methods①The animal model of braincontusion caused by free drop hammer was established.②The injuredtissue of rat brain were stained by TUNEL for apoptosis,immunohistochemistry for Caspase-3 and Feulgen"s for DNA. Image analysistechnique and the statistical method were employed to explorate thetemporal changes of injury time.③The DNA was extracted from ratcontusive tissue of brain and assayed by gel electrophoresis toinvestigate the relationship between the DNA fragmentation and injurytime.④One handred and seventeen cases of death from traumatic braininjury were retrospective researched to investigate the characteristicof TBI in forensic medicine.⑤The contusive tissue of human brain werestained by TUNEL, Caspase-3 immunohistochemistry and Feulgen"s methodsin the same way to analyze and disclose the linear relationship betweentemporal changes with injury time.

方法①建立大鼠自由落体打击脑损伤模型；②对不同损伤时间组的大鼠脑挫伤组织进行TUNEL、Caspase-3免疫组化、Feulgen's DNA染色，结合图像分析技术和统计学分析，探讨脑挫伤后神经细胞凋亡、DNA片段化和含量的时序性变化；③提取大鼠脑挫伤组织DNA进行琼脂糖凝胶电泳分析，观察DNA片段化随损伤时间的变化特点；④对117例颅脑损伤致死案例进行回顾性分析，探讨其法医学特点；⑤选择不同损伤时间的人脑挫伤组织同样进行TUNEL、Caspase-3免疫组化、Feulgen's DNA染色和分析，观察上述指标与损伤时间的关系。

In the model, the evolution equation of damage was introduced and the time-dependent effect and nonproportional path effect was taken into account.

该模型中引入了损伤演化方程，考虑了时相关效应和非比例效应，并将损伤分为时无关损伤和时相关损伤两部分，并采用不同的损伤演化方程来描述这两类损伤。

1Cubic millimeter tissue sampling was fixed with the mix of 1% glutaraldehyde and 4% paraform in 4℃.

利用兔后腿软组织损伤、海水浸泡模型，分别于损伤后浸泡于海水中2小时，浸泡后分别进行各种低渗盐水冲洗，分别于干预处理后1h、3h、6h、8h、12h，在损伤周围0.5cm范围内的肌肉组织中取材，0.5cm3损伤组织用4%福尔马林固定，HE染色，光镜下观察损伤组织的细胞浸润情况，用免疫组化法检测受伤肌肉组织凋亡相关基因Caspase3表达情况；1mm3损伤组织用1%戊二醛一%多聚甲醛混合固定液(pH7.4 ) 4℃固定，电镜观察其细胞凋亡及细胞膜、线粒体等结构的变化；生化检测Na+，K+-ATPase活性，了解其组间的差别。

objective to search the factors of liver injury via the anit-induced liver injury in rats.methods male sprague-dawley rats,were divided into 4 groups,data were analyzed using a completely randmized factorial anova and linear correlation.results after anit intoxication,the necrosis of hepatic cell and neutrophil infiltration im periportal region of the liver were observed in liver setions.jinshisan can reduce the alt,the tbil.pla2 correlated positively with alt、akp and tbil.conclusion the severity of anit-induced liver injury correlated positively with the pla2.jinshisan can protect against the rat anit-induced liver injury.

目的 拟通过对α－萘异硫氰酸酯诱导大鼠肝损伤发病机理的探讨，对引起肝损伤的因素进行系统的研究。方法选择s-d大鼠，雄性，随机分4组，检测数据以平均值±标准差表示，采用方差分析，相关分析进行统计学处理。结果s-d大鼠经anit染毒后，病理切片显示肝损伤明显，汇管区有大量中性粒细胞浸润。经金石散及地塞米松治疗后，生化指标均有所下降，中药金石散优于地塞米松，血生化指标与pla2活性相关分析显示，呈正相关。结论 anit诱导的肝毒性损伤程度与肝组织匀浆pla2活力呈正相关，应用抑制剂降低pla2活力，肝损伤程度也减轻，中药金石散具有降低pla2活性，减轻肝毒性损伤。

Result: Porosis and inflammatory cell infiltration in the spinal cord, rupture of muscle bundles, hypertrophia and over growth of muscle cells and collagens, and inflammatory cell infiltration in the bladder wall could been seen under HE dyeing. Nissal dyeing showed the decrease of neurons at the injured segment, upper and lower segments of the spinal cord. Result of immunohistochemistry showed there were caspase-3 positive expression in all the segments. The injured spinal cord and bladder expressed significantly more caspase-3 positive results (P.0l), upper and lower segments were lower than the injured segments (P.01), but higher than the control team (P.0l).

结果：HE染色发现脊髓损伤后脊髓内空洞形成、炎性细胞浸润等病理学变化，膀胱壁中可见到肌束断裂、肌细胞肥大增生、胶原增生、炎性细胞浸润等病理学改变；Nissal染色显示脊髓损伤后损伤节段及其上、下节段均出现神经元数量的减少；免疫组化结果表明3组均有不同程度的caspase-3表达，损伤组脊髓和膀胱内膜caspase-3表达较正常组显著增加(P.01)，损伤上段及下段caspase-3表达较损伤节段为少(P.01)，但均高于正常对照组(P.01)。

To pay attention to carry out effective cardiopulmonary resuscitation, hemostasis by compression and deep vein intubation rapidly in the initial stage of emergency. The carotid shunt tube plays an important role in severe carotid injury and re-establishment process. We use external jugular vein to transplant and re-establish,which are rung with artificial blood vessels for the long distance carotid injury and achieved the best result. We expose as fully as possible for the hepatic venae and the posthepatic post caval injury,and adopt effective methods to stop bleeding and repair. The application of blood shunt pump could raise the success rate for those severe patients. The self-double vastransplantation with both ends being all trousers-style one opening solve some problems such as there are no suitable caliber self-transplantation blood vessels and the artificial blood vessels are easy to occur obliteration for long-term and so on for the great or middle blood vessels.We use improved Fogarty duct and anterograde intubation to eliminate thrombus could eliminate thrombus effectively and avoid accessory injury for the deep vein injury and extensive thrombosis.

抢救初期要注意进行有效的心肺复苏、压迫止血和快速进行深静脉插管；颈动脉转流管在严重颈动脉损伤重建过程中有重要作用；对长距离颈动脉损伤用颈外静脉移植外环包人造血管重建，可取得最佳效果；对肝静脉及肝后下腔静脉损伤，要充分暴露，采用有效方法止血和修复，对病情极危重的凶险性出血者，血液转流泵的应用可提高成功率；对大、中血管损伤，两端均为裤式单开口自体双血管移植，解决了无适宜口径自体移植血管和应用人造血管远期易闭塞等问题；对深静脉损伤并广泛血栓形成者，应用改进的Fogarty导管和顺行插管取栓法，可有效取栓并避免了副损伤。

To pay attention to carry out effective cardiopulmonary resus-citation,hemostasis by compression and deep vein intubation rapidly in the initial stage of emergency.The carotid shunt tube plays an important role in severe carotid injury and re-establishment process.We use external jugular vein to transplant and re-establish,which are rungwith artificial blood vessels for the long distance carotid injury and achieved the best result.We expose as fully as possible for the hepatic venae and the posthepatic post caval injury,and adopt effective methods to stop bleeding and repair.The application of blood shunt pump could raise the success rate for those severe patients.The self-double vastransplantation with both ends being all trousers-style one opening solve some problems such as there are no suitable caliber self-transplantation blood vessels and the artificial blood vessels are easy to occur obliteration for long-term and so on for the great or middle blood vessels.We use improved Fogarty duct and anterograde intubation to eliminate thrombus could eliminate thrombus effectively and avoid accessory injury for the deep vein injury and extensive thrombosis.

抢救初期要注意进行有效的心肺复苏、压迫止血和快速进行深静脉插管；颈动脉转流管在严重颈动脉损伤重建过程中有重要作用；对长距离颈动脉损伤用颈外静脉移植外环包人造血管重建，可取得最佳效果；对肝静脉及肝后下腔静脉损伤，要充分暴露，采用有效方法止血和修复，对病情极危重的凶险性出血者，血液转流泵的应用可提高成功率；对大、中血管损伤，两端均为裤式单开口自体双血管移植，解决了无适宜口径自体移植血管和应用人造血管远期易闭塞等问题；对深静脉损伤并广泛血栓形成者，应用改进的Fogarty导管和顺行插管取栓法，可有效取栓并避免了副损伤。

He is the most remarkable man that I have ever known.

他是我知道的人中最值得注意的人。

Increased appearance of lymphocele was noticed in patients with diabetic nephropathy, congenital malformations of the urinary tract, and inflammatory diseases, including glomerulopathy and extraglomerular ones, after high-voltage radiotherapy and after removal of the renal graft.

经过高压放射疗法和切除移植肾后，在糖尿病肾病患者、泌尿系统先天性畸形患者和炎症患者身上发现淋巴囊肿有所增加，包括肾小球病和球外疾病等。