抑制剂

The cell growth and the releasing rate of urease from bacteria and actinomycete in the presence of different nBPT concentrations were examined.

研究了脲酶抑制剂nBPT对土壤中脲酶活性和细菌、放线菌生长及发酵产酶的影响。

Many antibodies against pro-inflammatory cytokines and inhibitors of inducible NO synthase have been produced, but most of them are agents targeting one factor and cant efficiently block the development of systemic inflammation.

尽管已经研制出许多抗促炎细胞因子抗体及诱生型NO合酶(inducible NO synthase，iNOS)抑制剂等，但多为单因素抗炎制剂，不能有效地阻断全身性炎症的发展。

This study "confirms for me that there does not appear to be harm in the use of ACE inhibitors or ARB agents right up until the time the patient goes on dialysis, and they should be continued after starting dialysis," said nephrologist Leslie Spry, MD, who was not involved in this research. Dr. Spry, who is medical director of the Dialysis Center of Lincoln, Nebraska, and a spokesperson for the National Kidney Foundation, told Medscape Nephrology that these findings demonstrate that "the benefit is still there late in the disease, and even after the onset of dialysis."

未参与此研究的肾脏科医师Leslie Spry表示，此研究确认了使用ACE抑制剂或ARB制剂没有明显伤害，直到病患开始接受透析，且在开始透析之后还可以继续使用；国家肾脏基金会发言人、内布拉斯加州林肯透析中心医疗主任Spry医师向Medscape Nephrology 表示，这些发现点出了RAS抑制剂的好处在疾病后期、甚至开始透析之后仍然存在。

Studies also indicated that genistein exsists not only in soybeans but also in many kinds of plants such as vegetables and fruits.As a potential anticancer agent, the actional mechanisms of genistein mainly includes as follows:First, genistein can depress the activity of protein tyrosine kinase and transduction pathways for the phosphorylation of receptors and mitosis signal. So genistein can lead to cells' proliferation depressed. Second, genistein has minimal effects of phytoestrogens. It can be combined with estrogen receptor and improve the synthesis of cellular sex hormone binding glulobin, and improve the activity of UDP-glucuronyl transferase. Through these pathways, it can inhibit the cell activity of breast cancer and prostate cancer.

作为一个很有潜力的抗肿瘤物质，三羟异黄酮的作用机制主要包括：①抑制蛋白酪氨酸激酶活性，可阻抑PTK引起的受体磷酸化和有丝分裂的信号传递，导致癌细胞增殖受抑；②弱雌激素作用：可通过与体内雌激素受体结合，并可增加细胞内性激素结合球蛋白的合成，增加UDP-葡糖醛酸转移酶的活性等途径抑制乳腺癌和前列腺癌细胞活性；③拓扑酶Ⅰ和Ⅱ抑制剂，抑制细胞活性；④上调细胞周期性负性调节因子P21WAF1/CIP1的表达，使之负性调节因子作用增强；⑤可阻止胰岛素样生长因子-Ⅰ、肝细胞生长因子和神经生长因子的作用而抑制肿瘤生长；⑥其他：抗氧化作用、抑制热休克蛋白、诱导细胞凋亡、抑制新生血管生成和抑制多种耐药相关蛋白等。

Intragastric pH monitoring were conducted 4 hours before operation and continued for 72 hours in all of these patients.

目的：探讨抑酸剂质子泵抑制剂和H2受体拮抗剂对颅脑围手术期患者胃酸分泌的影响。

P16 gene is composed of two intervening sequences and three exons , and encodes p16 protein , which is the inhibiter of CDK4 and CDK6 . They can together prevent phosphorylation deactivation of pRB , and make the cell cycle blocked in G1 stage. P16 gene promoter region has a great of CpG islands , which can be methylated when some adverse factor appears , and so the genetic transcription of p16 can be inhibited , which leads to gene silencing, cell paraplasm, and tumor generate.

抑癌基因p16编码蛋白P16 ，是细胞周期蛋白CDK4和CDK6抑制剂，它阻止pRB磷酸化失活，使细胞周期阻滞于G1期。P16基因启动子区域富含CpG岛，当受到各种有害因素影响时，容易发生甲基化，从而抑制P16基因转录，导致基因沉默，细胞异常增生，导致肿瘤的发生[5]。

Result PLAP activity was inhibited by PCP....

PCP是PLAP的非竞争性抑制剂，其K_1为3.49mmol/L。④结论PCP对PLAP有抑制作。

It can inhibit the transmethylation activity through conjugating with DNMT1 and forming a covalent compound when conjugated with replicating DNA molecule. Then the formation of hypomethylated daughter chain makes the demethylation function ture.

体外实验已经证实DNA甲基转移酶抑制剂5Aza-dc通过去甲基化作用可使多种含有CpG岛的高甲基化抑癌基因重新表达，从而恢复抑癌功能，这一研究结果对于肿瘤的基因治疗提供了一个新的思路。

DATA SYNTHESIS:（1）According to the synthesized methods, immunosuppressant could be classified into zymolytic products of microbes, complete organic synthetical, semisynthetic compound and biologic agent, and according to the development, it could be divided into the first to fourth generation immunosuppressant.

资料综合：①分类：免疫抑制剂根据合成方法可分为微生物酵解产物、完全有机合成物、半合成化合物和生物制剂；根据其发展状况可分为第1～4代免疫抑制剂。

Methods After treated with a specific demethylating agent,Aza and acetylating agent, TSA, the status of 5'CpC island methylation of ING1b gene in HT29 human colon cancer cell line was analyzed using methylation specific polymerase chain reaction,and the level of histone acetylation was analyzed by chromatin immunoprecipitation,and reverse transcription polymerase chain reactionwas used to examine ING1b mRNA expression.

应用特异性DNA甲基转移酶抑制剂5-氮-2'-脱氧胞苷（5-Aza-2'-dc，以下简称Aza）及组蛋白去乙酰化酶抑制剂曲古抑菌素A作用人结肠癌细胞株HT29后，用甲基化特异性PCR检测该ING1b基因核心启动子区域CpG岛甲基化情况，用染色质免疫沉淀检测其乙酰化组蛋白绑定的DNA情况，并用逆转录聚合酶链反应检测ING1bmRNA表达。

I'm strongly against the death penalty — it's an eye for an eye.

我不赞成死刑——这是以牙还牙的报复行为。

And to get you the support you need, we're enlisting all elements of our national power: our diplomacy and development, our economic might and our moral suasion, so that you and the rest of our military do not bear the burden of our security alone.

并给你们所须的支援，我们正徵召国家所有各种的力量：我们的外交及发展，我们的经济力量与道德劝说，所以你们与其他军人不须要孤独地负起国家安全的责任。