大黄

After IV administration of Aloin and Isobarbaloin mixture solution to six rabbits, the plasma level-time profiles of Aloin and Isobarbaloin were adequately described by an open two-compartment model.

六只家兔於试验设计下，进行指标成分混合液在不同剂量静脉给药试验，结果显示芦荟大黄苷及异芦荟大黄苷在家兔体内之经时浓度变化，初步呈现二室开放模式的趋势。

At the IV dose of 20 and 30 mg/kg, Aloin and Isobarbaloin result appear the mean terminal eliminate half-life（T1/2 β）were 54.1±28.4; 28.7±18.3 and 36.9±21.9;49.7±17.1 min, respectively. The mean area under the serum concentration curve（AUC0-∞）were about 411.655± 13.027;318.213±19.924 and 701.336±116.631;573.278± 86.870μg min/mL, respectively. The mean drug clearancewere 0.165±0.011;0.214±0.016 and 0.149±0.030;0.182±0.035 L/min, respectively.

若静脉注射剂量20和30 mg/kg后，其芦荟大黄苷及异芦荟大黄苷分别平均末端排除半衰期（T1/2 β）为54.1±28.4；28.7±18.3和36.9±21.9；49.7±17.1 min，平均稳定状态分布体积为7.668±3.155；6.343±3.522和5.146±2.490；8.525±2.683 L，平均曲线下面积（AUC0-∞）为411.655 ±13.027；318.213±19.924 和701.336±116.631；573.278±86.870 μgmin/mL，平均血浆中药物最高浓度为23.920±5.669；30.442 ±7.537和57.920±27.690；36.373±14.174 μg/mL，平均药物之清除率为0.165±0.011；0.214±0.016和0.149±0.030；0.182±0.035 L/min。

At the IV dose of 20 and 30 mg/kg, Aloin and Isobarbaloin result appear the mean terminal eliminate half-life（T1/2 β）were 54.1±28.4; 28.7±18.3 and 36.9±21.9;49.7±17.1 min, respectively. The mean area under the serum concentration curve（AUC0-∞）were about 411.655± 13.027;318.213±19.924 and 701.336±116.631;573.278± 86.870μgE min/mL, respectively. The mean drug clearancewere 0.165±0.011;0.214±0.016 and 0.149±0.030;0.182±0.035 L/min, respectively.

若静脉注射剂量20和30 mg/kg后，其芦荟大黄苷及异芦荟大黄苷分别平均末端排除半衰期（T1/2 β）为54.1±28.4；28.7±18.3和36.9±21.9；49.7±17.1 min，平均稳定状态分布体积为7.668±3.155；6.343±3.522和5.146±2.490；8.525±2.683 L，平均曲线下面积（AUC0-∞）为411.655 ±13.027；318.213±19.924 和701.336±116.631；573.278±86.870 μgEmin/mL，平均血浆中药物最高浓度为23.920±5.669；30.442 ±7.537和57.920±27.690；36.373±14.174 μg/mL，平均药物之清除率为0.165±0.011；0.214±0.016和0.149±0.030；0.182±0.035 L/min。

The animals were then killed,color of colon was observed and score of degree of nigrities was evaluated.

结论用大黄可致豚鼠实验性结肠黑变病，黑变程度与大黄剂量及时间相关。

Rhubarb - Rhubarb is technically a vegetable (although the United States Customs Court in New York ruled it a fruit in 1947) and belongs to the Polygonaceae family.

大黄 -大黄技术上是蔬菜（尽管美国海关在纽约法院裁定它的果实在1947年）和属于蓼家庭。

Results:TLC method could be used for Rhaponticin examination in both Rhubarb and Processed Rhubarb.

结果：土大黄苷薄层检查法对大黄药材及饮片的检查均适用。

The said medicine contains rheinic acid and rheinate and is prepared into oral water solution or capsule with daily taken dose not greater than 200mg.

一种治疗糖尿病肾病的药，它含有大黄酸和大黄酸盐。它可以制成水溶液或胶囊口服，日剂量不大于200mg／日。

Objective To explore the possible molecular mechanism that rhein antagonizes the effect of TGFβ1 on glomerular mesangial cells. Methods Cultured C57/SJL mouse mesangial cells were used in the in vitro study.

目的 研究大黄酸对系膜细胞葡萄糖转运蛋白1(GLUT1)及葡萄糖摄入的影响，探讨大黄酸拮抗TGFβ1作用的可能机制。

Objective: To detect the spectral properties of aloe-emodin in different solvents, and provide the experimental data for the photodynamic study of aloe-emodin.

目的：检测芦荟大黄素在不同溶剂体系中的光谱特性，为芦荟大黄素的光动力学研究提供试验资料。

In our studies, the treatment of colo 205 cells with 10,20,30,40 or 50 μM Aloe-emodin will decerased the cell viability in a dose- and time-dependent manner.

在我们的实验结果中发现，大肠癌细胞给予芦荟大黄素10、20、30、40及50 μM处理后，结果发现芦荟大黄素对於细胞毒性的产生，具有时间上及剂量上影响。

He and Nina moved to California and lived at 2005 Ivar Street, Apt.

他和Nina搬到加州，并在2005年伊瓦尔街，公寓生活。

Droperidol （ potently inhibits transfected HERGchannels and this is the probable mechanism for QT prolongation.

氟哌利多有效地抑制了转染的 HERG 钾通道，可能是 QT 间期延长的机制。