大经

On such day: there develops, occurs, exists or comes into force any event whereby in the reasonable opinion of the Underwriter, the success of the Open Offer or the business or financial condition and/or prospects of the group would, might be or is likely to be adversely affected or which makes it inadvisable or inexpedient to proceed with the Open Offer; or there comes to the notice of the Underwriter or the Underwriter shall have reasonable cause to believe that any of the undertakings or other obligations expressed to be assumed by or imposed on the Company under the underwriting agreement have not been complied with in any material respect; or there comes to the notice of the Underwriter or the Underwriter shall have reasonable cause to believe that any of the representations or warranties given by the Company under the underwriting agreement was untrue, incorrect, misleading or inaccurate in any material respect which adversely affect the success of the Open Offer; which in the reasonable opinion of the Underwriter: is or may or will be or is likely to be adverse to, or prejudicially affects, the business or financial or trading position or prospects of the group taken as a whole; or is or may or will be or is likely to adversely affect the success of the Open Offer and/or makes it impracticable, inexpedient or inadvisable for any part of the underwriting agreement and the Open Offer to be performed or implemented as envisaged; or make or will or is likely to make it impracticable, inexpedient or inadvisable to proceed with the Open Offer or the delivery of the convertible non-voting preference shares on the terms and in the manner contemplated by the Prospectus or the underwriting agreement.

Samson Paper Holdings Limited Provisional Allotment Account 倘于接纳可兑换无投票权优先股份及付款的截止时间后两个营业日下午六时正前任何时间出现下列事件，则公开发售包销商Quinselle Holdings Limited可于该日期下午六时正前任何时间向本公司发出书面通知以终止包销协议：因任何事件之出现、发生、存在或生效而令包销商合理认为将会、可能或极大机会对公开发售能否顺利进行或本集团之业务或财政状况及╱或前景构成不利影响，或致使进行公开发售实属不合理或不合宜；或包销商注意到或包销商有合理理由相信本公司并无于所有重大方面遵守根据包销协议列明须承担或获委予之任何承诺或其他责任；或包销商注意到或包销商有合理理由相信本公司根据包销协议作出之任何陈述或保证于任何重大方面属失实、错误、误导或不准确而对公开发售能否顺利进行造成不利影响；而包销商合理认为：经已或可能或将会或大有可能对本集团整体业务或财政或经营状况或前景造成不利影响或损害；或经已或可能或将会或大有可能对公开发售能否顺利进行构成不利影响及╱或使持续进行使包销协议的任何部份或公开发售的进行或落实为不实际、不合适或不合宜；或按发售章程或包销协议拟订之条款及方式持续进行公开发售或寄发可兑换无投票权优先股份导致、将为或大有可能为不实际、不合适或不合宜。

Methods The rat models of ARF were made with mercury perchloride by intraperitoneal injection.Five minutes later,the rats in nmhaFGF group and model group were respectively injected with 40 μg·kg-1 nmhaFGF and normal saline by lingual vein.The rats in control group were injected with normal saline.At the time of 30 min,90 min,24 h and 48 h,the contents of blood urea nitrogen,creatinine and urine protein were detected respectively.

腹腔注射氯化汞复制大鼠急性肾功能衰竭模型，5 min后，nmhaFGF组经舌静脉注射nmhaFGF 40 μg·kg-1，模型组经舌静脉注射等剂量的生理盐水，对照组大鼠麻醉后注射生理盐水，在30 min、90 min、24 h、48 h取血检测大鼠血液中尿素氮、肌酐和尿液中蛋白含量的变化。

The constant nutritional arteries of the great saphenous vein-saphenous nerve on the medial foot: Perforator at medial side of the tendon of the tibialis anterior ,it is （2.27±0.43）cm distal to the intermalleolar line .it passes across the medial side of the tendon of the tibialis anterior and pierces the deep fascia between the upper and lower bundle of the inferior extensor retinaculum with a diameter of （0.72±0.04）mm;The length of it after piercing the deep fascia is （7.3±0.6）mm,It has an emerging rate of 95%; Perforator between tendons ,it is （3.02±0.39）cm distal to the intermalleolar line;it pierces the deep fascia between the tendons of tibialis anterior and extensor digitorum longus with a diameter of (0.57±0.06)mm ;The length of it after piercing the deep fascia is （7.4±0.6）mm .It has an emerging rate of 94%; A constant distal fascial perforator pierces the deep fascia between abductor hallucis muscle and medial side of first metatarsal bone （1.97±0.23）mm distal to the first metatarsophalangeal joint with a diameter of (0.50±0.03)mm.

足内侧大隐静脉-隐神经营养血管近端来自内踝前动脉较为恒定，外径较大的穿支有：踝间线远端（2.27±0.43）cm，经胫骨前肌腱内侧、伸肌下支持带上、下束间穿出，外径(0.72±0.04)mm ，穿出深筋膜的长度为（7.3±0.6）mm，出现率为95%；踝间线远端（3.02±0.39）cm，经胫骨前肌腱与趾伸肌腱穿出，外径(0.57±0.06)mm，穿出深筋膜的长度为（7.4±1.2）mm ，出现率为94%；3远端来自交通支最为恒定，外径较大的穿支于踇展肌与第一跖骨内侧缘之间穿出深筋膜，距第一跖趾并节近端（1.97±0.23）cm，直径（0.50±0.03）mm，穿出深筋膜的长度为（6.5±0.5）mm，出现率为100%。

The unoperated sides of the treated animals also served as controls. Six normal rats were treated as normal control group. Three different siRNA plasmid solution containing RC2-Ⅰ, MAFbx-Ⅱ, CON (50μl , 0.8μg/μl)was injected and transfected by electroporation as methods mentioned above, respectively. The changes of RC2 and MAFbx mRNA levels and RC2 protein levels after 3 days were determined by real-time quantitative PCR and Western blot, respectively. On postoperative 2, 3 and 4 weeks, the rate of wet muscle weight preservation, mean diameter of muscle fiber and mean cross-section area of muscle fiber and muscle protein content were checked and then compared between group CON and group RC2 or group MAFbx, respectively. The differences between groups were analyzed by one-way ANOVA. Ultrastructural changes of muscle fiber were observed at 2, 3, 4 weeks postoperation.Results GFP plasmid was efficiently deliverd into muscle by electroporation and robust GFP expression in muscle could be observed more than three weeks. Histology shows that injected plasmid DNA diffuses extensively in muscle tissue.

1、健康雌性SD大鼠18只，随机分为电穿孔组和非电穿孔组，每组9只，制作右下肢趾长伸肌失神经支配模型；EP组为将质粒pEGFP-N1溶液50μl(0.8μg／μl)注射入右趾长伸肌后，立即于两侧腱腹交接处给予电穿孔，电穿孔参数为：电场强度为200V／Cm，脉冲100μs，频率1Hz，施加10次脉冲；NEP组仅质粒pEGFP-N1溶液注射；转染后1、2、3周，荧光显微镜下观察趾长伸肌中GFP的表达情况，转染后1周行Western印迹检测趾长伸肌中GFP蛋白的表达情况，检测和优化体内转染效率。2、健康雌性SD大鼠78只，随机分为失神经对照组、RC2基因治疗组(RC2组)，MAFbx基因治疗组，每组24只，制作右下肢趾长伸肌失神经支配模型，余6只为正常组；分别将含CON、RC2、MAFbx基因的siRNA重组质粒注射入趾长伸肌，之后给予电穿孔，方法同上；治疗后3天实时定量PCR和Western印迹检测各组中RC2或MAFbx基因的mRNA和蛋白的表达变化，治疗后2、3、4周检测各组肌湿重维持率、肌细胞直径和肌细胞截面积，肌细胞超微结构变化以及肌纤维中蛋白含量变化。

Other three alien translocation lines referring to chromosome Lr.14 of L.racemosus were also induced via irradiated pollens.After irradiated by gamma raysof 1KR does,the pollens of T.aestivum-L.racemosus Lr.14 disomic addition lineswere used to pollinate wheat varieties"Yangmai No.5"and"Mianyang No.11".M1plants have pairing between wheat chromosomes and Lr.14 ofL.racemosus at PMCMI stage were self-pollinated,and the M2 seeds used to be Giemsa C-banded andfluorescence in situ hybridized.As the result,three alien translocation lines wereobtained and T12 was observed to have distal translocation chromosomes betweenLr.14S and a wheat chromosome segment(TW-Lr.14S·Lr.14L).T13 wasidentified to contain mostly-alien-translocation chromosome(TLr.14L·Lr.14S-W).T14 was proved to contain a translocation between Lr.14L and 6BS,with approximatebreakpoint at 6BS2.2 region, FL0.22 in the short arm of chromosome T6BL.6BS-Lr.14L.

用普通小麦-大赖草Lr.14二体异附加系经辐射处理过的花粉给扬麦5号和绵阳11号授粉，M1代植株进行PMC MI染色体配对分析和Giemsa C-分带，选出PMCMI小麦和大赖草染色体发生配对的植株进行自交，M2代经RTC M期染色体C-分带和原位杂交，鉴定出3个小麦-大赖草易位系，其中T12为由Lr.14大部分和一个小麦染色体片段组成的易位染色体(TLr.14L·Lr.14S-W)；T13含由Lr.14染色体绝大部分与小麦染色体的一个小片段组成的易位染色体(TLr.14L·Lr.14S-W)；T14易位系的染色体易位发生在小麦6BS2.2区和大赖草Lr.14L之间，易位断点在T6BL·6BS-Lr.14L易位染色体的FL0.22附近。

Circular dichroism spectroscopy measurements also reveal that the ordered structure content of α-helical and β-structure of ovalbumin decrease, and the unfolded random structure is enhanced with increasing pressure; While the existence of dextran sulphate to the native ovalbumin, there are no apparent change on the secondary structure of ovalbumin; It seems same to glycinin.

圆二色性光谱分析表明，经超高压处理后，鸡蛋清蛋白分子中规则的二级结构减少，而部分规则的二级结构和无规卷曲含量增加。加入硫酸右旋糖苷的鸡蛋清蛋白溶液经超高压处理后其二级结构中各部分的含量变化不大：对于大豆豆球蛋白，加入硫酸右旋糖苷后，大豆豆球蛋白分子经超高压处理后其有序结构的减少及无规卷曲的增加都相对减缓。

Methods: The rats were injected with thioacetamide 600mg/kg twice at same time for two days to induce the model of acute hepatic failure rat except the normal group injected with the normal saline hypodermically.

按600mg/kg的剂量经皮下注射硫代乙酰胺1次，24小时后按相同剂量重复注射1次，造成大鼠急性肝衰竭模型，于实验前3天至实验结束分别给予各组大鼠生理盐水，不同剂量丹黄方及促肝细胞生长素，观察造模后48小时内大鼠病死率，并于造模48小时后经腹主动脉采血测定ALT、AST、TBil、TNF-α、IL-6，取肝组织作病检。

The allograft was harvested at 6h posttransplantation. Scrambled ODN group: The donor kidney was stored for 6h in ECs containing 1 u M Liposome/scrambled ODN complexes under hypothermal and hypoxia condition, then the donor kidney was transplanted into a SD recipient, and at 6h posttransplantation the allograft was harvested.

五、试验分四组：(1) Control组假手术组，Wister大鼠麻醉后，开腹后，即将伤口缝合，6h后切取左肾；(2) ECs组供肾经ECs(不含脂质体/ODN复合物)低温缺氧保存6h，移植到受体大鼠6h后切取移植肾；(3)deeoy onN组供肾经含1 pM的deeoy onN脂质体复合物的ECs 低温缺氧保存6h，移植到受体大鼠6h切取移植肾；(4)sc~。

Objective:The purpose of the experiment was to study the carcinogenic and mutagenic effects of petroleum asphalt.

目的：研究石油沥青有无致突变和致癌作用。方法：选用大鼠经口急性毒性试验、Ames试验、小鼠经口微核试验、大鼠气管注入及兔经皮涂抹致癌试验，研究石油氧化及直馏沥青的急性毒性以及致癌和致突变作用。

Thereby the fundamental principle of the single practice faction of Taoist theory for inner elixir is come out. Then, mainly according to Wuliu Xianzong and Dacheng Jieyao, author elaborates the approximate appearance of the single practice faction of Taoist art for inner elixir such as"Constructing the foundation in one hundred days","Plucking the great medicine in seven days","Hibernating in Seven days","Keeping the embryo in ten month","The positive deity leaving the body","Cultivating in three years","Seating in front of a wall in nine years"and so on. At the same time common misunderstandings that cause to some terminology are clarified such as "The Xing before the Ming"and"The Ming before the Xing".

文章通过对内丹学南宗、北宗和中派的代表性丹经的发掘和整理，明确这些丹经中的&先天&、&后天&、&元神&、&元气&、&元精&、&阴阳&、&造化&、&心&等等主要概念的基本含义，从而归纳出清修派内丹学的基本理论，接着，主要以《伍柳仙宗》和《大成捷要》中所阐述的内丹术为主要依据，综合南北宗和中派的代表性丹经，把清修派内丹术中的所谓&炼心&、&百日筑基&、&七日采大药&、&七日大蛰&、&十月养胎&、&出阳神&、&三年乳哺&和&九年面壁&等基本丹法大要较清晰地呈现出来，同时澄清人们由于对一些术语概念认识不清而导致的误解，如所谓&先性后命&和&先命后性&的区别。

Cynanchum Lingtai apricot production in the average weight 65 grams, the brightly-colored fruit, juicy rich, sweet-sour taste, sweet from the nucleolus, when the late Qing Dynasty famous Shaanxi, Gansu provinces, the Qing imperial court Tongzhi tribute for years.

灵台生产的牛心杏平均单果重65克，果实色泽鲜艳，汁多味浓，甜酸适口，离核仁甜，清末时就驰名陕、甘两省，清同治年间曾为朝廷贡品。

Chenopodium album,Solanum nigrum, and Amaranthus retroflexus were very susceptible to the herbicides. Polygonum persicaria and Abutilon theophrasti were relatively less susceptible to the herbicides, and Lycopersicon esculentum was not susceptible to it. The relationship between reduction rates of weed biomass and PPM values of weed leaves 2,4, and 6 days after treatment was established.

供试的6种杂草对该混剂的敏感性存在显著差异：红心藜Chenopodium album、龙葵Solanum nigrum和反枝苋Amaranthus retroflexus对该混剂最敏感，ED90值分别为47.65、71.67和29.17g/hm2；春蓼Polygonum persicaria和苘麻Abutilon theophrasti敏感，ED90值分别为96.91、114.20g/hm2；而番茄不敏感。