作用

Nowadays, as more and more attention are paid to glia, which is considered to play an important role in epileptic pathogenesis,In this study, we chose fluoroacetate, a reversible neuroglia metabolic inhibitor as well as a rodenticide that can induce epileptic seizures, to set up a new epileptic animal model by acting on neuroglia to induce seizures.

目前常用的急性化学致痫模型其致痫机制均是作用于神经元，通过对CNS递质的作用来诱发癫痫。虽然，随着胶质细胞在癫痫的发病机制中的作用日益受到关注，但由于缺乏作用于胶质细胞的癫痫模型，使研究胶质细胞在癫痫发病机制中的作用及其与神经元的关系带来了障碍。

This is a result of weak crustal thermal flow action and strong structure deformation during early stage of orogeny.

论文摘要：新疆阿尔泰海西期造山带主要发育两期区域变质作用，第一期变质作用属于区域低温动力变质作用类型，以形成低绿片岩相矿物组合为特征，变质温度较低，而应力作用较强，是造山作用初期热流活动较弱，构造变形强烈环境下的产物。

In addition, NOS activity decreased with the time prolonged in vitro, when oxyhemoglobin, a scavenger of NO, was applied, the NOS activity kept stable. This result above demonstrated that NO can inhibit NOS activity, and it was the inhibition of NOS activity by NO that may be an important protective mechanism to resist the neurotoxicity by Py.

另外，本实验还发现，在体外实验时，一氧化氮合酶活性可随时间的延长而逐渐下降，当向反应体系中加入氧合血红蛋白去除一氧化氮的作用后，则一氧化氮的抑制作用消失，酶活性保持稳定；以上结果表明一氧化氮对于一氧化氮合酶活性具有抑制作用，而且这种抑制作用，可能是机体对抗拟除虫菊酯毒性作用的一种重要保护机制。

Ecr could promote the gastrointestinal motility, which has some dose-effect relationship. The effect on the gastrointestinal motility of Ecr has no significant difference with the domperidone and prepulsid. The mechanism may be that Ecr could affect the activity of the DVC in the spinal cord, and sequentially the activity of pneumogastric nerve were regulated.

白萝卜提取物对胃肠动力有较为明显的促进作用，这种促动力作用存在着一定的量-效关系；白萝卜提取物促进胃肠道动力的作用与经典的促胃肠动力药物对比没有显著性差异；白萝卜提取物促进胃肠动力的作用机制存在通过对支配胃运动的延髓迷走复合体的激活作用，进而调节迷走神经而实现其对胃运动的调节。

The retortion influence of base isolating building and base fixed building under horizontal earthquake effect is discussed, and the difference between them under the same condition is compared.

本文介绍了减震结构的动力特性，并计算了结构在地震作用下各层的位移、速度、加速度和剪力等地震反应；分析了结构在同时受到两个水平方向地震作用时结构的地震反应，从与抗震结构的对比中可见其优越性；选用了不同场地上的地震波模拟了各类场地上的地震作用，分析比较了不同的场地对建筑物减震效果的差异；分析了橡胶垫水平刚度的变化对动力分析结果所造成的影响，提出了在橡胶垫恢复力曲线中，按线性模型进行简化计算的条件；讨论了隔震垫的设置位置，比较了隔震垫设置在首层柱的底部和设置在其它位置的区别；分析了减震结构在连续经历多次地震时（即在地震后、较大余震作用下）是否仍然能够减震的问题；并对水平地震作用下，减震结构和抗震结构的受扭情况进行了讨论，比较了同等条件下两种结构的区别。

The biocatalyzed characters of the purified cellulases were investigated with the CMC-Na as substrate. The most appropriate catalyzed temprature for cellulase 1 is 60 "C,and 65 for cellulase 2. The two enzymes have the extreme stability at the temperatures no more than 50.The CMC-Na has the protective effect on the cellulase. The pH stability range of cellulase 1 is 4 ~ 8, and 6-9 for cellulase 2. Zn2+, Ca2+, Mg2+, K+, Li+can ativate cellulase 1. K+, Li"1 can ativate cellulase 2. Cellulase 1 can mainly decompose CMC and salicin. Cellulase 2 can decompose not only CMC and salicin, but other substrates feebly.

以羧甲基纤维素为底物时，酶1的最适催化温度为60℃，酶2的最适催化温度为65℃，在50℃以下稳定性较好，底物对酶有较强的保护作用；酶1和酶2的最适pH分别为5.5和5.5～6.0，酶1的pH稳定性范围为4～8，酶2的稳定性范围为6～9；Zn~(2+)，Ca~(2+)，Mg~(2+)，K~+，Li~+对酶1有激活作用，K~+，Li~+对酶2有激活作用；酶1主要对CMC和水杨素有分解作用，对其它底物几乎不分解；酶2除了可以分解CMC和水杨素外，对其它底物也有微弱的分解作用。

Studies also indicated that genistein exsists not only in soybeans but also in many kinds of plants such as vegetables and fruits.As a potential anticancer agent, the actional mechanisms of genistein mainly includes as follows:First, genistein can depress the activity of protein tyrosine kinase and transduction pathways for the phosphorylation of receptors and mitosis signal. So genistein can lead to cells' proliferation depressed. Second, genistein has minimal effects of phytoestrogens. It can be combined with estrogen receptor and improve the synthesis of cellular sex hormone binding glulobin, and improve the activity of UDP-glucuronyl transferase. Through these pathways, it can inhibit the cell activity of breast cancer and prostate cancer.

作为一个很有潜力的抗肿瘤物质，三羟异黄酮的作用机制主要包括：①抑制蛋白酪氨酸激酶活性，可阻抑PTK引起的受体磷酸化和有丝分裂的信号传递，导致癌细胞增殖受抑；②弱雌激素作用：可通过与体内雌激素受体结合，并可增加细胞内性激素结合球蛋白的合成，增加UDP-葡糖醛酸转移酶的活性等途径抑制乳腺癌和前列腺癌细胞活性；③拓扑酶Ⅰ和Ⅱ抑制剂，抑制细胞活性；④上调细胞周期性负性调节因子P21WAF1/CIP1的表达，使之负性调节因子作用增强；⑤可阻止胰岛素样生长因子-Ⅰ、肝细胞生长因子和神经生长因子的作用而抑制肿瘤生长；⑥其他：抗氧化作用、抑制热休克蛋白、诱导细胞凋亡、抑制新生血管生成和抑制多种耐药相关蛋白等。

It is the fluorosilicic ion that exsits in the slurry and plays an important role in flotation, fluorosilicic ion not only reacted with Fe〓 on the surface of aegirine to form ionic compound, but also formed stable Si-F bond in Si-O etching reaction. Only ionic compound was obtained when it was attached to hematite surface according to the theories of coordination chemistry, Compared with SiF〓, Fatty acid ion preferentially acts with Fe〓 on the minerals surface, therefore, SiF〓 Can't obstruct the adsorption of collector on the surface of hematite completly, but can reduce the flotation recovery of aegirine selectively.

运用FTIR、XPS等测试方法仔细研究了氟硅酸盐抑制剂对含铁硅酸盐钠辉石的选择性抑制作用机理，氟硅酸盐在弱酸性条件下对赤铁矿浮选的抑制作用很微弱，而对含铁硅酸盐钠辉石强烈抑制，从而扩大了两者之间的浮选差异；SiF〓是矿浆中起抑制作用的主要成分，SiF〓不仅与钠辉石表面的Fe〓形成离子型配合物，而且还与Si-O键形成稳定的Si-F共价键，而与赤铁矿表面只能形成离子型配合物，根据晶体配位场理论，与SiF〓相比较羧酸根离子将优先与矿物表面Fe〓发生配位作用，因此SiF〓的存在并不能完全阻碍捕收剂在赤铁矿表面的吸附作用，却能够选择性地抑制钠辉石的上浮。

Wenxin capsule can promote endolethial cells releasing CO and synthesing 〓, enhance activity of HO, induce angiectasis through activating guanylic cyclase and adenglate cyclate of intracellar of vessel smooth muscle cell to enhance content of intracellar cGMP and AMP. 3. Wenxin capsule can inhibit releasing of platelet activiting factor 〓 which inhibit platelet aggregation and have antithrombosis function. 4. Wenxin capsule can promote activity of t-PA, reduce activity of PAI-1, strengthen fibrinolytic function, therefore inhibit fibrin disposition. 5. Wenxin capsule can inhibit synthesis of smooth muscle cellular DNA. Its function don't kill it directly but prevent transformation from period Go to peried S. 6. Wenxin capsule is an effective prescription of anti-coronary atherosclerosis atherosis. The results of image pattern analysis tastifies that area of lipid plaque in treating group reduce 54% and 58% in contrast with that in control group. The results of light, electro- microscopy show that structure of endolethial cell and smooth muscle cell in treating group is more integral than that in control group.

其作用机制之一是由于该药具有良好的调脂降脂作用，其不仅能明显降低血清LDL-c及升高HDL-c含量，且能有效阻止TC沉积于血管壁，从而保护内皮细胞结构完整；此外，温心胶囊尚具有明显的抗氧化作用，该药不仅能明显降低血浆LPO含量，且能提高SOD活性，同时其对血红素在细胞内代谢的调节作用也参与了抗氧化过程。2 温心胶囊能明显促进内皮细胞释放CO及合成〓，提高HO活性，通过激活血管平滑肌细胞内鸟苷酸环化酶及腺苷酸环化酶引起细胞内cGMP、AMP浓度增加而引起血管舒张。3 温心胶囊能明显抑制血小板激活因子〓的释放，从而抑制血小板聚集，抗血栓形成。4 温心胶囊能明显提高t-PA活性，降低PAI-1活性，增强纤溶功能，从而抑制纤维蛋白沉积。5 温心胶囊能明显抑制平滑肌细胞DNA合成，其抑制作用不是直接杀伤抑制，而是阻止细胞由Go期向S期转化。6 温心胶囊是抗冠状动脉粥样硬化的有效制剂，图象分析结果证实，该药治疗组脂斑面积比对照组缩小了54％和58％，光电镜结果显示内皮细胞及平滑肌细胞结构较为完整。

The tryptophan residues play important roles in DNA photoreactivation catalyzed by CPD photolyases. We have investigated the action mechanism concerning Trp in DNA photoreactivation, and obtained the results as follows: 1 We proposed a mechanism of photosensitized splitting of CPDs by Trp and Trp-containing peptides. 2 Quantum yields of splitting of the model compounds that a Trp linked covalently a CPD were obtained under 290 nm light in various solvents, these values changing with solvent, range from 0.01 to 0.5. 3 Utilizing pulse radiolysis technique, splitting processes were observed in aqueous solution of the CPDs with hydrated electron and some oxidative species (such as hydroxyl radical, bromic radical and azide radical), and obtained their rate constants. In the case of interaction between CPD and hydrated electron, splitting of the CPD anion, and pyrimidine anion transfer an electron to FAD or Rf, were observed. The process rate was slower one order more than that in photolyase. Minor, but highly mutagenic UV-light-induced lesions are (6-4) photoproducts, which are repaired by (6-4) photolyases. These enzymes, discovered in 1993, are not well characterized and their mechanism is still under investigation.

我们研究它的作用机理，获得以下结果：1）建立了色氨酸及其肽对嘧啶二聚体光敏化裂解的直接修复作用机理模型；2）获得了色氨酸共价键连接于嘧啶二聚体的化合物在多种溶剂中290nm光辐照裂解的量子效率，其值随溶剂而变化，范围在0.01-0.5；3）运用脉冲辐解观察到嘧啶二聚体与水合电子和一些氧化性的自由基作用裂解过程，得到相应速率常数；对二聚体与水合电子作用发生裂解以及向FAD返还电子的过程进行了体外模拟；4）（6-4）光解酶的作用机理中一个关键假定是氧杂环丁烷中间体在接受电子后能自发裂解，恢复二嘧啶的结构。

Objective To investigate the effects of interleukin-1 β converting enzyme gene on the biologic characteristics of ovarian cancer cells.

目的 探讨白细胞介素-1 β转换酶的表达，对卵巢癌细胞生物学特性的影响。

Campylobacter: This illness is the most commonly identified cause of diarrheal illness in the world.

弯曲：这种病是最常见的原因查明腹泻病，在世界上。