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FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th/Ts and Th1/Th2 cells balance in peripheral blood, restrain exorbitant TNF-α、IL-1 produced by PMφ, thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF-αmRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflammation and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue, reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage. Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果:(1)FSN有明显的抗炎作用,可显著抑制AA大鼠足跖肿胀与多关节炎,改善大鼠的全身情况,同时明显减轻病变关节滑膜炎症与增生,防止关节软骨及骨质的破坏,其综合作用优于TWP;(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常,纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱,抑制大鼠PMφ过高的TNF-α、IL-1分泌,而发挥抗炎和免疫调节作用;(3)在病变关节局部,FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达,降低滑膜组织中NF-kB表达,并增加凋亡蛋白酶Caspase-3表达,从而抑制滑膜的炎症与增殖;(4)FSN还可下调滑膜组织中VEGF表达,减少血管新生,由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀;(5)FSN的上述作用皆呈现一定的量效依赖关系,高剂量组作用优于低剂量组。

PPAR γ agonist displayed obvious renoprotective action,the mechanism was complicated, it could improve the metabolism of glucose ang lipid, depress blood preasure, protect small vessels endothelium,improve the system activity of blood clotting and fibronolysis, antiinflammation, otherwise the action was more obvious with the time passed, at the early stage the effective was better,so encourage the patients to take the medicine earily; when the patients with the mediate reanl function failure, Avandia did not display significantly renoprotective action, side reaction had no difference compared to the control group,was not necessary to regulate the dose of Avandia.But because of the sample size was small, we needed a biger sample to confirm the results. We confirmed that Prol2Ala had no difference in control case,diabetic nephropathy group and diabete group,In diabetic group and diabetic nephropathy group, Ala carriers compared to noncarrier all kinds of biochemical indicators were not different,Prol2Ala did not have association with diabete and diabetic nephropathy. But because of the sample size was small, weneeded a biger sample to confirm the results.

PPARγ激动剂对糖尿病肾病具有明显的保护作用,保护作用的机制是多方面的,除了改善糖脂代谢,降低血压外,还具有保护小血管内皮,改善凝血和纤溶系统活性,抗炎症等多方面的作用,且作用随着用药时间的延长而日趋明显,在疾病的早期应用效果更佳,故提倡早期用药;对伴有慢性肾功不全的患者,罗格列酮对肾脏靶器官的保护作用显现的并不明显,但副作用与对照组无明显差异,不用根据肾功情况调整用药,但由于样本量较小,上述结论尚需大样本进行进一步证实;本实验研究得出Prol2Ala变异在健康对照组、糖尿病组及糖尿病肾病组均无显著差异,糖尿病组及糖尿病肾病组临床各生化指标与Prol2Ala变异亦无相关性,Prol2Ala与糖尿病及糖尿病肾病不相关。

The theoretical analysis shows that the wave-activity relation presented a nonconservative form in which the pseudoenergy wave-activity density is composed of disturbance kinetic energy, available potential energy and buoyant energy. The local change of pseudoenergy wave-activity density depends on the combination of shear of zonal basic flow, Coriolis force work and wave-activity source or sink as well as wave-activity flux divergence.

理论分析表明,拟能量波作用方程具有非守恒形式,其中的拟能量波作用密度主要由扰动动能、有效位能和浮力能三部分组成;拟能量波作用密度局地变化除了受拟能量波作用通量散度影响之外,纬向基本气流切变、科氏力作功以及由非绝热加热和水汽相变所构成的波作用源汇项对其也都有贡献。

Bioassay results revealed: compared with alcohol control, extracts at parameter 1, 4, 7 stimulated the absolute germination rate and potential, radicle growth, plumular axis growth, fresh weight, dry weight at different levels; extracts at parameter 2, 3 stimulated the all germination index except radicle growth and axis growth; extracts at parameter 6 stimulated all but radicle growth and fresh weight; extract at parameter 8 stimulated only the germination potential.

生物检测结果显示,与酒精对照相比:萃取参数1、4和7等条件苦楝叶提取物对杉木种子绝对发芽率、绝对发芽势、胚根长、胚轴长、鲜重和干重等发芽指标均表现出不同程度的促进作用,萃取参数2和3等条件苦楝叶提取对除胚根和胚轴外的各发芽指标起促进作用,萃取参数5条件苦楝叶提取物对除鲜重和干重外的各发芽指标起促进作用,萃取参数6条件苦楝叶提取物对除胚根和鲜重外的各发芽指标起促进作用,而萃取参数8条件苦楝叶提取物仅对绝对发芽势起促进作用

For confirmation of this ancient legend and found out the sexual improvement compounds the testosterone and NO in serum of mice were measured,the weight of sexual organs of mices was detected and the sex behaviour of mice was observed.The testosterone and NO concentration in serum of mice as indicator for screening some improving sexual compounds from Chinese chives was builted.1、The preliminary experiment of Chinese chives confirm sexual improvement functionThe sexual improvement function experiments of Chinese chives comparing with herba epimedii,herba cynomorii and radices morindae which were acknowledged as chinese herbals having sexual improvement function were carried out.The result was showed that the Chinese chives was confirmed having sexual improvement function,though its efficacy was less than herba epimedii,herba cynomorii and radices morindae.

为了证实古代医学认为韭菜的壮阳功能,揭示韭菜起温肾壮阳作用的化学物质基础,开发其功能性物质成分,本实验首先应用韭菜酒精初提液对小鼠睾酮、NO含量、性器官、性行为等指标的测定,验证韭菜是否具有改善性功能作用,然后以小鼠睾酮、NO含量等为指标对韭菜中的壮阳物质进行逐步分离和改善性功能作用筛选,以鉴定出几种改善性功能的物质。1、韭菜改善性功能的验证将韭菜与淫羊藿、琐阳、巴戟天三种有温肾补养功能的中草药进行比较,发现韭菜改善性功能作用不如淫羊藿、琐阳、巴戟天壮阳中草药的效果明显,但是韭菜还是具有显著的改善性功能作用的(P<0.001)。

Combined crystallization kinetics analysis obtained via rheometry and morphological observation of crystals growth performed on POM, two different mechanisms of shear-enhanced crystallization for PP/ grafted MWCNTs composites were suggested:(1) at low temperature, strong heterogeneous nucleation plays a dominant role on the. crystallization behavior, which would be saturated at a higher filler content, and the effect of shear-enhanced crystallization was weak;(2) at high temperature, the effect of heterogeneous nucleation was substantially depressed, and the crystallization of the composite was obviously accelerated by pre-shear and the thread-like crystallites were generated earlier than the spherulites.

结合流变测试结果和热台偏光显微镜观察的结晶形貌发展过程,对于PP/G—MWCNTs体系得到了两个不同的剪切影响机理:(1)在低温条件下,强烈的异相成核作用对结晶行为的影响占主导优势,而剪切作用对结晶的影响十分微弱,同时,在填料含量较高是,异相成核作用具有饱和性;(2)在高温条件下,异相成核作用被抑制,复合体系的结晶主要受到预剪切作用的影响,并且纤维状晶体较球晶更易生成。

The inhibition substances in Sorbus pohuashanensisHedl fruit not only restrained the seeds of wheat, cabbage from germinating but also restrained height and root growth. After the seeds of wheat, chinese cabbage had been soaked in the water extraction of pulp, seed and decoated seed for 8h, the seed germination rates were 92% and 84%, 89% and 65%, 94% and 78%, lower than the control, especially the water extract of decoated seed; and the root length and seedlings height were lower than the control, especially the water extract of pulp, and decreased in sequence of soaking time from short to long. So the simplest and effective method to eliminate pulp soluble inhibiting substances is to wash fruits by flowing tap water soon after collection.

在几种浸泡时间中,浸泡8小时的去皮种子浸泡液对白菜、小麦种子发芽率的抑制作用最为明显,其发芽率分别为65%、89%,但随着浸泡时间的延长而降低;浸泡8h的果肉浸泡液对白菜和小麦幼苗高生长和根伸长的抑制作用最为明显,种子和去皮种子浸泡液(8h)的抑制作用对小麦和白菜的抑制作用次之,随着浸泡时间的延长,果肉浸泡液的抑制作用逐渐减弱,因而采收下来的果实及时净种是清除果肉水溶性抑制物质简单有效的方法。

Results ①Five days after abdominal application of Xiaoji power(0.1 g per mouce),the medicine showed a very significant effect in enhancing gastrointestinal propulsive function.② Xiaoji powder not only had relaxing effect on the normal smooth muscle in vitro,but also had a strong spasmolytic effect on acetylcholine,green bariuminduced spasm of intestinal smooth muscle.The experiment was based on 10 μg atropine sulfate as a positive control to carry out control experiments.It showed the graphics of atropine sulfate in spasmolytic role.③Xiaoji powder navel paste therapy played a positive role in adjusting the gastrointestinal electric disorder caused by deficiency of spleen Qi,and could restore it to its normal state.

结果 (1)以0.1 g/只消积散给予小鼠腹部用药5 d,即显示非常显著的增强胃肠推进功能作用;(2)消积散不仅对正常离体平滑肌有舒张作用,同时对由于乙酰胆碱、氯化钡引起的肠平滑肌痉挛也有强的解痉作用,该实验是以硫酸阿托品10 μg作为阳性对照药进行对照实验,显示了硫酸阿托品的解痉作用图形;(3)消积散敷脐对脾虚引起的胃肠电紊乱有明显的调节作用,使脾虚大鼠的胃肠电基本恢复到正常状态。

By studying reservoir rock characteristics, diagenesis and physical property, investigation showed that there were distributary channel, branch channel, mouth bar, distal bar, sand sheet, lakeshore, shallow lake and limestone flat . we concluded that the reservoir of N1~N21 is low porosity and permeability reservoir with the types of primary porosity and secondary intergranular porosity, which is in the early diagenetic stage B into the late diagenetic stage A subperiod. The role of effecting reservoir physical property is deposition, cementation, dissolution and tectonic rupture. After researching of reservoir, we divided it into three categories and division the favorable facies belt and relatively favorable. We think that the favorable facies belt is braided river delta front and partly shallow lake in east of the Fault Ⅶ. favorable reservoir is in the first and the second class.

进一步研究了本区碎屑岩储层的岩石学特征、成岩作用特征、物性特征,研究认为该区储集体类型有分流河道砂体、分支河道砂体、河口坝、远砂坝、席状砂砂体、滨湖砂滩、浅湖砂坝砂体及灰坪;N1层属于低孔、特低渗储层,孔隙类型以原生、次生粒间溶孔为主;分析了影响储层物性的因素主要为沉积作用、胶结作用、溶蚀作用和构造破裂作用;进行了储层评价与有利相带预测,将储层分为三类并划分了有利区带、较有利区带,认为Ⅶ号断层以东的辫状河三角洲前缘亚相和部分浅湖亚相是N1的有利储集相带,储层以Ⅰ、Ⅱ类为主。

Estrogen deficiency can increase the mRNA expression of MMP-1、MMP-3 and IL-1β in OA synovia tissue. Estrogen could inhibit the mRNA expression of MMP-1、 MMP-3 and IL-1β in OA synovia tissue. Progestin could even decrease this expression. Estrogen could slightly increase the mRNA expression of TIMP-1. It is suggested that low dose of estrogen supplement play a protective effect on OA cartilage, and progestin could increase this protective effect.

雌激素缺乏可使OA关节滑膜中MMP-1、MMP-3和IL-1β mRNA表达增加,雌激素对关节滑膜组织中MMP-1、MMP-3和IL-1β mRNA表达有抑制作用,孕激素可增强雌激素的这一抑制作用,雌激素对TIMP-1有轻度升高作用,提示低剂量雌激素对OA关节软骨有一定保护作用,而加用孕激素这一保护作用增强。

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