三乙酰胺

In this thesis, a convenient and efficient synthesis of highly functionalizeddihydropyrido[2,3-d]pyrimidines via a double [5 + 1] annulation strategy startingfrom easily available α-alkenoyl-α-carbamoyl ketene--acetals 1 and cheapreagents (NH4OAc, DMF, and POCl3) has been developed.

本论文探索了一种简便有效的合成高度官能化的二氢吡啶并[2，3-d]嘧啶的方法，此方法由易得的α-乙酰基-α-氨基乙酰基二硫缩烯酮1和便宜的试剂(醋酸铵，二甲基甲酰胺和三氯氧磷)通过两步[5 + 1]加成而实现。

Ophenyl phenol,ophenyl phenol sodium salt tetrahydrate,7ADCA,2ethyl phenyl hydrazine hydrochloride,2,3dihydrofuran,7ethyl3(2hydroxy ethyl)indole,methyl ester of etodolac; 1,8diethyl1,3,4,9tetrahydropyrano[3.4b] indole1acetic acid methyl ester,5chloro2methoxy benzoic acid,4(2aminoethyl)benzene sulfonamide,5cyano phthalide,phthalhydrazide,9thioxanthenone,n[(1,4benzodioxane2yl)carboxyl]piperazine HCL,2chloro4amino6,7dimethoxyquinazoline,2chloro benzimidazole,1(4fluorobenzyl)2chlorobenzimidazole,2methylthio4pyrimidone,5amino4imidazole carboxamide HCL,6chloro2hexanone,11oxo6.11hydrodibenzothiepin,6,11dihydrodibenzooxepin11one,10,11dihydrodibenzocyclohepten5one;dibenzosuberone,dibenzo cyclohepten5one;dibenzosuberenone,3,5dihydroxy benzoic acid,3,5dihydroxy benzyl alcohol,2mercapto benzimidazole,3,4dihydroxy benzaldehyde,3,4dihydroxy benzonitrile,2amino5chloro benzonitrile,2(4chlorophenoxy)ethyl chloride,2(4chloro phenoxy)tert,butane,ditrimethylol propane;DTMP,2,2bis(4hydroxyphenyl)butane; bisphenol B,1,1'bis(4hydroxyphenyl)cyclohexane;bisphenol Z,tetrabromobisphenolS,3,5ditertbutyl salicylic acid,3,4,5trihydroxy benzoic acid stearyl ester,1,2,4trimethoxybenzene.

华业公司产品：邻苯基苯酚，邻苯基苯酚钠盐，7氨基3去乙酰氧基头孢烷酸，邻乙基苯肼盐酸盐，2，3二氢呋喃，7乙基色氨醇，依托度酸甲酯，5氯2甲氧基苯甲酸，4(2氨乙基)苯磺酰胺，5氰基苯酞，双酮酞嗪，9噻吨酮，N〔(1，4苯并二恶烷2基)羰基〕哌嗪盐酸盐，2氯4氨基6，7一二甲氧基喹唑啉，2氯苯并咪唑，1(4氟苄基)2氯苯并咪唑，2甲硫基4嘧啶酮，5氨基咪唑4 甲酰胺盐酸盐，6氯2已酮，11氧6.11二氢苯并〔b.c〕虑平，11氧代6，11二氢二苯并氧杂卓，10，11二氢二苯并环庚烯5酮，二苯并环庚烯5酮，3，5二羟基苯甲酸，3，5二羟基苯甲醇，2巯基苯并咪唑，3，4二羟基苯甲醛，3，4二羟基苯腈，2氨基5氯苯腈，2(4氯苯氧基)1氯乙烷，2(4氯苯氧基)叔丁烷，双丙烷，2，2二(4羟基苯基)丁烷；双酚B，1，1'双(4羟基苯基)环己烷；双酚Z，2[3，5二溴4(2，3二溴丙氧基)]苯砜，3，5二叔丁基水杨酸，3，4，5三羟基苯甲酸十八烷基脂，1，2，4三甲基氧基苯。

Water,Hydrogenated Polyisobutene,Cyclohexasiloxane,Glycerin,Alcohol Denat,Cetearyl Alcohol,PEG-20,Petrolatum,C13-14 Isoparaffin,Zea Mays Oil,Tocopheryl Acetate,Hydroxypropyl Tetrahydropyrantriol,Hydrolyzed Soy Protein,CI 14700/Red 4,Phenoxyethanol,Adenosine,PEG-100 Stearate,Ethylparaben,Triethanolamine,Polyacrylamide,Malus Domestica Stem Cell Culture,CI 19140/Yellow 5,Dimethyl Isosorbide,Dimethicone,Dimethiconol,Limonene,Xanthan Gum,Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate,Linalool,2-Oleamido-1,3-Octadecanediol,Capryloyl Salicylic Acid,Acrylates/C10-30 Alkyl Acrylate Crosspolymer,Passiflora Edulis Seed Oil,Disodium EDTA,Castanea Sativa Seed Extract,Butyrospermum Parkii· Cetyl Alcohol,Butylene Glycol,Octyldodecanol,Cetearyl Glucoside,Methylparaben,Citronellol,Prunus Armeniaca Kernel Oil,Laureth-7,Coumarin,Oryza Sativa Bran Oil,Glyceryl Stearate,Fragrance

水，甘油，氢化聚异丁烯，液体石蜡/矿油，丁二醇，环己硅氧烷，鲸蜡醇，甘油硬脂酸酯，棕榈油，玉米胚芽油，PEG-100硬脂酸酯，白蜂蜡/蜂蜡，肉豆蔻醇肉豆蔻酸酯，石蜡，香精，腺苷，苧烯，山梨醇，CI 14700，CI 19140，稻糠油，杏仁油，EDTA二钠，羟丙基四氢吡喃三醇，苯氧乙醇，聚乙二醇-14M，异十六烷，氢氧化钠，辛基十二醇，季戊四醇四（双-t-丁基羟基氢化肉桂酸）酯，山梨坦三硬脂酸酯，水解大豆蛋白，卡波姆，鸡蛋果籽油，苹果果实提取物，欧洲栗籽提取物，异山梨醇酐二甲醚，聚山梨醇酯-80，辛酰水杨酸，2-油酰胺基-1，3-十八烷二醇，氯苯甘醚，麦芽糖醇，香豆素，黄原胶，微晶蜡，丙烯酰胺/丙烯酰基二甲基牛磺酸钠共聚物，丙二醇，芳樟醇，香茅醇，玉米油，羟苯丙酯，羟苯甲酯

Project Background and Conditions: The company started research new chemical products in 1998. After two years of efforts, a series of pharmaceutical intermediate sulfathiazole leave instructions, including : 3- methyl sulfathiazole leave instructions, 2- sulfathiazole leave instructions ethanoic acid, 2- acetyl sulfathiazole leave instructions, 2-thiofuran amino ethane ,2-thiofuran acetic, 3,4,5- tighter nitrobenzene have been successfully developed. 2-thiofuran amino ethane are the precursors raw materials of series antibiotic analgesic.

二、项目建设背景及条件：1998年公司开始研究开发高新精细化工产品，经过两年的努力，已成功研制出噻吩系列医药中间体，包括：3-甲基噻吩、2-噻吩乙酸、2-乙酰噻吩、2-噻吩乙胺、2-噻吩乙醇、3，4，5-三氯硝基苯等。2-噻吩乙胺系列噻吩产品使用于血小板及血栓有关的心脏血管病及消炎镇痛等如氯吡格雷、兴孢噻吩钠、兴孢西丁、噻吩洛酸等十几种新药的前体原料，是国家政策鼓励发展和有自主知识产权的项目。

hydroxy-2-acetonaphthene was obtained by the hydrolysis of 6-methoxy- 2-acetonaphthene in the presence of HCl (36%) and triethylamine as a catalyst.

摘 要：采用6 甲氧基 2 乙酰萘与浓盐酸在缚酸剂三乙胺存在的条件下进行水解反应制得6 羟基 2 乙酰萘。

In this thesis,the AM1,MNDO,MINDO/3(mainly AM1)and INDO/S-CI semiempirical MO methods were used toinvestigate the excited-state intramolecular protontransfer reactions of salicylic acid derivatives—salicylic acid,methyl salicylate,salicylaldehyde,o-hydroxyaceto-phenone,salicylamide and 3-hydroxy-picolinamide (6 conformers and 2-3 anion species);2-(2'-hydroxy-5' methylphenyl) benzotriazole(4 conformers),2-(2' hydroxyphenyl) benzimidazole (3 conformers and 3anion species),Bis-2,5-(2-benzoxazolyl)hydroquinone(3 conformers),2-(2'-hydroxyphenyl)benzothiazole(2conformers) and 7-azaindole dimer (2 conformers).Theinvestigations were described as follows.Geometry optimization,relative stability andhydrogen bonding energy First,for sylicylic acid derivative molecules,the AM1,MNDO and MINDO/3 methods were used toinvestigate ground-state geometry optimization,energies,relative stabilities and hydrogen-bondingenergies on the five kinds of the molecules(designing 6 conformers and 2-3 anion species).Comparing with experimental data,the optimizedgeometry,the order of stability,the hydrogen-bonding energies and the distances between O-O in O-H..O hydrogen bonds by AM1 method were in agreementwith the experimental data,however,the C-C bondlengths optimized by MNDO and MINDO/3 were longer,C-O and O-H bond lengths were shorter;for C-N bondlengths,the results opitimized by MNDO method werethe same as those by AM1 method,nevertheless the C-Nbond lengths given by MINDO/3 method were muchshorter.For some sylicylic acid derivatives(e.g.methyl salicylate,salicylamide),the order ofstabilities on the conformers given by MNDO andMINDO/3 methods were not in agreement with theexisting conformers deduced by experimental methods,and the hydrogen bonding energies calculated by MNDO.and MINDO/3 methods were smaller.Second,the studyon the other systems found that the optimizedgeometry of the proton-transfered product with INDOmethod could not be obtained,only could theoptimized geometry of reactant be obtained,and thecalculated hydrogen bonding energies were greater.Many results of calculation indicated that the studyon the excited-state intramolecular proton transferreaction system using AM1 method was suitable andreliable.

本论文用AM1、MNDO、MINDO/3（主要是AM1）和INDO/S-CI半经验分子轨道方法对水杨酸衍生物系列——水杨酸、水杨酸甲酯、水杨醛、O-羟基乙酰苯酮、水杨酰胺和3-羟基吡啶酰胺（6种异构体和2-3种阴离子）；2-（2'-羟基-5'-甲基苯基）苯并三〓唑（4种异构体）；2-（2'-羟基苯基）苯并咪唑（3种异构体和3种阴离子）；2，5-二间氮杂氧茚氢醌（3种异构体）；2-（2'-羟基苯基）间〓杂硫茚（2种异构体）和7-〓吲哚二体（2种异构体）的激发态分子内质子转移反应在以下几个方面进行了较系统的理论研究：几何构型优化和相对稳定性及氢键能首先以水杨酸衍生物系列分子为例，用AM1、MNDO和MINDO/3方法考察了5种分子（每种分子设计6种异构体和2-3种阴离子）的基态几何构型优化，能量、相对稳定性和氢键能计算，通过和实验数据进行比较，AM1方法给出的优化几何构型、稳定性次序、氢键能和O—H。。。O氢键的0—0距离与实验数据吻合最好，MNDO和MINDO/3方法优化的C-C键长偏长，C-O键和O-H键长偏短；对于C-N键长，MNDO和AM1优化结果差别不大，而MINDO/3给出了过短的C-N键长，MNDO和MINDO/3方法给出的有些水杨酸衍生物分子（如水杨酸甲酯和水杨酰胺）异构体的稳定性次序和实验上推测的可存在异构体结果不一致，MNDO和MINDO/3方法给出的氢键能偏低，对其他体系的研究发现INDO方法常常不能得到质子转移产物的优化几何构型，只能得到反应物的优化构型，并且估算的氢键能偏高，大量的计算结果表明AM1方法对本论文研究的激发态分子内质子转移反应体系是适宜和可靠的。

Water, Sodium Laureth Sulfate, Cocamidopropyl Betaine, Cocamide MEA, Disodium Cocamphodiacetate, Sodium Lauryl Sulfate, PEG 40 Hydrogenated Castor Oil, Perfume, Sodium Chloride, Propylene Glycol, Quaternium 80, Methylparaben, Polyquaternium 10, Hydroxypropyl Guar Hydroxpropyltrimonium Chloride, Citric Acid, Diazolidinyl Urea, Tetrasodium EDTA, Polyquaternium 7, Propylparaben, Sodium Hydroxide, Panthenol, Persea Gratissima Oil, Penta Sodium Pentetate, Hedera Helix Extract, Bambusa Vulgaris Extract

水，月桂醇聚醚硫酸酯钠，椰油酰胺丙基甜菜碱，椰油酰胺MEA，椰油酰两性基二乙酸二钠，月桂醇硫酸酯钠，PEG 40 氢化篦麻油，香料，氯化钠，丙二醇，季铵盐-80，苯甲酸甲脂，聚季铵盐-10，羟丙基瓜尔胶羟丙基三甲基氯化铵，柠檬酸，重氮烷基咪唑脲，乙二氨四醋酸四钠，聚季铵盐-7，对羟基苯甲酸丙酯，氢氧化钠，泛酰醇，酪梨油，喷替酸五钠，常春藤萃取物，银竹萃取物。

Ingredients: Water,Lauric Acid,Myristic Acid,Stearic Acid,Propylene Glocol,Potassium Hydroxide,Cocamidopropyl Betaine,Starch Hydroxypropyltrimnium Chloride,Sodium Laureth Sulfate,Glycol Distearate,Lavandula Angustifolia Oil,Creatine,Tetrasodium Edta,Perfume,Dmdm Hydantoin.

成分： 去离子水，月桂酸，肉豆蔻酸，硬脂酸，丙二醇，氢氧化钾，椰油酰胺丙基甜菜碱，淀粉羟丙基三甲基氯化铵，月桂醇聚醚硫酸钠，乙二醇双硬脂酸酯，薰衣草精油，肌酸，乙二胺四乙酸四钠，香精，DMDM 乙内酰脲。

These salts can beprepared on treatment of phosphinimines with trifluoroaceticanhydride. After addition-elimination, triflromethylated β-enaminoesters and β-iminoesters were synthesized by thereaction of the above salts with organozinc reagents.

通过膦亚胺和三氟乙酸酐反应制备了N-三氟乙酰基氨基膦盐，该膦盐和锌试剂发生加成-消除反应后，合成了含有三氟甲基的β-烯胺酯和β-亚胺酯。

A novel fluorescent acrylamide monomer, N-(4-Benzooxazol-2-yl-phenyl)- acrylamide, was prepared from o-aminophenol, p-aminobenzoic acid and acryloyl chloride, with polyphosphoric acid as dehydrating agent and triethylamine as deacidification agent.

以邻氨基苯酚、对氨基苯甲酸和丙烯酰氯为原料，以多聚磷酸为脱水剂、三乙胺为脱酸剂，研制了一种新的荧光丙烯酰胺单体N-[4-（苯并噁唑-2-）苯基]丙烯酰胺。

Cynanchum Lingtai apricot production in the average weight 65 grams, the brightly-colored fruit, juicy rich, sweet-sour taste, sweet from the nucleolus, when the late Qing Dynasty famous Shaanxi, Gansu provinces, the Qing imperial court Tongzhi tribute for years.

灵台生产的牛心杏平均单果重65克，果实色泽鲜艳，汁多味浓，甜酸适口，离核仁甜，清末时就驰名陕、甘两省，清同治年间曾为朝廷贡品。

Chenopodium album,Solanum nigrum, and Amaranthus retroflexus were very susceptible to the herbicides. Polygonum persicaria and Abutilon theophrasti were relatively less susceptible to the herbicides, and Lycopersicon esculentum was not susceptible to it. The relationship between reduction rates of weed biomass and PPM values of weed leaves 2,4, and 6 days after treatment was established.

供试的6种杂草对该混剂的敏感性存在显著差异：红心藜Chenopodium album、龙葵Solanum nigrum和反枝苋Amaranthus retroflexus对该混剂最敏感，ED90值分别为47.65、71.67和29.17g/hm2；春蓼Polygonum persicaria和苘麻Abutilon theophrasti敏感，ED90值分别为96.91、114.20g/hm2；而番茄不敏感。