查询词典 toxicologically

The human cytochrome P450 (CYP450) superfamily members metabolize a vast array of clinically, physiologically, and toxicologically important compounds.

人类细胞色素P450(Cytochrome P450，CYP)是代谢许多重要的内源性和外源性化合物及其前致癌物的一类氧化酶。

The povidone iodine disinfection solution in given dosages is toxicologically safe.

聚维酮碘消毒液毒性较低，对皮肤、粘膜刺激小，在使用浓度下毒理学是安全的。

Other important triazine compounds must also be considered in the assessment of risks. For example, the triazine herbicides exemplified by atrazine are structurally and toxicologically similar to melamine and cyanuric acid.

事实上，欧洲食品安全局（虽然使用传统风险评估方法）指出：&在最坏的情况下即污染物含量最高时，儿童每天食用含有大量奶粉的牛奶太妃糖、巧克力和饼干可超过TDI。&

Since amitriptyline inhibited Kv1.1 and Kv7.2/7.3channels only at toxicologically relevant plasma concentrations,our results suggest a role for these channels in the neuroexcitatoryside effects of amitriptyline.

因为阿密曲替林仅在产生毒理学的相关血药浓度制 Kv1.1和 Kv7.2/7.3通道，因此我们的研究表明了这些通道在阿密曲替林的神经兴奋性不良反应中起的作用。

Reactive oxygen species causing DNA oxidative damage comes from two kinds of ways:one is from cellular normal physiological metabolism;the other is from outer environment.Redox-sensitive green fluorescent protein was expressed in Saccharomyces cerevisiae.Recombinant cells were evaluated in monitoring the changes in the redox state of living cells when challenged with toxicologically relevant metal ions NaAsO_2 or Pb(NO_3)_2 by measuring emission intensity at 510 nm with a Hitachi F6500 fluorescence spectrophotometer,roGFP expressed in yeast responded not only to typical membrane-permeant oxidants H_2O_2 and reductants DTT,but also to toxicological metal ion-induced intracellular redox changes in a dose-dependent manner.Moreover,exposure of yeast cells to NaAsO_2 or Pb(NO_3)_2 at concentrations that induced redox changes reported by roGFP caused up to 2～3 fold increases in DNA mutation frequency.This mutagenic effect was largely caused by oxidative stress since blocking the production of hydryl radicals with thiourea significantly reduced the mutation rate as well as delayed the cell death.

本文将对氧化还原状态变化敏感的绿色荧光蛋白roGFP1-R12，在酵母细胞中实现了多拷贝强表达；荧光扫描经强氧化剂H_2O_2和还原剂DTT以及环境中重金属NaAsO_2或Pb(NO_3)_2处理后的酵母细胞悬液，测定510 nm处的荧光发射强度结果显示，表达的绿色荧光蛋白对氧化还原水平敏感，且在510 nm处的荧光强度与一定的重金属浓度呈正相关，即roGFP1-R12在510nm处的荧光发射值随重金属浓度的增高而增强，从而说明重金属对细胞的毒性在一定程度上很可能是通过破坏细胞内的氧化还原平衡发生作用；同时通过该绿色荧光蛋白对胞内氧化还原状态变化的响应情况可以来实时检测环境中的重金属；遗传学的点突变频率及致死率实验数据表明，重金属能导致菌体的点突变频率和致死率升高，且活性氧的清除剂巯基脲能明显降低这种点突变和致死率，说明由重金属引发的这种点突变和致死效应在很大程度上是依赖于重金属对细胞诱导产生的氧化胁迫。

Based on the construction of international financial centre, we have pushed forward the explorations in the integration of cultural industries with financial services.

2010年及整个"十二五"期间，上海文化产业面临更有利的发展时机、更坚实的发展基础和更完善的发展环境。

The koala is an animal with a large bag in its body.

树袋熊用它的身体的一个大的袋子是一只动物。