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The experimental results show that the mean particle size of griseofulvin precipitated by RESS is smaller than 1, 0μm, narrow distribution and 95% fine particles is smaller than 1. 0μm. Increase of the pre-expansion pressure, the extraction temperature, the expansion chamber temperature, the spraying distance, the concentration of cosolvent and decrease of the nozzle diameter resulted in decrease of the particle size under the operating condition studied. Enhancement of the pre-expansion temperature resulted in increase of the particles size. The SEM of GF shows that the shape of original is atactic and a wide size distribution, but the microparticles obtained by RESS is reverse. Similar melting points and XRD patterns were observed for the original material and the precipitates obtained by RESS.

实验结果表明,用含夹带剂的RESS法制备的灰黄霉素微粒的平均直径在1μm左右,且分布均匀,95%微粒在1μm以下,仅用CO〓作为超临界流体制备的微粒与上述方法制备的微粒的平均直径和分布相似,只是产量太低,而用机械法制备的微粒平均直径在3μm左右且分布较宽;不同的过程参数对沉析微粒尺寸有不同的影响,预膨胀压力、膨胀室温度、溶解温度以及夹带剂浓度的提高或增大,均可使沉析微粒的直径变小;预膨胀温度提高,所得微粒的直径变大;喷射距离的增加,沉析微粒的直径变小;喷嘴直径越小,由此制得的微粒的直径就越小;根据实验结果还可知道,通过理论计算的马赫盘处微粒的直径可以较好地估计出膨胀室中收集到的微粒的直径。

1Unequal number of univalents with decreased degree of synapsis and lagging chromosomes occurred in meiosis.The abnormal chromosomal behavior correlated with heterogenicity gave rise to unequal allocation of homogenous chromosomes to daughter cells and resulted in the deletion of functional chromosoms,thus led to the occurence of a certion proportion of aborted pollens.(2)The interaction between genetic imbalance and such environmental factors as temperature,etc.,further drew forth physiological and even structrural imbalance,with abnormal development of pollen mother cells and tapetal cells,and consequently resulted in no or very few production of pollens.The difference in the interaction between environment and genotype reflected on the unstability of pollen abortion in different years.

1在减数分裂中有数目不等的联合程度较差的单价体以及落后染色体出现,这种与异质性相关的染色体行为异常,导致同源染色体向子细胞的不均衡分配,造成具功能染色体的缺失,从而引起毛白杨一定比率的败育花粉的产生;(2)遗传上的不平衡与温度等环境因子相互作用,进一步引发毛白杨生理乃至结构上的不平衡,花粉母细胞和绒毡层细胞发育异常,从而造成不产粉或产粉较少;环境与基因型互作的差异性导致了花粉败育的年度不稳定性。

This persecution resulted in groups of Anabaptists fleeing together, which in turn resulted in the formation of ethnic groups like the Mennonites, the Amish, and the Hutterites.

这些迫害导致了一群再洗礼派教徒逃亡到一起,后来又致使了门诺派,阿们宗派和哈特派等异教徒的组织的形成。

The Vg-negative reaction of the triploid female rainbow trout could not provide full evidence for the impossibility of liver to synthesize Vg. That Vg was not synthesized resulted from insufficient estradiol due to the retardation of ovaries development, the un-differentiation of follicular cells and the lost interaction of germ cell and somatic cells. It could be concluded from yolk genesis that the shortage of female triploid rainbow trout's Vg resulted from the abortive ooecium, but did not result in sterility.

由于三倍体雌性虹鳟卵巢发育受阻,无滤泡细胞分化,生殖细胞与体细胞的互作缺失,不能分泌足量的17β-E2以诱导Vg的合成,因而肝脏的Vg阴性并不能说明肝脏不具备合成Vg的能力,从卵黄发生的角度分析,卵黄蛋白原的缺乏不是导致三倍体虹鳟雌性不育的原因,而是其卵泡败育的结果。

Results; Three cases had extensive perinephric edema.Two of the three resulted from adverse current through renal sinus.The another resulted from rupture of lower section ureter.

结果; 3例广泛性肾周积液水肿,其中2例由肾窦逆流造成,1例由输尿管下段破裂造成,其余无明显肾周水肿。

The role of gall, retroflux of intestinal fluid and foreign-body reaction resulted from suture with silk thread during reconstruction of traumatic bile duct are probably crucial factors resulted in lasted infiltration of macrophage in bile duct wall, which strengthen formation of the benign biliary stricture.

胆汁的作用、肠液返流以及胆管损伤修复采用丝线缝合引起的异物反应可能是导致胆管局部组织MΦ过度沉着的重要因素,从而加剧胆管瘢痕形成。

Restoration of ODC expression in the HL60-ODC cells resulted in rescue of rottlerin-induced apoptosis of HL60 cells. Simultaneously, phosphothreonine-ODC of rottlerin-treated HL60-ODC cells was highly elevated comparing with HL60-pcDNA3 cells. Taken together, we suggested that rottlerin, a PKCd inhibitor, might decrease phosphothreonine-ODC to reduce both protein stability and enzyme activity of ornithine decarbooxylase and finally resulted in cell apoptosis.

为了侦测鸟胺酸去羧化是否能够负调节rottlerin所引发的细胞凋亡,我们将具有鸟胺酸去羧化cDNA载体稳定转染至HL60细胞内,此细胞称为HL60-ODC细胞,另转染载体的细胞称为HL60-pcDNA3细胞;实验发现HL60-ODC细胞中的鸟胺酸去羧化蛋白为HL60-pcDNA3细胞与HL60细胞表现之2.5倍,同时HL60-ODC细胞提升鸟胺酸去羧化蛋白表现,能够减少rottlerin造成之细胞凋亡现象,并且此蛋白在HL60-ODC细胞中酥胺酸磷酸化较HL60-pcDNA3细胞表现高。

The pathogenesis of strabismic diplopia resulted from dysfunction of ocular movement is unknown. Most of the patients can obtain binocular vision by early active treatment. Monocular diplopia is partly resulted from operative complication.

白内障摘除人工晶体植入术后部分患者合并眼肌运动障碍性复视,其发病机制尚不明确,早期经过积极治疗,大部分患者可获得健全的双眼视觉;单眼复视多为手术并发症所致。

Results Two different ligations resulted in different changes in both morphology of hepatic roght lobe and signals on T1WI ,T2WI and DWI. In Group A, hepatic right lobes resulted in coagulation necrosis with no significant morphological change, but distinct hyperintensity on T2WI and DWI appeared. In Group B, after 24h and 72h of ligations, right lobes were atrophied and darkled, the rest lobes became hypertrophied.

结果 两种血流阻断法引起肝右叶形态及T1、T2及DWI信号发生了不同变化:A组肝右叶即发生凝固性坏死,体积大小无明显变化;T2WI及DWI上表现为明显高信号。B组术后24、72h后右叶体积变小,颜色变暗,左叶代偿性变大;T2WI上肝右叶为中等略低信号,T1WI呈略高信号,DWI上信号强度明显降低。

Top of the line supercars and luxury limos experienced very great demand in the preceding years that resulted in record sales to the delight of manufacturers, but has on the other hand resulted in customers owning not so exclusive models.

顶级超级跑车和豪华豪华轿车经历了非常大的需求,前几年,导致销售额破纪录高兴的制造商,但另一方面造成客户拥有专属的模式并非如此。

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