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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗(来源:A44B8787C论文网www.abclunwen.com)功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

Methods Starting from anisole, liarozole was synthesized by Friedel-Crafts acylation, nitration, nucleophilic substitution, reduction and cyclization.

以苯甲醚为起始原料,经傅克酰基化、硝化、取代、还原、环合等7步反应得到目标化合物利阿唑。

But the concentration of Li2CO3 remains nearly consistent and a new component, CH3OLi, is found in SEI. It can be concluded from these results that anisole reacts with the reduction product of EC and DEC, RCO3Li, in the first process of Li+ intercalating into the carbon electrode. The obtained CH3OLi is helpful in building up a more effective and stable SEI of the carbon electrode, reducing the cointercalation of solvent molecular. All these contribute to the improvement of the cycle performance of lithium-ion battery.

根据以上分析结果,提出了苯甲醚对锂离子电池循环性能的影响机理:在Li+嵌入石墨电极的初次过程中,苯甲醚和EC、DEC的还原分解产物RCO3Li发生基团交换反应,生成CH3OLi,该产物能有效提高石墨电极表面SEI的稳定性,减少锂离子嵌入石墨过程中引起的溶剂分子共嵌入,从而改善电池的循环性能。

Kyoto, and the associated Marrakesh Accords, also established the CDM to provide a flexible mechanism for Annexure 1 parties and their businesses to meet their GHG reduction targets and to assist developing countries to achieve sustainable development.

东京议定书及其相关的马拉咯什议定书,还为已建立的清洁发展机制提供了一个灵活的机制,以使附件一及其企业能够达到减少温室气体排放的目标并帮助发展中国家完成可持续发展。

The CDM is likely to become a key tool for businesses from Annexure 1 parties to meet their home-state GHG emission reduction targets, and to create a source of revenue from reducing GHG emissions.

清洁发展机制很可能成为附件一一方企业满足本国温室气体减排目标、根据温室气体减排量创造收入来源的重要工具。

Under the CDM, an Annexure 1 party or a private entity from within or sponsored by an Annexure 1 party may undertake, in cooperation with a developing country, a project that will result in a net reduction of GHG emissions.

在清洁发展机制下,加入或发起附件一的一方或私人实体将与发展中国家合作完成减少温室气体排放的项目。

In view of above condition, this article carries on the smooth noise reduction to the actual gathered annual ring image with the use of computer imagery processing method.

针对以上情况,本文探讨了利用计算机图像处理的几种方法,对实际采集的年轮图像进行直方图修改、平滑滤波、二值化处理等处理,使处理后的图像在应用到WinDENDRO分析系统时,能快速准确的计算出年轮个数、宽度值等参数,为后续树木生长分析提供精确的数据,解决人工操作费时费力和错漏等问题。

For the synthesis of NHC precursors, there are also several routes: condensation of glyoxal, amines and paraformaldehyde; alkylation of imidazole or monosubstituted imidazole with alkyl halide; annulation of ortho esters and 1,2-diamines; ring closure of hydrazines or amides with acetic anhydride; reduction of thiones with Na/K in THF.

关于N-杂环卡宾前体的合成途径主要有:乙二醛、伯胺和多聚甲醛的缩合反应;卤代烷与咪唑及其取代咪唑的烷基化反应;原甲酸酯与1,2-二胺的成环反应;肼或酰胺与酸酐的环化反应;用Na/K对环硫脲化合物的还原反应。

THE FIRST TOTAL SYNTHESIS OF TAXAMAIRIN B Taxamairin B, representive of rare naturally-occuring rearrang-ed 9(10→20)-abeo-8, 11, 13-triene diterpenoids, has been firstsynthesized by a eleven-step route in an overall yield of 8.19%,starting from commercially available catechol and 1,3-cyclohexan-dione. The improved Friedel-Crafts annulation, thermodynamicallycontrolled-geminal pairing methylation, the selective oxidation ofallyl group and the selective reduction of the less-hindrancecarbon-carbon double bond are the key steps.

二。美丽红豆杉素B的全合成研究 1,美丽红豆杉素B的首次全合成以价廉,易得的邻苯二酚和1,3-环己二酮为原料,经过改良的Friedel-Crafts烷基化反应,热力学控制的α,β-不饱和酮结构的α一位双烷基化,烯丙位的选择性氧化,以及选择性还原位阻较小的碳碳双键等十一步反应,以8.19%的总收率首次完成了美丽红豆杉素B的全合成。

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Must have Coordination and negotiation skill, flexible ideas, and be punctilious person.

必须具备较好的协调与谈判能力,头脑灵活,工作认真仔细

Result: 18 patients are all with simple eye.The pigment mole lies in nasal and temple sides of the ball conjunctiva,in which 2 lie in lacrimal caruncle and semilunar plica.

结果:18例患者均为单眼,色素痣大多数位于内外侧睑裂部球结膜面,2例位于泪阜及半月皱襞,经激光治疗后,10例色素痣消失,有5例行再次激光后消失,2例行第三次激光后消失,1例第四次激光后消失。

Buy the home shilly-shally to see when group the person is in when speaking highly of this net inn, absolutely meeting gives up of the apprehension in the heart.

当一个犹豫不决的买家看到一个群的人都在夸赞该网店时,绝对会打消心中的顾虑的。